Transdermal magnesium: a critical review
Review2017 reviewMagnesium salt sprays, flakes and baths
The authors conclude that the promotion of magnesium through the skin is not scientifically supported, compared with the oral route3.
A magnesium cream in 25 volunteers
Clinical trial25 participants, single blind, placebo56 mg of magnesium per day, 2 weeksPilot study
Serum magnesium rose by 8.5% versus 2.6% with placebo, significantly in the non-athlete subgroup only (p = 0.02). Urinary excretion did not change significantly (p = 0.48). The authors call for longer studies4.
Magnesium sulfate: well tolerated
Expert assessmentCIR panel 2018Reported use up to 11% leave-on and 25% rinse-off
No systemic toxicity issue expected after application, no sensitization potential of magnesium salts based on the panel's experience, and a negative skin irritation test at 50% in mice. The panel concludes that magnesium sulfate is safe5.