UVA on fibroblasts: less damage in culture
LaboratoryHuman Hs68 fibroblasts, UVA at 8 J/cm²Extract standardized to 26.2% phenols, including 22.2% oleuropein2.5 to 25 µg/mL, 24 h before irradiation
The extract reduced the DNA damage and reactive oxygen species induced by UVA, and preserved cell viability by limiting apoptosis. The secretion of TNF-α and IL-2 induced by UVA decreased in cultured lymphocytes. A laboratory result, not verified in volunteers5.
An unexpected effect: more melanin secreted in culture
LaboratoryPrimary human melanocytes and melanoma cellsStandardized dry extract, 10 to 200 µg/mL
The extract increased extracellular melanin and the dendrite length of melanocytes, with no effect on intracellular melanin. This is a pro-pigmenting effect in culture: it is a reason not to present the extract as evening out skin tone without testing. The authors filed an invention disclosure6.
No controlled cosmetic trial kept
ReviewPubMed search, November 2026
Our searches did not find a controlled trial of an olive leaf extract cream on the skin of volunteers. The skin data we kept are laboratory results56.