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Hydrolyzed vegetable protein

"Hydrolyzed vegetable protein" is a common name: the INCI in our glossary is a derivative modified with silanetriol groups1. CosIng gives it two functions, hair conditioning and skin conditioning1. Trials on this specific derivative are missing; the safety of the family rests on CIR reviews234.

Beige hydrolyzed vegetable protein powder in macro view on a sage green ceramic surface, raking light

Hydrolyzed vegetable protein at a glance

Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database1, safety according to the CIR expert panel reviews234. The glossary derivative has no CAS or EC number in CosIng.

INCI name
HYDROLYZED VEGETABLE PROTEIN PG-PROPYL SILANETRIOLThis is not the INCI "HYDROLYZED VEGETABLE PROTEIN": the suffix indicates a chemical modification
CosIng description
Hydrolyzed vegetable protein, 2-hydroxy-3-(3-(trihydroxysilyl)propoxy)propyl derivativesSilanetriol groups, Si(OH)₃, are grafted onto the hydrolysate1
Other names
Hydrolyzed vegetable proteinsCommon name; it covers the plain hydrolysate and its derivatives (silanetriol, acyl, quaternary)
CAS number
Not given in CosIng
EC number
Not given in CosIng
Botanical origin
Not specified by the INCI"Vegetable" can mean wheat, soy, pea, rice or oat: ask the supplier for the origin
CosIng functions
Hair conditioning, skin conditioning"Hair conditioning, skin conditioning"1
Appearance
Depends on the supplierRequest the technical data sheet
EU status
Permitted, no dedicated annexNo annex listed in CosIng1
Allergen to declare
NoNot a fragrance allergen. If the source is wheat, see the molecular weight limit5
Safety
Family judged safe under conditions of useCIR panel: plant proteins 2022, wheat 2018, soy 2023234. The 2022 summary does not list this derivative: to be confirmed

What the research says

Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.

Clinical trialReview or consensusLaboratory

HairHair care

A protein hydrolysate modified with an alkyl chain and silicone

Laboratory
Hybrid polymer, supplier studyColored and damaged hairSummary without figures or detailed protocol

The polymer kept color on colored hair and improved shine, manageability, feel, softness and detangling, especially on damaged hair. It is not the silanetriol derivative of this page6.

Silanetriol and panthenol on colored hair

Laboratory
Caucasian hair, oxidative dyeProtein loss, detangling, breakageSilanetriol and panthenol combination, not a protein

The tress colored with this agent lost less protein and detangled more easily than the tress colored alone, with no difference in breaking strength between groups. The silanetriol tested is not a protein derivative7.

Cystine silanetriol on relaxed hair

Laboratory
Afro hair, thioglycolate relaxer creamProtein loss, detangling, tensile strength to breakage

The conditioning agents reduced protein loss and protected the hair. Cystine silanetriol gave one of the best breaking strengths; jojoba oil and a silicone gave the best results on the other measures8.

Safety and allergiesToxicology

19 plant proteins and peptides assessed

Expert assessment
CIR panel 2022Skin and hair conditioning agents

The panel concludes that 18 of the 19 ingredients are safe under the conditions of use described; data are insufficient for a single protein, the sycamore maple one. The summary does not give the full list2.

Hydrolyzed wheat: a peptide size limit

Expert assessment
CIR panel 2018Hydrolyzed wheat protein and wheat gluten

No immediate hypersensitivity reaction in sensitized people and no sensitization when polypeptides do not exceed 30 amino acids. Conclusion: safe if the average molecular weight of the peptides stays at 3,500 Da or less3.

Soy: safe under conditions of use

Expert assessment
CIR panel 2023Soy proteins and peptides

The panel concludes that soy proteins and peptides are safe in the practices of use and concentration described4.

Facial soap with hydrolyzed wheat: a food allergy risk

Epidemiological study
Japan, women aged 20 to 54157 wheat allergy cases, 449 controlsOnline questionnaire

Use of a facial soap containing hydrolyzed wheat protein was associated with a higher risk of wheat allergy (adjusted odds ratio 2.6; 95% confidence interval 1.2 to 5.7). The result concerns one product and one origin, wheat9.

Protein hydrolysates in hair products: contact urticaria

Clinical study
22 hydrolysates tested, 3 groups of participantsSkin tests

Positive reactions appeared in 12 participants, all atopic women, who all reacted to a quaternized collagen hydrolysate of animal origin. The authors conclude that these hydrolysates can cause contact urticaria, especially in atopic people10.

This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. We found no peer-reviewed trial on this specific derivative: the results below concern related materials (silanetriols of other origins, silylated proteins) and say so on each line. No skin result was retained.

Which products can use hydrolyzed vegetable protein?

No formula in our white label catalog features hydrolyzed vegetable protein yet. Our formulation lab can add it to a custom formula or to a catalog formula. Its common uses:

Face

Creams and serums where the INCI acts as a skin conditioner, supporting other actives.

Hair

Conditioners, masks, leave-ins and sprays: conditioning agents, often combined with oils and panthenol.

Hydrolyzed wheat, pea or soy protein?

Four close names, different regulatory regimes. The table compares official texts and CIR opinions, not the efficacy of each material.

Silanetriol derivative (this page)Hydrolyzed wheat proteinHydrolyzed pea proteinHydrolyzed soy protein
INCIHYDROLYZED VEGETABLE PROTEIN PG-PROPYL SILANETRIOL1HYDROLYZED WHEAT PROTEIN5HYDROLYZED PEA PROTEIN11HYDROLYZED SOY PROTEIN
EU regulationNo annex in CosIng1Annex III, entry 307: average peptide molecular weight of 3.5 kDa or less5No annex in CosIng11No entry found in annexes II to V5
CIR opinionNot confirmed: 2022 list not detailed2Safe if peptides are 3,500 Da or less32022 list not detailed2Safe under conditions of use4
Carmel catalog formulas0 formulas0 formulas0 formulas0 formulas

Frequently asked questions about hydrolyzed vegetable protein

What is hydrolyzed vegetable protein?
It is plant protein (wheat, soy, pea, rice) cut into shorter fragments by hydrolysis. In cosmetics, CosIng classifies the glossary INCI as a hair and skin conditioning agent1. The common name covers several INCIs; the one in the Carmel glossary is a silanetriol derivative.
What is the difference between "hydrolyzed vegetable protein" and "PG-propyl silanetriol"?
The INCI HYDROLYZED VEGETABLE PROTEIN PG-PROPYL SILANETRIOL designates a hydrolysate whose proteins carry 2-hydroxy-3-(3-(trihydroxysilyl)propoxy)propyl groups, meaning grafted silanetriol groups1. The plain hydrolysate has no such modification. The two names are not interchangeable on a label: the declaration follows the material actually used. The same modification exists on other proteins, for example HYDROLYZED PEA PROTEIN PG-PROPYL SILANETRIOL.
Is hydrolyzed vegetable protein good for hair?
We found no controlled trial on this specific derivative. Laboratory tests on related materials (silanetriol combined with panthenol, silylated proteins) show less protein loss and better detangling on colored or relaxed hair678. These results come from complete formulas and do not apply as is to your product.
Can it cause an allergy?
The risk depends mostly on the origin and size of the peptides. The CIR panel judges hydrolyzed wheat safe if the average molecular weight of the peptides does not exceed 3,500 Da3, and the European regulation takes up this limit in Annex III5. A Japanese study nevertheless linked a facial soap with hydrolyzed wheat protein to a higher risk of wheat allergy9. Ask for the source plant and the molecular weight distribution.
How do you find the source plant?
The INCI does not give it: "vegetable" can mean wheat, soy, pea or other plants. It appears in the supplier specification and certificate of analysis. It matters for allergies, for your brand specification and for the 3.5 kDa limit if the source is wheat5.
Is silanetriol a silicone?
The INCI name describes silanetriol groups, Si(OH)₃, grafted onto the protein1; it is not a dimethicone-type silicone. If your brand promises "silicone-free", check the definition in your specification before choosing this derivative.
Can you manufacture hair care with hydrolyzed vegetable protein for my brand?
No formula in our catalog features these proteins yet, but our ISO 22716 certified laboratory can add them to a catalog formula or to a custom formula. Free samples are included.

Sources

Peer-reviewed studies and official regulatory sources, checked on November 3, 2026.

  1. European Commission. CosIng, entry HYDROLYZED VEGETABLE PROTEIN PG-PROPYL SILANETRIOL (silanetriol derivatives of hydrolyzed vegetable proteins). ec.europa.eu/growth/tools-databases/cosing
  2. Burnett CL, Boyer IJ, Bergfeld WF, et al.; Expert Panel for Cosmetic Ingredient Safety. Safety Assessment of Plant-Derived Proteins and Peptides as Used in Cosmetics Int J Toxicol. 2022;41(2_suppl):5S-20S. doi:10.1177/10915818221100700
  3. Burnett C, Bergfeld WF, Belsito DV, et al.; Cosmetic Ingredient Review Expert Panel. Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics Int J Toxicol. 2018;37(1_suppl):55S-66S. doi:10.1177/1091581818776013
  4. Burnett CL, Bergfeld WF, Belsito DV, et al.; Expert Panel for Cosmetic Ingredient Safety. Safety Assessment of Soy Proteins and Peptides as Used in Cosmetics Int J Toxicol. 2023;42(2_suppl):102S-113S. doi:10.1177/10915818231174434
  5. European Union. Regulation (EC) No 1223/2009 on cosmetic products, consolidated version of May 1, 2025, annexes II to V. eur-lex.europa.eu
  6. Koyanagi A. Hydrolyzed protein derivatives accompanied with synergy by silylation or siliconizing J Cosmet Sci. 2007;58(4):435-441. PMID 17728944Seiwa Kasei
  7. da Gama RM, França-Stefoni SA, Sá-Dias TC, et al. Protective effect of conditioner agents on hair treated with oxidative hair dye J Cosmet Dermatol. 2018;17(6):1090-1095. doi:10.1111/jocd.12484
  8. Dias TC, Baby AR, Kaneko TM, Velasco MV. Protective effect of conditioning agents on Afro-ethnic hair chemically treated with thioglycolate-based straightening emulsion J Cosmet Dermatol. 2008;7(2):120-126. doi:10.1111/j.1473-2165.2008.00374.x
  9. Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K. Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap Allergy. 2014;69(10):1405-1411. doi:10.1111/all.12481
  10. Niinimäki A, Niinimäki M, Mäkinen-Kiljunen S, Hannuksela M. Contact urticaria from protein hydrolysates in hair conditioners Allergy. 1998;53(11):1078-1082. doi:10.1111/j.1398-9995.1998.tb03818.x
  11. European Commission. CosIng, entry HYDROLYZED PEA PROTEIN (CAS 222400-29-5). ec.europa.eu/growth/tools-databases/cosing
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