Limited clinical evidence in the Cucumis genus
Review2026 reviewCucumis genus (cucumber, melon and related species)In vitro, in vivo and clinical studies
More than 428 bioactive compounds are listed in the genus. The activities described rest on in vitro and in vivo studies and on limited clinical studies; the mechanisms remain poorly understood. The review covers the whole genus, not the cosmetic cucumber extract5.
An effect on melanin seen with leaves and stems
LaboratoryMethanolic extracts of six parts of the plantB16 mouse melanoma cells
Only the leaf and stem extracts slowed melanin production, by reducing tyrosinase expression without blocking the enzyme. Lutein is the active compound identified (IC50 of 170.7 µM). The fruit, the part commonly used in cosmetics, is not among the active extracts4.