Cinnamaldehyde and eugenol among the most reactive fragrance constituents
Clinical trial1,323 participants, 11 European centersFragrance mix at 8% and its 8 constituents
The mix is positive in 89 of the 1,072 participants tested (8.3%). Among the constituents, reactions are most frequent with oakmoss (24), isoeugenol (20), eugenol (13) and cinnamic aldehyde (10). In the series of 48 fragrances tested separately, no clinical relevance is proven7.
Cinnamon among the spices patch tested
Clinical trial55 people suspected of contact allergySpices at 10 and 25% in petrolatum
At 25% only, three participants react to cinnamon. According to the authors, these isolated responses may mark the detection threshold of a true allergy or a marginal irritation8.
A mud bath with cinnamon essential oil in question
Case report74-year-old womanPatch tests 5 years later
Tests are positive to the fragrance mix, to cinnamon essence, to eugenol, to cinnamic alcohol and to cinnamic aldehyde9.
A cinnamon-flavored toothpaste
Case reportCassia cinnamon oilContact allergy
The case shows that a person allergic to cinnamon can be exposed through many sources, cinnamic aldehyde and its derivatives being very widespread10.