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Ceramides are lipids made of a sphingoid base and a fatty acid. With cholesterol and free fatty acids, they form the lipid lamellae of the stratum corneum that limit water evaporation68. In cosmetics, ceramides (CERAMIDE NP, NG, AP) are added to support the barrier, but the effect depends on the complete formula810.
Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database1234, safety according to the CIR expert panel5. Copy the identifiers in one click for your files.
Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.
The SS-10 discomfort score drops by 66% at 2 weeks and by 76% at 4 weeks. Water loss and pH decrease, and hydration increases. The ceramide is not isolated from the other actives7.
Ceramides must be heated and then dissolved before entering the formula. Undissolved ceramides reduce the formula's ability to restore the barrier in the models tested9.
From a single application, hydration increases and water loss and pH improve for 24 h. At 28 days, the effect is clearer than with the hydrophilic control cream, with wrinkles and texture improved. The effect on hydration persists 7 days after stopping10.
A sphinganine-derived ceramide binds to relaxed hair and protects it from chemical weakening. A shampoo that contains it reduces breakage during brushing. Study by a hair care manufacturer, on hair fibers11.
Ceramides structure the lipid lamellae of the stratum corneum and the water barrier. The authors stress that the link between a ceramide deficit and skin disorders is hard to prove, and consider topical supplementation promising8.
Ceramides, cholesterol and free fatty acids form a lipid matrix, the only continuous pathway through the stratum corneum. It governs how substances enter the skin6.
One or two of these lipids applied alone delay barrier recovery; an equimolar mix of ceramides, cholesterol and fatty acids allows it normally. Speed-up of up to a threefold ratio12.
Ceramides provide a water barrier, hydration and pH regulation. They can be supplied directly, through pseudo-ceramides or through actives that stimulate natural synthesis13.
The margin of safety indicates no concern below 1% ceramide 3. It is 149 for a 3% face cream, 168 for a 5% body milk on the back and 4,111 for a 10% lipstick14.
This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. Most trials test a complete cream, not the ceramide alone: the specific effect of the ceramide is therefore not isolated. One review and one hair study were run by manufacturers; this is indicated in the sources.
Our white label catalog includes 11 formulas with ceramides: the key active in 8 of them, a supporting ingredient in the others. Every category can be customized (formula, fragrance, packaging).
Key active in the barrier serum and cream, also present in an extra-rich cleansing gel and masks.
Washing cream with ceramides and hyaluronic acid, baby and kids washing gel.
Leave-in for coily hair, detangling spray, curl refresh spray, conditioner.
Three lipid classes form the stratum corneum barrier6; niacinamide acts on their synthesis. A barrier formula often combines these approaches.
| Ceramides | Cholesterol | Free fatty acids | Niacinamide | |
|---|---|---|---|---|
| Role in the barrier | Major lipid of the stratum corneum lamellae68 | Second main class of the lipid matrix6 | Third main class of the lipid matrix6 | Multiplies ceramide synthesis by 4 to 5.5 in keratinocyte culture15 |
| Applied alone or as a mix | Alone, delays barrier recovery in mice12 | Alone, same finding; the equimolar mix recovers normally12 | Alone, same finding; the equimolar mix recovers normally12 | Stimulates synthesis by the skin itself, with no lipid supply15 |
Peer-reviewed studies and official regulatory sources, checked on November 2, 2026.
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