Judged safe by the CIR panel
Expert assessment2010 CIR panelExtract, flower, flower and seed oil
Not irritating, sensitizing or photosensitizing in animal and human tests, but mild eye irritants. Judged safe in current uses and concentrations3.
A rich composition, little standardization
Review2013 and 2023 reviews
Triterpenes, saponins, flavonoids, carotenoids and polysaccharides dominate the composition of the genus6. The reviews mostly focus on medical uses: their conclusions are not repeated here7.
2% of clinic attendees react to the test
Case series443 consecutive peoplePatch tests
9 people (2.03%) react to calendula and 5 (1.13%) to arnica. The Asteraceae mix is positive in 4 of the 9 who react to calendula: a test with the plant itself remains useful8. Clinic population, not representative of the general public.
A botanical family that sometimes sensitizes
Review2002 reviewAsteraceae (Compositae)
At least 15 species, including calendula and the chamomiles, have been suspected of sensitizing. Epidemiological data only concern arnica and German chamomile; the rest relies on isolated cases9.
People sensitized to Asteraceae are warned
Case seriesPeople sensitized to chamomile and arnica
The authors advise people allergic to this family against topical use of Asteraceae-based products, because of plant allergens and other constituents of the creams10.