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Resources
Hydrolyzed collagen is a mixture of peptides obtained by hydrolysis of animal collagen, used in cosmetics as a humectant and film former1. Molecules above 500 Da do not cross the stratum corneum3: it mostly works on the surface. A 6-month trial showed no benefit from a 2.5% serum4.
Entry from our cosmetic ingredient glossary. Regulatory data from the European Commission's CosIng database12. Hydrolyzed collagen and native collagen have two separate INCI names. Copy the identifiers in one click for your files.
Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.
Fish hydrolysate is the best suited to formulation among those tested (chicken, deer, carp). In a gel, it reduces wrinkles in the periorbital region. Formulation study, with no clinical comparison against other actives6.
The authors recall that the collagen in a cream does not usually penetrate the skin. In micronized form, it reaches the deep epidermis on samples, and the skin is smoother. No clinical trial; the authors are consultants for the company5.
Neither the topical serum, nor oral collagen at 5 g/day, nor their combination changes elasticity, dermis thickness or histological markers compared with placebo. The authors advise against routine use in these women4.
A molecule must weigh less than 500 Da to cross the stratum corneum. This rule of thumb explains why large proteins and peptides mostly work on the surface3.
The authors, affiliated with a collagen manufacturer, describe a low-antigenicity hydrolysate with good hydrating properties on the stratum corneum. The antioxidant effect depends on peptide size: the smaller they are, the stronger it is7.
Hydrolyzed collagen taken by mouth improves hydration in 10 of 15 trials, elasticity in 10 of 13 and wrinkles in 9 of 10. These supplements fall outside cosmetics: these results do not transfer to a cream10.
A case of contact urticaria with systemic symptoms followed the application of a bovine collagen hydrolysate conditioner8. In another series, 12 people with reactive skin reacted to protein hydrolysates, all to a quaternized derivative of hydrolyzed collagen9.
This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. The level of evidence is low: a single controlled trial on topical use, and it is negative. The positive results in the literature mostly concern oral supplements, which are not cosmetics. Studies affiliated with a manufacturer are flagged in the sources.
The studies cited test hydrolyzed collagen at 0.5%, 1.5% and 2.5%. None identifies an effective dose: the only 6-month trial, at 2.5%, is negative4. The final concentration of a formula is set with the formulator, depending on the role you want (humectant, film former, range selling point).
Our white label catalog includes 2 formulas with collagen: the key active in 2 of them, a supporting ingredient in the others. Every category can be customized (formula, fragrance, packaging).
Key active in the post-pregnancy cream, paired with niacinamide, hyaluronic acid and vitamin E.
Peer-reviewed studies and official regulatory sources, checked on November 2, 2026.
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