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Titanium dioxide is a white inorganic oxide, a UV filter (Annex VI) and the colorant CI 77891 (Annex IV)12. The regulation allows it up to 25% as a filter, including nano under conditions of purity, crystal form and size2. Applications that expose the lungs through inhalation are excluded for the nano form, and fine powders are regulated separately2.
Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database1 and Regulation (EC) 1223/20092, read in its version consolidated on May 1, 2025. Copy the identifiers in one click for your files.
Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.
Titanium dioxide at 5% attenuates UVA beyond 360 nm less than zinc oxide at 5% or avobenzone at 3%. At a comparable sun factor, its products have lower UVA factors. The authors conclude that it replaces neither one for a high level of UVA protection5.
The best organic UVA filter tested (anisotriazine at 10%) reaches a PF-UVA of 11.82, comparable to the forms of titanium dioxide used at 25%. Depending on the filter chosen, creams are more or less effective6.
Variability between laboratories is proportional to the factor: the higher it is, the greater the dispersion. The authors judge it greater than the public and regulators expect7. A product's factor therefore depends on its formula and the test method, not on a single filter.
Most human and animal studies show that nano titanium dioxide does not go beyond the outer layers of the skin and does not reach the systemic circulation, on healthy or damaged skin. The SCCS considers it non-sensitizing, at most weakly irritating, with no evidence of carcinogenicity by the skin route. It presents no risk on skin up to 25%, but the SCCS does not recommend its use in formulations that may expose the lungs (sprays, powders), because lung inflammation is reported in animals4.
All the studies conclude that the overwhelming majority of nanoparticles stays on the surface. Any passage into living skin gives mixed results, because of very different protocols8.
The studies mostly give moderate to high confidence for genotoxicity, oxidative stress and chronic inflammation. The authors conclude that the nanoparticles could induce chronic inflammation and oxidative stress, but that mechanistic evidence for lung carcinogenicity is insufficient, because of the wide variety of particles and protocols9. It is for this route, inhalation, that the regulation sets restrictions.
According to this review, insoluble nanoparticles of titanium dioxide and zinc oxide do not cross human skin, with no safety difference between micro and nano forms10. The authors work for a cosmetics manufacturer.
This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. Titanium dioxide is a UV filter and a colorant: a product's protection factor depends on its whole formula and the measurement method, and no factor is promised here. Several sources are authored by manufacturers, which the source list indicates.
No trial cited compares several concentrations within the same formula. The model UVA study uses 5%5 and one in vitro trial 25%6. The regulation sets 25% as the maximum for a UV filter, standard and nano forms added together2. The factor obtained depends on the formula tested, not on content alone.
Our white label catalog includes 3 formulas with titanium dioxide: the key active in 1 of them, a supporting ingredient in the others. Every category can be customized (formula, fragrance, packaging).
Mineral filter, with zinc oxide, in a mineral sunscreen cream, a tinted fluid and a tinted serum from the catalog.
The choice between mineral and organic filters is made formula by formula. Here is what the sources say, with no promise of a factor.
| Titanium dioxide | Zinc oxide | Organic filters | |
|---|---|---|---|
| Nature | Inorganic oxide1 | Inorganic oxide11 | Organic molecules (avobenzone, octocrylene, homosalate...)12 |
| Annex VI | Entries 27 and 27 bis (nano): 25%2 | Entries 30 and 30a (nano): 25%2 | One entry per filter, with its own limit2 |
| UVA in the laboratory | At 5%, less attenuation beyond 360 nm5 | At 5%, better attenuation than titanium dioxide5 | Photostabilized avobenzone at 3%: superior to titanium dioxide at 5%5 |
| Inhalation and powders | Nano form: no application exposing the lungs; fine powders separately (Annex III, 321)2 | No application exposing the lungs2 | Condition specific to each entry, for example "not to be used in sprays" for tris-biphenyl triazine2 |
| Other use | Colorant CI 77891 (Annex IV, 143)2 | Colorant CI 77947 (Annex IV, 144)2 | No colorant role |
Peer-reviewed studies and official regulatory sources, checked on November 3, 2026.
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