A cream with 10% oil: the nanocream did better
Clinical trialCream with 10% macadamia oil4 weeksSkin analyzer
The nanocream gave better results than the conventional cream on hydration, pore size, melanin and wrinkles. The abstract describes no oil-free group and gives neither sample size nor values: the effect of the oil alone is not isolated3.
A 24-hour patch test
Clinical trial20 participants aged 22 to 59Emu and macadamia oils
The oils stayed on the back for 24 hours under a patch. Reaction scores, on the scale of the Japanese patch test research group, appear in tables with no written conclusion in the abstract4. Raw data, with no statistical analysis announced.
An oleic profile: the reviews' benchmark
Review2018 and 2022 reviewsOleic acid and skin barrier
The reviews link a high content of oleic acid, which is irritating, to a risk for the barrier when skin is already weakened; on unaffected skin, an oleic-rich oil does not necessarily react negatively, and frequency and duration of use matter56. These reviews did not study macadamia oil itself.