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Betaine, or trimethylglycine, is a water-soluble organic osmolyte that skin is able to transport2. Its CosIng function is humectant1. Cosmetic data come mostly from the laboratory: it acts on barrier proteins in human skin culture2. No clinical trial isolates it yet. It is not the same as cocamidopropyl betaine, a surfactant9.
Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database1. Copy the identifiers in one click for your files.
Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.
Skin expresses betaine transporters. When exposed to betaine or taurine, it produces more claudin-1, claudin-4 and occludin, which are tight junction proteins, and tight junction function increases in cultured keratinocytes. The effect disappears when the transporter is blocked2.
Of 89 genes modified by betaine, keratin 2, a differentiation marker, is the most increased. The authors note that betaine is widely used in skincare despite the lack of studies on its own effects3.
In the presence of organic osmolytes, the function of developing tight junctions is preserved after UVB. The effect does not go through cell volume or free radicals. The abstract does not say which osmolyte carries the effect: it applies to the betaine family, not to betaine alone7.
The complex increases aquaporin 3, a water channel of the epidermis, by up to 380% compared with the negative control. The effect is attributed to the combination, not to trimethylglycine alone4.
The shower gel improved skin hydration after one use and over 28 days, with good tolerance. The abstract gives neither the sample size nor the values, and the study does not separate trimethylglycine from aloe vera4.
Betaine can be measured in human hair. The authors show, in principle, that a shampoo can redeposit some on the fiber. They describe preliminary investigations, with no demonstrated effect on hair quality5.
Of four osmolytes, only betaine protects the protein under oxidative stress. It also limits stress caused by cold, but increases it under UVA. A protein model, not hair: effects depend on the conditions6.
The panel concludes that alkyl betaines, which are surfactants, are safe in current uses, provided they are formulated to be non-irritating. This report does not cover betaine alone8.
The panel states that synthesis impurities (DMAPA, amidoamine) are known sensitizers. It judges these surfactants safe when formulated to be non-sensitizing9.
7 of 10 people reacted to at least one product. Of 9 tested afterward, 6 reacted to amidoamine. None reacted to amidoamine-free cocamidopropyl betaine10.
This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. For betaine, the published data are laboratory results or trials on combined products: they do not prove the effect of betaine alone on skin. Two cited studies have an industry affiliation; this is noted in the sources.
Our white label catalog includes 5 formulas with betaine, always as a supporting ingredient. Every category can be customized (formula, fragrance, packaging).
Supporting active in a scalp spray and a shampoo.
In our formulas, it is most often paired with
Panthenol 3Hyaluronic acid 2Urea 2Allantoin 1Aloe vera 1Peer-reviewed studies and official regulatory sources, checked on November 3, 2026.
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