A modified ginseng cream reduces roughness around the eyes
Clinical trialCream with enzyme-modified ginseng extract23 volunteersDouble blind, placebo controlledEye area wrinkles
Significant reduction of the global photodamage score and of roughness (R1, R4, R5) compared with placebo. Participants rated the cream as more moisturizing and softening; no adverse effect was reported. The extract is enzyme-modified: it is not a simple root extract6.
A red ginseng hydrogel and the facial microbiome
Clinical trialHydrogel with a red ginseng formula20 womenFace, split-face comparison
Application decreased C. acnes in all participants and increased S. epidermidis in those who had little. The authors conclude it helps maintain skin balance. Formula containing 1,2-hexanediol, studied on few subjects7.
Oral intake improves wrinkles, with no effect on hydration
Clinical trialRed ginseng + Torilus fructus + Corni fructus, 3 g/day24 weeks82 women over 40Oral route, placebo controlled
Facial wrinkles are significantly improved and type I procollagen expression increases. No change in elasticity, epidermal hydration, redness or pigmentation. A blend of three plants taken orally: it does not transfer to a cream8.
Collagen and barrier markers in culture
LaboratoryWhole micro-granulated red ginseng in a gelHuman fibroblasts and keratinocytesUV, comparison with the aqueous extract
The gel reduced UV-induced MMPs and increased type I collagen in fibroblasts. In keratinocytes, it raised AQP3, HAS2, SPT, CerS3 and filaggrin, more than the aqueous extract. Lab study9.
Ginsenosides act differently on fibroblasts
LaboratoryTissue-cultured ginsengHuman dermal fibroblastsTNF-α stimulation
Rg1 and Re curbed MMP-1 secretion, while Rb1 and Rd increased COL1A1 collagen. Extracts obtained with supercritical CO₂ contained more major ginsenosides. Lab study10.
A main active component that is not clearly identified
Review2024 reviewExtracts, ginsenosides, gintonin, byproducts
The review describes in vitro and in vivo skin studies. It specifies that it is not yet known which component directly contributes to skin health or to preventing skin aging5.