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Caffeine is an alkaloid of the methylxanthine family, used in cosmetics on the scalp and the eye area. In the lab, it stimulates the growth of cultured human hair follicles45. Clinically, a review of 9 trials (684 people) concludes in its favor, but with a moderate to very low level of evidence3.
Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database1, safety according to the CIR expert panel2. Copy the identifiers in one click for your files.
Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.
All the trials conclude in favor of caffeine on hair shedding or thinning, but the level of evidence is moderate for 3 trials, low for 1 and very low for 5. Many have no randomization, no placebo and no stated concentration. The authors call for better trials on well-defined products3.
Caffeine offsets the slowing of growth caused by testosterone4. It also lengthens the growth phase and stimulates the proliferation of hair matrix cells, with a stronger sensitivity in female follicles5.
Hair density increases and shedding decreases compared with baseline; hair diameter does not change significantly. 71.05% of participants say they are satisfied. Combination of two actives6.
The number of hairs pulled out in the pull test drops by 2.8 on average, against a rise of 0.6 under placebo (p < 0.001). In 30 subjects, the phototrichogram shows more hairs, higher density and more hairs in the growth phase. Combination of two actives: the effect of caffeine alone is not isolated7.
A combination of niacinamide, panthenol, caffeine, piroctone olamine and zinc improved scalp condition and reduced hair shedding. The effect of caffeine on its own is not isolated8.
The review ranks caffeine, with retinoids and vitamin C, among the promising ingredients for wrinkles and pigmentation spots in the periorbital area. It notes the absence of clinical trials specifically on eye creams and the wide variability of the studies10.
Four formulated creams release more than 85% of the caffeine in 24 hours. With 2.5% dimethyl isosorbide and 2.5% ethoxydiglycol, diffusion exceeds that of three commercial creams: the formula influences how the active diffuses11.
The review describes a caffeine that crosses the skin barrier, present at 3% in common commercial topical formulas. It credits it with an action on lipolysis, antioxidant activity and stimulation of skin microcirculation: these are described mechanisms, not demonstrated effects on a finished product9.
The panel judges caffeine safe in the practices and concentrations of use described in its assessment2.
This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. For caffeine, clinical evidence is limited: few controlled trials, combinations of actives, concentrations often not stated, and several studies run or funded by manufacturers (indicated in the sources). We did not retain any controlled trial on dark circles or puffiness.
Commercial topical formulas most often contain 3% caffeine9; the creams tested for diffusion contain 2%11. Clinical trials on the scalp do not always state the concentration, which the review flags as a limit3. The final level is set with the formulator, depending on the format and the target.
Our white label catalog includes 13 formulas with caffeine: the key active in 2 of them, a supporting ingredient in the others. Every category can be customized (formula, fragrance, packaging).
Key active in the eye care product, also found in toners, scrubs and serums.
Key active in the scalp scrub, also found in a shampoo.
Peer-reviewed studies and official regulatory sources, checked on November 2, 2026.
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