Periocular wrinkles: an improvement at 12 weeks
Clinical trial25 participants, 2 centersDouble-blind, randomized, 14 weeks8% emulsion and 40% serum of SCA versus placebo, one side of the face each
Periocular wrinkles on the active side decreased significantly at 12 weeks (p = 0.03) and texture improved more than with placebo. Participants reported no significant difference in the quality of their skin3.
Combination with a snail egg extract
Clinical trial50 women aged 45 to 653 months, versus vehicleSCA + IFC-CAF (egg extract), 30 women in the active group
The active group had a drop in transepidermal water loss and an improvement in roughness, firmness and elasticity. Both groups improved their fine lines and wrinkles. The authors call for larger studies4.
SCA creams + other actives: hydration, firmness, elasticity
Clinical trial120 women aged 40 to 65Open study, no control groupSerum and creams with SCA, ectoin, hyaluronic acid, olive oil and peptides
Hydration, epidermal thickness, firmness and elasticity improved from 45 days. The effect of the secretion alone cannot be isolated, because the formula contains other actives5.
Skin cells in culture: proliferation and migration
LaboratoryHaCaT keratinocytes and dermal fibroblastsSCA, in vitro
The secretion promoted cell proliferation, migration and survival, as well as the expression of adhesion molecules. A cell culture result: it does not predict the effect of a cream8.
Enzymatic activities and extracellular matrix
LaboratoryFibroblasts in cultureSCA
The secretion contained antioxidant activities (SOD and GST), stimulated fibroblast proliferation and extracellular matrix assembly, and regulated metalloproteinases9.