{"id":62074,"date":"2026-11-03T07:15:33","date_gmt":"2026-11-03T07:15:33","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?page_id=62074"},"modified":"2026-11-10T09:33:34","modified_gmt":"2026-11-10T09:33:34","slug":"peptidos","status":"publish","type":"page","link":"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/peptidos\/","title":{"rendered":"P\u00e9ptidos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"62074\" class=\"elementor elementor-62074 elementor-54476 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-399421d e-flex e-con-full e-con e-parent\" data-id=\"399421d\" data-element_type=\"container\" data-e-type=\"container\" id=\"ing-peptides\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47a682d elementor-widget elementor-widget-html\" 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svg{width:20px;height:20px;flex:none;color:var(--deep-muted)}\n@media (max-width:900px){.ig .c-grid{grid-template-columns:1fr;gap:32px}}\n@media (max-width:560px){.ig form.lead{grid-template-columns:1fr;padding:20px}}\n@media (prefers-reduced-motion:reduce){.ig *,.ig *::details-content,.ig .pop,.ig .scrim,.ig .fab{transition:none!important}}\n.ig .hero h1.h1-long{font-size:clamp(38px,4.6vw,60px);line-height:1.02}\n.ig .pins-list{display:none;list-style:none;margin:0 0 20px;padding:0;order:-1}\n.ig .pins-list li{display:flex;gap:12px;align-items:baseline;margin-bottom:10px;font-size:14px;line-height:1.4;color:var(--ink-2)}\n.ig .pins-list strong{font:600 22px\/1 var(--f-display);color:var(--teal-strong);min-width:72px}\n.ig .scale.dense{display:flex;flex-direction:column;padding-top:0}\n.ig .scale.dense .pins-list{display:block}\n.ig .scale.dense .track .pin{display:none}\n@media (max-width:560px){.ig .scale{display:flex;flex-direction:column;padding-top:0}.ig .pins-list{display:block}.ig .track .pin{display:none}}\n<\/style>\n<div class=\"ig\" data-ing=\"peptides\" lang=\"pt\" data-copy=\"Copiar\" data-copied=\"Copiado\">\n<nav class=\"crumbs wrap\" aria-label=\"Caminho de navega\u00e7\u00e3o\"><ol>\n  <li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/\">In\u00edcio<\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/\">Gloss\u00e1rio de ingredientes<\/a><\/li><li aria-current=\"page\">P\u00e9ptidos<\/li><\/ol><\/nav>\n<header class=\"wrap hero\" id=\"top\">\n  <div class=\"hero-copy\">\n    <h1>P\u00e9ptidos cosm\u00e9ticos<\/h1>\n    <p class=\"brief\">Os p\u00e9ptidos cosm\u00e9ticos s\u00e3o cadeias curtas de amino\u00e1cidos, classificados em p\u00e9ptidos sinalizadores, transportadores, inibidores de neurotransmissores e inibidores de enzimas<a class=\"ref\" href=\"#src-1\">1<\/a>. Os nomes INCI aqui citados n\u00e3o t\u00eam restri\u00e7\u00f5es na UE<a class=\"ref\" href=\"#src-11\">11<\/a>. Os ensaios cut\u00e2neos s\u00e3o curtos e frequentemente realizados pela ind\u00fastria; uma meta-an\u00e1lise de 19 ensaios conclui que o efeito nas rugas \u00e9 modesto, sobretudo devido aos p\u00e9ptidos orais<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p>\n    <div class=\"byline\"><span class=\"avatar\" aria-hidden=\"true\">ME<\/span>\n      <span><strong>Mohamed El Hjouji<\/strong>Fundador e diretor executivo \u00b7 Atualizado <time datetime=\"2026-11-03\">3 de novembro de 2026<\/time> \u00b7 Tempo de leitura 10 min<\/span><\/div>\n    <div class=\"actions\">\n      <a class=\"btn\" href=\"#consultation\">Criar um produto com p\u00e9ptidos <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a>\n      <a class=\"btn-ghost\" href=\"#recherche\">Consultar os estudos<\/a>\n    <\/div>\n  <\/div>\n  <figure class=\"hero-photo\"><img fetchpriority=\"high\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp\" srcset=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-300x224.webp 300w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-441x329.webp 441w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-768x574.webp 768w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-990x740.webp 990w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-1024x765.webp 1024w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp 1400w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp 1400w\" sizes=\"(max-width:900px) 92vw, 46vw\" width=\"1400\" height=\"1046\" alt=\"P\u00e9ptidos cosm\u00e9ticos em p\u00f3 branco, vistos em macro sobre uma superf\u00edcie cer\u00e2mica verde-s\u00e1lvia, com luz rasante\" fetchpriority=\"high\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><\/figure>\n<\/header>\n<div class=\"bar\" id=\"bar\"><div class=\"wrap bar-in\">\n  <nav aria-label=\"Nesta p\u00e1gina\"><ul><li><a href=\"#identite\">Identidade<\/a><\/li><li><a href=\"#recherche\">Investiga\u00e7\u00e3o<\/a><\/li><li><a href=\"#produits\">Produtos<\/a><\/li><li><a href=\"#comparatif\">Compara\u00e7\u00e3o<\/a><\/li><li><a href=\"#faq\">Perguntas<\/a><\/li><li><a href=\"#plus\">Leituras<\/a><\/li><li><a href=\"#sources\">Fontes<\/a><\/li><\/ul><\/nav>\n  <a class=\"btn sm\" href=\"#consultation\" tabindex=\"-1\">Criar o meu produto <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div>\n  <span class=\"bar-prog\" id=\"prog\" aria-hidden=\"true\"><\/span><\/div>\n<section class=\"sec\" id=\"identite\" aria-labelledby=\"h-id\"><div class=\"wrap id-grid\">\n  <div><h2 class=\"h2\" id=\"h-id\">P\u00e9ptidos em resumo<\/h2>\n  <p class=\"lede\">Entrada do nosso <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/\">gloss\u00e1rio de ingredientes cosm\u00e9ticos<\/a>. Dados regulamentares da base CosIng da Comiss\u00e3o Europeia<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a>. \u00abP\u00e9ptidos\u00bb designa uma fam\u00edlia: cada p\u00e9ptido tem o seu pr\u00f3prio nome INCI. Copie o utilizado nas nossas f\u00f3rmulas com um clique para os seus documentos.<\/p><\/div>\n  <dl class=\"spec\"><div><dt>Nome INCI do cat\u00e1logo<\/dt><dd><span class=\"\">PALMITOYL TRIPEPTIDE-38<\/span><button class=\"copy\" type=\"button\" data-copy=\"PALMITOYL TRIPEPTIDE-38\" aria-label=\"Copiar: Nome INCI do cat\u00e1logo\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copiar<\/button><small>Produto da rea\u00e7\u00e3o do \u00e1cido palm\u00edtico com o tripeptide-38<a class=\"ref\" href=\"#src-11\">11<\/a>. Presente no nosso s\u00e9rum e creme com p\u00e9ptidos<\/small><\/dd><\/div><div><dt>Fam\u00edlia<\/dt><dd>P\u00e9ptidos<small>Cadeias curtas de amino\u00e1cidos. O prefixo palmitoyl indica uma liga\u00e7\u00e3o ao \u00e1cido palm\u00edtico<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><\/small><\/dd><\/div><div><dt>Palmitoyl pentapeptide-4<\/dt><dd class=\"num\">214047-00-4 \/ 521091-64-5<small>N\u00fameros CAS; sem n\u00famero CE<a class=\"ref\" href=\"#src-12\">12<\/a><\/small><\/dd><\/div><div><dt>Palmitoyl tripeptide-1<\/dt><dd class=\"num\">147732-56-7<small>N\u00famero CAS<a class=\"ref\" href=\"#src-13\">13<\/a><\/small><\/dd><\/div><div><dt>Copper tripeptide-1<\/dt><dd>Sem CAS na CosIng<small>Complexo de cobre do tripeptide-1<a class=\"ref\" href=\"#src-14\">14<\/a><\/small><\/dd><\/div><div><dt>Acetyl hexapeptide-8<\/dt><dd class=\"num\">616204-22-9<small>N\u00famero CAS; p\u00e9ptido sint\u00e9tico composto por arginina, metionina e \u00e1cido glut\u00e2mico acetilado<a class=\"ref\" href=\"#src-15\">15<\/a><\/small><\/dd><\/div><div><dt>Tetrapeptide-30<\/dt><dd>Sem CAS na CosIng<small>P\u00e9ptido sint\u00e9tico composto por \u00e1cido glut\u00e2mico, lisina e prolina<a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Fun\u00e7\u00e3o CosIng<\/dt><dd>Cuidado da pele<small>O acetyl hexapeptide-8 \u00e9 tamb\u00e9m humectante e o tetrapeptide-30 tamb\u00e9m protege a pele<a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Estatuto na UE<\/dt><dd>Sem restri\u00e7\u00f5es<small>Nenhum destes seis nomes INCI consta dos anexos do Regulamento (CE) 1223\/2009<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Alerg\u00e9nio a declarar<\/dt><dd>N\u00e3o<\/dd><\/div><div><dt>Seguran\u00e7a<\/dt><dd>Varia consoante o p\u00e9ptido<small>Painel CIR: acetyl hexapeptide-8 seguro at\u00e9 0.005%<a class=\"ref\" href=\"#src-10\">10<\/a>. N\u00e3o foi encontrada uma conclus\u00e3o para os outros p\u00e9ptidos citados<\/small><\/dd><\/div><\/dl><\/div><\/section>\n<section class=\"sec research\" id=\"recherche\" aria-labelledby=\"h-r\"><div class=\"wrap\">\n  <div class=\"r-head\"><div><h2 class=\"h2\" id=\"h-r\">O que diz a investiga\u00e7\u00e3o<\/h2>\n  <p class=\"lede\">Cada resultado apresenta o protocolo e o n\u00edvel de evid\u00eancia. Quanto maior for o n\u00edvel, mais aplic\u00e1vel ser\u00e1 o resultado a uma f\u00f3rmula acabada.<\/p><\/div><\/div>\n  <div class=\"r-tools\"><div class=\"seg\" role=\"group\" aria-label=\"Filtrar por \u00e1rea\" id=\"rfilter\"><button type=\"button\" aria-pressed=\"true\" data-d=\"all\">Todos <span>9<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"visage\">Rosto <span>5<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"derm\">Revis\u00f5es <span>4<\/span><\/button><\/div><div class=\"legend\" aria-label=\"N\u00edveis de evid\u00eancia\"><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensaio cl\u00ednico<\/span><span class=\"lvl\"><i class=\"dot r\"><\/i>Revis\u00e3o ou consenso<\/span><span class=\"lvl\"><i class=\"dot v\"><\/i>Laborat\u00f3rio<\/span><\/div><\/div>\n  <div class=\"domain\" data-d=\"visage\"><h3>Pele do rosto<span>Cuidados da pele<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Palmitoyl pentapeptide-4: menos rugas e linhas finas em 12 semanas<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensaio cl\u00ednico<\/span><\/div><div class=\"meta\"><span>3 ppm (0.0003%)<\/span><span>12 semanas<\/span><span>93 mulheres entre os 35 e os 55 anos<\/span><span>Duplamente cego, compara\u00e7\u00e3o entre metades do rosto<\/span><\/div><p>Melhoria significativa das rugas e linhas finas face ao placebo, segundo a an\u00e1lise instrumental de imagens e a avalia\u00e7\u00e3o de especialistas. O p\u00e9ptido \u00e9 bem tolerado. Ensaio realizado por um fabricante<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Acetyl hexapeptide-8: rugas do contorno dos olhos em 4 semanas<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensaio cl\u00ednico<\/span><\/div><div class=\"meta\"><span>2 aplica\u00e7\u00f5es por dia<\/span><span>4 semanas<\/span><span>60 volunt\u00e1rios chineses<\/span><span>Aleatorizado, 3 para 1 face ao placebo<\/span><\/div><p>Efic\u00e1cia antirrugas global de 48.9% no grupo do p\u00e9ptido, face a 0% com placebo. A rugosidade medida em r\u00e9plicas de silicone diminui com o p\u00e9ptido, mas n\u00e3o com o placebo<a class=\"ref\" href=\"#src-4\">4<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Tetrapeptide-30: manchas pigmentares menos vis\u00edveis, em combina\u00e7\u00e3o<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensaio cl\u00ednico<\/span><\/div><div class=\"meta\"><span>P\u00e9ptido + derivado de vitamina C<\/span><span>6 a 8 semanas<\/span><span>39, 19 e 27 volunt\u00e1rios<\/span><span>Duplamente cego face ao ve\u00edculo<\/span><\/div><p>As manchas do rosto atenuam-se ap\u00f3s 6 semanas com a combina\u00e7\u00e3o, mais do que com o p\u00e9ptido ou o derivado de vitamina C isolados. Em 27 mulheres japonesas, a combina\u00e7\u00e3o reduz a pigmenta\u00e7\u00e3o em 26% e 18% segundo a pontua\u00e7\u00e3o SCINEXA. Em laborat\u00f3rio, o p\u00e9ptido limita a express\u00e3o de genes da pigmenta\u00e7\u00e3o ap\u00f3s exposi\u00e7\u00e3o a UVB<a class=\"ref\" href=\"#src-5\">5<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Palmitoyl tripeptide-38: um s\u00e9rum antioxidante, pele mais uniforme<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensaio cl\u00ednico<\/span><\/div><div class=\"meta\"><span>5 ppm (0.0005%) com 15% de vitamina C e acetato de tocoferilo<\/span><span>56 dias, uma vez por dia<\/span><span>Aberto, sem placebo<\/span><span>Mulheres com 40 anos ou mais<\/span><\/div><p>A rugosidade diminui 8 a 9%, a vermelhid\u00e3o reduz-se em 9% e a uniformidade do tom da pele aumenta 8%. O efeito pr\u00f3prio do p\u00e9ptido n\u00e3o \u00e9 separado do efeito dos antioxidantes do s\u00e9rum. Os autores s\u00e3o consultores da marca do s\u00e9rum<a class=\"ref\" href=\"#src-6\">6<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Copper tripeptide-1: evid\u00eancia sobretudo narrativa<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revis\u00e3o<\/span><\/div><div class=\"meta\"><span>Revis\u00e3o narrativa de 2015<\/span><\/div><p>O trip\u00e9ptido GHK forma um complexo com o cobre. Em cosm\u00e9tica, a revis\u00e3o refere maior elasticidade, densidade e firmeza da pele, e menos linhas finas. N\u00e3o detalha aqui nenhum ensaio e os autores est\u00e3o associados a uma empresa de p\u00e9ptidos<a class=\"ref\" href=\"#src-7\">7<\/a>.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"derm\"><h3>Revis\u00f5es, penetra\u00e7\u00e3o e seguran\u00e7a<span>Dermatologia<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Meta-an\u00e1lise: um efeito modesto nas rugas, sobretudo com p\u00e9ptidos orais<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revis\u00e3o<\/span><\/div><div class=\"meta\"><span>19 ensaios aleatorizados<\/span><span>1 341 participantes<\/span><span>P\u00e9ptidos orais e t\u00f3picos<\/span><span>Revis\u00e3o de 2026<\/span><\/div><p>Os p\u00e9ptidos, sobretudo por via oral, melhoram a hidrata\u00e7\u00e3o e a luminosidade. O efeito combinado nas rugas \u00e9 modesto (diferen\u00e7a m\u00e9dia de 0.27) e deve-se sobretudo aos polip\u00e9ptidos orais. Os efeitos na elasticidade e na densidade s\u00e3o inconsistentes. A toler\u00e2ncia \u00e9 boa, com poucos efeitos indesej\u00e1veis<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Quatro fam\u00edlias segundo o modo de a\u00e7\u00e3o<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revis\u00e3o<\/span><\/div><div class=\"meta\"><span>Revis\u00e3o de 2009<\/span><\/div><p>P\u00e9ptidos sinalizadores, inibidores de enzimas, inibidores de neurotransmissores e transportadores: esta \u00e9 a classifica\u00e7\u00e3o de refer\u00eancia. A revis\u00e3o inclui apenas estudos controlados, ex vivo ou in vivo, sobre p\u00e9ptidos ou prote\u00ednas aplicados na pele contra os sinais de envelhecimento<a class=\"ref\" href=\"#src-1\">1<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Penetra\u00e7\u00e3o: a maior parte permanece na camada c\u00f3rnea<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laborat\u00f3rio<\/span><\/div><div class=\"meta\"><span>Acetyl hexapeptide-8 a 10%<\/span><span>Pele humana e de cobaia, in vitro<\/span><span>24 horas<\/span><\/div><p>A maior parte do p\u00e9ptido \u00e9 removida pela lavagem. Na pele humana, 0.22% da dose encontra-se na camada c\u00f3rnea, 0.01% na epiderme e n\u00e3o \u00e9 detetado p\u00e9ptido na derme<a class=\"ref\" href=\"#src-8\">8<\/a>. Para o palmitoyl tripeptide-1 e outro lipop\u00e9ptido, avaliados em 3 volunt\u00e1rios, os p\u00e9ptidos encontram-se \u00e0 superf\u00edcie das c\u00e9lulas da camada c\u00f3rnea, e n\u00e3o no seu interior. Estudo realizado por uma empresa de cosm\u00e9ticos<a class=\"ref\" href=\"#src-9\">9<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Seguran\u00e7a: um limite de 0.005% para o acetyl hexapeptide-8<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Parecer de especialistas<\/span><\/div><div class=\"meta\"><span>Painel CIR de 2025<\/span><\/div><p>O painel considera o ingrediente seguro nas utiliza\u00e7\u00f5es atuais at\u00e9 0.005%. Acima deste valor, os dados s\u00e3o considerados insuficientes para uma conclus\u00e3o<a class=\"ref\" href=\"#src-10\">10<\/a>.<\/p><\/article><\/div><\/div>\n  <p class=\"frame\">Esta ficha resume a literatura publicada sobre uma fam\u00edlia de ingredientes cosm\u00e9ticos. N\u00e3o descreve o efeito de um produto acabado, que depende da sua f\u00f3rmula, nem substitui aconselhamento m\u00e9dico. Os p\u00e9ptidos diferem muito entre si: cada ensaio incide sobre um \u00fanico p\u00e9ptido, por vezes combinado com outros ativos. A maioria dos ensaios citados foi realizada ou financiada por fabricantes, conforme indicado nas fontes. N\u00e3o \u00e9 citado nenhum estudo sobre o cabelo.<\/p><\/div><\/section>\n\n<section class=\"sec products\" id=\"produits\" aria-labelledby=\"h-p\"><div class=\"wrap\">\n  <div class=\"p-head\"><div><h2 class=\"h2\" id=\"h-p\">Que produtos cont\u00eam p\u00e9ptidos?<\/h2>\n  <p class=\"lede\">O nosso <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/\">cat\u00e1logo de marca branca<\/a> inclui 6 f\u00f3rmulas com p\u00e9ptidos: \u00e9 o ativo principal em 4 delas e um ingrediente complementar nas restantes. Todas as categorias podem ser personalizadas (f\u00f3rmula, fragr\u00e2ncia, embalagem).<\/p><\/div>\n  <div class=\"seg p-tabs\" role=\"tablist\" aria-label=\"\u00c1rea\" id=\"ptabs\"><button type=\"button\" role=\"tab\" aria-selected=\"true\" aria-controls=\"pc-visage\" data-p=\"visage\">Rosto <span>4<\/span><\/button><button type=\"button\" role=\"tab\" aria-selected=\"false\" aria-controls=\"pc-cheveux\" data-p=\"cheveux\">Cabelo <span>2<\/span><\/button><\/div><\/div>\n  <div class=\"p-cols\" style=\"--pc:2\"><div class=\"p-col on\" id=\"pc-visage\" role=\"tabpanel\"><h3><span class=\"count num\">4<\/span>Rosto<\/h3><p>Ativo principal do s\u00e9rum e creme antienvelhecimento, ativo complementar nos cremes com ceramidas e centelha-asi\u00e1tica.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/cremes-rosto-marca-branca\/\"><span>Cremes de rosto<\/span><span class=\"n\">3<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/seruns-rosto-marca-branca\/\"><span>S\u00e9runs de rosto<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/seruns-rosto-marca-branca\/serum-peptidos-marca-branca\/\"><span>S\u00e9rum de p\u00e9ptidos<small>Ativo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/cremes-rosto-marca-branca\/creme-antienvelhecimento-peptidos-marca-branca\/\"><span>Creme antienvelhecimento com p\u00e9ptidos<small>Ativo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><div class=\"p-col\" id=\"pc-cheveux\" role=\"tabpanel\"><h3><span class=\"count num\">2<\/span>Cabelo<\/h3><p>Combinados com ceramidas no cuidado sem enxaguamento para cabelo encaracolado e com queratina hidrolisada no s\u00e9rum capilar.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/leave-in-cremes-pentear-marca-branca\/\"><span>Cremes sem enxaguamento e de pentear<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/seruns-sprays-capilares-marca-branca\/\"><span>S\u00e9runs e sprays capilares<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/leave-in-cremes-pentear-marca-branca\/spray-reativador-caracois-leave-in-marca-branca\/\"><span>Spray reativador de carac\u00f3is leave-in<small>Ativo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><a href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/seruns-sprays-capilares-marca-branca\/serum-queratina-peptidos-marca-branca\/\"><span>S\u00e9rum de queratina e p\u00e9ptidos<small>Ativo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><\/div>\n  <div class=\"pairs\"><p>Nas nossas f\u00f3rmulas, este ingrediente \u00e9 mais frequentemente combinado com<\/p><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/manteiga-de-karite\/\">Manteiga de karit\u00e9 <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/oleo-de-amendoas-doces\/\">\u00d3leo de am\u00eandoas doces <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/oleo-de-coco\/\">\u00d3leo de coco <span class=\"num\">3<\/span><\/a><\/div>\n  <\/div><\/section>\n<section class=\"sec\" id=\"comparatif\" aria-labelledby=\"h-cmp\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-cmp\">Pentapeptide-4, p\u00e9ptido de cobre, hexapeptide-8 ou tetrapeptide-30?<\/h2><p class=\"lede\">Quatro dos p\u00e9ptidos mais citados, um por modo de a\u00e7\u00e3o. N\u00e3o se excluem e s\u00e3o frequentemente combinados na mesma f\u00f3rmula.<\/p>\n  <div class=\"seg c-pick\" role=\"group\" aria-label=\"Comparar com\" id=\"cpick\"><button type=\"button\" aria-pressed=\"true\" data-c=\"3\">P\u00e9ptido de cobre<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"4\">Hexapeptide-8<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"5\">Tetrapeptide-30<\/button><\/div>\n  <div class=\"tbl-wrap\"><table class=\"cmp\" id=\"cmp\" data-c=\"3\"><colgroup><col><col class=\"me\"><col><col><col><\/colgroup>\n  <thead><tr><td><\/td><th scope=\"col\">Palmitoyl pentapeptide-4<\/th><th scope=\"col\">Copper tripeptide-1<\/th><th scope=\"col\">Acetyl hexapeptide-8<\/th><th scope=\"col\">Tetrapeptide-30<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Modo de a\u00e7\u00e3o descrito<\/th><td>Sinaliza\u00e7\u00e3o: concebido para estimular a produ\u00e7\u00e3o de colag\u00e9nio<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Transporte: complexo do trip\u00e9ptido GHK com cobre<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Neurotransmissores: interfer\u00eancia presumida na sinaliza\u00e7\u00e3o<a class=\"ref\" href=\"#src-8\">8<\/a><\/td><td>Pigmenta\u00e7\u00e3o: limita a express\u00e3o de genes da pigmenta\u00e7\u00e3o em laborat\u00f3rio<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Objetivo<\/th><td>Rugas e linhas finas<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Elasticidade, firmeza<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Rugas do contorno dos olhos<a class=\"ref\" href=\"#src-4\">4<\/a><\/td><td>Manchas pigmentares<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Evid\u00eancia citada<\/th><td>Ensaio de 12 semanas, 93 mulheres, 3 ppm<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Revis\u00e3o narrativa, sem ensaio detalhado<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Ensaio de 4 semanas, 60 volunt\u00e1rios<a class=\"ref\" href=\"#src-4\">4<\/a><\/td><td>Quatro estudos face ao ve\u00edculo<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Regulamenta\u00e7\u00e3o da UE<\/th><td>Sem restri\u00e7\u00f5es<a class=\"ref\" href=\"#src-12\">12<\/a><\/td><td>Sem restri\u00e7\u00f5es<a class=\"ref\" href=\"#src-14\">14<\/a><\/td><td>Sem restri\u00e7\u00f5es<a class=\"ref\" href=\"#src-15\">15<\/a><\/td><td>Sem restri\u00e7\u00f5es<a class=\"ref\" href=\"#src-16\">16<\/a><\/td><\/tr><tr><th scope=\"row\">Aspeto a considerar<\/th><td>Apenas um ensaio citado, realizado por um fabricante<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Autores associados a uma empresa de p\u00e9ptidos<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>CIR: seguro at\u00e9 0.005%<a class=\"ref\" href=\"#src-10\">10<\/a><\/td><td>Resultados obtidos em combina\u00e7\u00e3o com um derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/section>\n<section class=\"sec\" id=\"faq\" aria-labelledby=\"h-faq\"><div class=\"wrap faq-grid\">\n  <h2 class=\"h2\" id=\"h-faq\">Perguntas frequentes sobre p\u00e9ptidos<\/h2><div class=\"faq\"><details open><summary>O que s\u00e3o p\u00e9ptidos em cosm\u00e9tica?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">S\u00e3o cadeias curtas de amino\u00e1cidos, as unidades que constituem as prote\u00ednas. S\u00e3o classificados segundo o seu modo de a\u00e7\u00e3o presumido: p\u00e9ptidos sinalizadores, transportadores, inibidores de neurotransmissores e inibidores de enzimas<a class=\"ref\" href=\"#src-1\">1<\/a>. No r\u00f3tulo, cada p\u00e9ptido tem o seu pr\u00f3prio nome INCI, por exemplo PALMITOYL TRIPEPTIDE-38 ou ACETYL HEXAPEPTIDE-8.<\/div><\/details><details><summary>Quais s\u00e3o os benef\u00edcios dos p\u00e9ptidos para a pele?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Os ensaios citados incidem sobre rugas e linhas finas menos vis\u00edveis<a class=\"ref\" href=\"#src-3\">3<\/a><a class=\"ref\" href=\"#src-4\">4<\/a>, manchas pigmentares mais discretas em combina\u00e7\u00e3o com um derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a> e pele mais uniforme<a class=\"ref\" href=\"#src-6\">6<\/a>. O n\u00edvel de evid\u00eancia continua modesto: uma meta-an\u00e1lise de 19 ensaios conclui que o efeito nas rugas \u00e9 modesto, sobretudo devido aos p\u00e9ptidos orais<a class=\"ref\" href=\"#src-2\">2<\/a>. Os resultados dependem do p\u00e9ptido, da f\u00f3rmula e da dura\u00e7\u00e3o.<\/div><\/details><details><summary>Que p\u00e9ptido escolher: pentapeptide-4, p\u00e9ptido de cobre ou hexapeptide-8?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Depende da promessa da gama. O palmitoyl pentapeptide-4 \u00e9 testado nas rugas e linhas finas<a class=\"ref\" href=\"#src-3\">3<\/a>, o acetyl hexapeptide-8 nas rugas do contorno dos olhos<a class=\"ref\" href=\"#src-4\">4<\/a>, o tetrapeptide-30 nas manchas pigmentares<a class=\"ref\" href=\"#src-5\">5<\/a> e o p\u00e9ptido de cobre na firmeza, sobretudo numa revis\u00e3o narrativa<a class=\"ref\" href=\"#src-7\">7<\/a>. A escolha \u00e9 feita com o formulador, em fun\u00e7\u00e3o do objetivo e do or\u00e7amento para o ativo.<\/div><\/details><details><summary>Que percentagem de p\u00e9ptidos deve conter um creme ou s\u00e9rum?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Os p\u00e9ptidos s\u00e3o utilizados em doses muito baixas: 3 ppm (0.0003%) de palmitoyl pentapeptide-4<a class=\"ref\" href=\"#src-3\">3<\/a> e 5 ppm (0.0005%) de palmitoyl tripeptide-38<a class=\"ref\" href=\"#src-6\">6<\/a> nos ensaios citados. O painel CIR estabelece 0.005% como limite considerado seguro para o acetyl hexapeptide-8<a class=\"ref\" href=\"#src-10\">10<\/a>. Um \u00abelevado teor de p\u00e9ptidos\u00bb n\u00e3o garante, por isso, a efic\u00e1cia.<\/div><\/details><details><summary>Os p\u00e9ptidos penetram na pele?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Muito pouco. No caso do acetyl hexapeptide-8, 0.22% da dose atinge a camada c\u00f3rnea da pele humana e n\u00e3o \u00e9 detetado p\u00e9ptido na derme<a class=\"ref\" href=\"#src-8\">8<\/a>. Os lipop\u00e9ptidos s\u00e3o detetados \u00e0 superf\u00edcie das c\u00e9lulas da camada c\u00f3rnea, e n\u00e3o no seu interior<a class=\"ref\" href=\"#src-9\">9<\/a>. \u00c9 uma limita\u00e7\u00e3o a conhecer antes de prometer um efeito em profundidade.<\/div><\/details><details><summary>Com que ingredientes combinar os p\u00e9ptidos?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Nas nossas f\u00f3rmulas, s\u00e3o mais frequentemente combinados com manteiga de karit\u00e9, \u00f3leos de coco, am\u00eandoas doces e arg\u00e3o, e niacinamida. Nos ensaios citados, o tetrapeptide-30 foi testado com um derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a> e o palmitoyl tripeptide-38 com vitamina C e vitamina E<a class=\"ref\" href=\"#src-6\">6<\/a>. A compatibilidade da f\u00f3rmula final \u00e9 verificada por testes de estabilidade em laborat\u00f3rio.<\/div><\/details><details><summary>Os p\u00e9ptidos apresentam riscos?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Na meta-an\u00e1lise de 19 ensaios, a toler\u00e2ncia \u00e9 boa, com poucos efeitos indesej\u00e1veis<a class=\"ref\" href=\"#src-2\">2<\/a>. O painel CIR considera o acetyl hexapeptide-8 seguro at\u00e9 0.005%<a class=\"ref\" href=\"#src-10\">10<\/a>; n\u00e3o foi encontrada uma conclus\u00e3o equivalente para os outros p\u00e9ptidos aqui citados, que n\u00e3o t\u00eam restri\u00e7\u00f5es na UE<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a>. Continua a ser aconselh\u00e1vel um teste de toler\u00e2ncia da f\u00f3rmula final.<\/div><\/details><details><summary>Podem fabricar um s\u00e9rum com p\u00e9ptidos para a minha marca?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Sim. O nosso laborat\u00f3rio certificado ISO 22716 disponibiliza 6 f\u00f3rmulas com p\u00e9ptidos (s\u00e9rum, cremes, cuidados capilares) personaliz\u00e1veis, ou uma f\u00f3rmula \u00e0 medida. A escolha e a dosagem dos p\u00e9ptidos s\u00e3o definidas com os nossos formuladores. As amostras s\u00e3o gratuitas.<\/div><\/details><\/div><\/div><\/section>\n<section class=\"sec\" id=\"plus\" aria-labelledby=\"h-more\" style=\"padding-top:0\"><div class=\"wrap more-grid\">\n  <div><h2 class=\"h2\" id=\"h-more\">Leituras adicionais<\/h2><div class=\"hubs\"><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/\">Gloss\u00e1rio de ingredientes<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/pt-pt\/catalogo-de-cosmeticos-personalizados\/seruns-rosto-marca-branca\/\">S\u00e9runs de rosto de marca branca<\/a><\/div><\/div>\n  <ul class=\"more-list\"><\/ul><\/div><\/section>\n<section class=\"sec sources\" id=\"sources\" aria-labelledby=\"h-s\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-s\">Fontes<\/h2><p class=\"lede\">Estudos revistos por pares e fontes regulamentares oficiais, consultados em 3 de novembro de 2026.<\/p>\n  <ol class=\"src\"><li id=\"src-1\"><span>Gorouhi F, Maibach HI. <em>Role of topical peptides in preventing or treating aged skin.<\/em> Int J Cosmet Sci. 2009;31(5):327-345. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1468-2494.2009.00490.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1468-2494.2009.00490.x<\/a><\/span><\/li><li id=\"src-2\"><span>Nukaly HY, Halawani IR, Irtaza HM, et al. <em>Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials.<\/em> Front Med (Lausanne). 2026;13:1618306. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.3389\/fmed.2026.1618306\" target=\"_blank\" rel=\"noopener\">doi:10.3389\/fmed.2026.1618306<\/a><\/span><\/li><li id=\"src-3\"><span>Robinson LR, Fitzgerald NC, Doughty DG, et al. <em>Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.<\/em> Int J Cosmet Sci. 2005;27(3):155-160. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1467-2494.2005.00261.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1467-2494.2005.00261.x<\/a><span class=\"tag\">Procter &amp; Gamble<\/span><\/span><\/li><li id=\"src-4\"><span>Wang Y, Wang M, Xiao S, et al. <em>The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.<\/em> Am J Clin Dermatol. 2013;14(2):147-153. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1007\/s40257-013-0009-9\" target=\"_blank\" rel=\"noopener\">doi:10.1007\/s40257-013-0009-9<\/a><\/span><\/li><li id=\"src-5\"><span>Marini A, Farwick M, Grether-Beck S, et al. <em>Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects.<\/em> Exp Dermatol. 2012;21(2):140-146. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01415.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1600-0625.2011.01415.x<\/a><span class=\"tag\">Evonik (coautor)<\/span><\/span><\/li><li id=\"src-6\"><span>Lintner K, Gerstein F, Solish N. <em>A serum containing vitamins C &amp; E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis and frequently repeated auto-perception.<\/em> J Cosmet Dermatol. 2020;19(12):3262-3269. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/jocd.13770\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/jocd.13770<\/a><span class=\"tag\">KAL&#x27;IDEES \/ Alumier Labs<\/span><\/span><\/li><li id=\"src-7\"><span>Pickart L, Vasquez-Soltero JM, Margolina A. <em>GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration.<\/em> Biomed Res Int. 2015;2015:648108. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1155\/2015\/648108\" target=\"_blank\" rel=\"noopener\">doi:10.1155\/2015\/648108<\/a><span class=\"tag\">Skin Biology<\/span><\/span><\/li><li id=\"src-8\"><span>Kraeling ME, Zhou W, Wang P, Ogunsola OA. <em>In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.<\/em> Cutan Ocul Toxicol. 2015;34(1):46-52. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.3109\/15569527.2014.894521\" target=\"_blank\" rel=\"noopener\">doi:10.3109\/15569527.2014.894521<\/a><\/span><\/li><li id=\"src-9\"><span>Trzaska AH, Kotowska AM, Starr NJ, et al. <em>Permeation behaviour of cosmetic actives into the human stratum corneum.<\/em> Int J Pharm. 2026;705:127447. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1016\/j.ijpharm.2026.127447\" target=\"_blank\" rel=\"noopener\">doi:10.1016\/j.ijpharm.2026.127447<\/a><span class=\"tag\">No7 Beauty Company<\/span><\/span><\/li><li id=\"src-10\"><span>Johnson W Jr, Bergfeld WF, Belsito DV, et al. <em>Safety assessment of acetyl hexapeptide-8 amide as used in cosmetics.<\/em> Int J Toxicol. 2025;44(2_suppl):54S-63S. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1177\/10915818251340391\" target=\"_blank\" rel=\"noopener\">doi:10.1177\/10915818251340391<\/a><\/span><\/li><li id=\"src-11\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha PALMITOYL TRIPEPTIDE-38<\/em> (CAS n\u00e3o indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/85966\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-12\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha PALMITOYL PENTAPEPTIDE-4<\/em> (CAS 214047-00-4 \/ 521091-64-5). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/56913\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-13\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha PALMITOYL TRIPEPTIDE-1<\/em> (CAS 147732-56-7). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/92513\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-14\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha COPPER TRIPEPTIDE-1<\/em> (CAS n\u00e3o indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/55687\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-15\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha ACETYL HEXAPEPTIDE-8<\/em> (CAS 616204-22-9). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/54135\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-16\"><span>Comiss\u00e3o Europeia. <em>CosIng, ficha TETRAPEPTIDE-30<\/em> (CAS n\u00e3o indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/88932\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><\/ol><\/div><\/section>\n\n<div class=\"fab\" id=\"fab\"><a class=\"btn\" href=\"#consultation\">Criar um produto com p\u00e9ptidos <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div><div class=\"scrim\" id=\"scrim\"><\/div><div class=\"pop\" id=\"pop\" role=\"dialog\" aria-modal=\"false\" aria-labelledby=\"pop-n\" hidden><div class=\"pop-n\" id=\"pop-n\"><\/div><div class=\"pop-body\" id=\"pop-body\"><\/div><div class=\"pop-foot\"><a class=\"txt-link\" id=\"pop-all\" href=\"#sources\">Todas as fontes<\/a><button class=\"pop-x\" type=\"button\" id=\"pop-x\">Fechar<\/button><\/div><\/div>\n<\/div>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@graph\": [{\"@type\": \"WebPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/peptidos\/#webpage\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/peptidos\/\", \"name\": \"P\u00e9ptidos em cosm\u00e9tica: tipos, estudos e usos\", \"inLanguage\": \"pt-PT\", \"datePublished\": \"2026-11-03\", \"dateModified\": \"2026-11-03\", \"author\": {\"@type\": \"Person\", \"name\": \"Mohamed El Hjouji\", \"jobTitle\": \"Fundador e diretor executivo\", \"worksFor\": {\"@type\": \"Organization\", \"name\": \"Carmel Cosmetics Labs\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/\"}}, \"about\": {\"@type\": \"Thing\", \"name\": \"P\u00e9ptidos cosm\u00e9ticos\", \"alternateName\": [\"P\u00e9ptidos\", \"P\u00e9ptidos cosmec\u00eauticos\", \"Palmitoyl tripeptide-38\", \"Palmitoyl pentapeptide-4\", \"Acetyl hexapeptide-8\", \"Tetrapeptide-30\", \"Copper tripeptide-1\"]}, \"mainEntity\": {\"@id\": \"https:\/\/carmelcosmeticslabs.com\/pt-pt\/glossario-ingredientes-cosmeticos\/peptidos\/#term\"}, \"isPartOf\": {\"@type\": \"CollectionPage\", \"name\": \"Gloss\u00e1rio de 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S\u00e3o classificados segundo o seu modo de a\u00e7\u00e3o presumido: p\u00e9ptidos sinalizadores, transportadores, inibidores de neurotransmissores e inibidores de enzimas. No r\u00f3tulo, cada p\u00e9ptido tem o seu pr\u00f3prio nome INCI, por exemplo PALMITOYL TRIPEPTIDE-38 ou ACETYL HEXAPEPTIDE-8.\"}}, {\"@type\": \"Question\", \"name\": \"Quais s\u00e3o os benef\u00edcios dos p\u00e9ptidos para a pele?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Os ensaios citados incidem sobre rugas e linhas finas menos vis\u00edveis, manchas pigmentares mais discretas em combina\u00e7\u00e3o com um derivado de vitamina C e pele mais uniforme. O n\u00edvel de evid\u00eancia continua modesto: uma meta-an\u00e1lise de 19 ensaios conclui que o efeito nas rugas \u00e9 modesto, sobretudo devido aos p\u00e9ptidos orais. Os resultados dependem do p\u00e9ptido, da f\u00f3rmula e da dura\u00e7\u00e3o.\"}}, {\"@type\": \"Question\", \"name\": \"Que p\u00e9ptido escolher: pentapeptide-4, p\u00e9ptido de cobre ou hexapeptide-8?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Depende da promessa da gama. O palmitoyl pentapeptide-4 \u00e9 testado nas rugas e linhas finas, o acetyl hexapeptide-8 nas rugas do contorno dos olhos, o tetrapeptide-30 nas manchas pigmentares e o p\u00e9ptido de cobre na firmeza, sobretudo numa revis\u00e3o narrativa. A escolha \u00e9 feita com o formulador, em fun\u00e7\u00e3o do objetivo e do or\u00e7amento para o ativo.\"}}, {\"@type\": \"Question\", \"name\": \"Que percentagem de p\u00e9ptidos deve conter um creme ou s\u00e9rum?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Os p\u00e9ptidos s\u00e3o utilizados em doses muito baixas: 3 ppm (0.0003%) de palmitoyl pentapeptide-4 e 5 ppm (0.0005%) de palmitoyl tripeptide-38 nos ensaios citados. O painel CIR estabelece 0.005% como limite considerado seguro para o acetyl hexapeptide-8. Um \u00abelevado teor de p\u00e9ptidos\u00bb n\u00e3o garante, por isso, a efic\u00e1cia.\"}}, {\"@type\": \"Question\", \"name\": \"Os p\u00e9ptidos penetram na pele?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Muito pouco. No caso do acetyl hexapeptide-8, 0.22% da dose atinge a camada c\u00f3rnea da pele humana e n\u00e3o \u00e9 detetado p\u00e9ptido na derme. Os lipop\u00e9ptidos s\u00e3o detetados \u00e0 superf\u00edcie das c\u00e9lulas da camada c\u00f3rnea, e n\u00e3o no seu interior. \u00c9 uma limita\u00e7\u00e3o a conhecer antes de prometer um efeito em profundidade.\"}}, {\"@type\": \"Question\", \"name\": \"Com que ingredientes combinar os p\u00e9ptidos?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Nas nossas f\u00f3rmulas, s\u00e3o mais frequentemente combinados com manteiga de karit\u00e9, \u00f3leos de coco, am\u00eandoas doces e arg\u00e3o, e niacinamida. Nos ensaios citados, o tetrapeptide-30 foi testado com um derivado de vitamina C e o palmitoyl tripeptide-38 com vitamina C e vitamina E. A compatibilidade da f\u00f3rmula final \u00e9 verificada por testes de estabilidade em laborat\u00f3rio.\"}}, {\"@type\": \"Question\", \"name\": \"Os p\u00e9ptidos apresentam riscos?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Na meta-an\u00e1lise de 19 ensaios, a toler\u00e2ncia \u00e9 boa, com poucos efeitos indesej\u00e1veis. O painel CIR considera o acetyl hexapeptide-8 seguro at\u00e9 0.005%; n\u00e3o foi encontrada uma conclus\u00e3o equivalente para os outros p\u00e9ptidos aqui citados, que n\u00e3o t\u00eam restri\u00e7\u00f5es na UE. Continua a ser aconselh\u00e1vel um teste de toler\u00e2ncia da f\u00f3rmula final.\"}}, {\"@type\": \"Question\", \"name\": \"Podem fabricar um s\u00e9rum com p\u00e9ptidos para a minha marca?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Sim. O nosso laborat\u00f3rio certificado ISO 22716 disponibiliza 6 f\u00f3rmulas com p\u00e9ptidos (s\u00e9rum, cremes, cuidados capilares) personaliz\u00e1veis, ou uma f\u00f3rmula \u00e0 medida. A escolha e a dosagem dos p\u00e9ptidos s\u00e3o definidas com os nossos formuladores. 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var(--f-body)!important;color:#fff!important;background:var(--deep)!important;border:0!important;border-radius:99px!important;padding:19px 26px!important;min-height:58px;cursor:pointer;box-shadow:0 14px 30px -14px rgb(16 58 53\/.7)!important;transition:transform .16s cubic-bezier(.23,1,.32,1),background-color .2s ease}\n@media (hover:hover) and (pointer:fine){body .lpf-card button.wpforms-submit:hover{background:var(--teal)!important}}\nbody .lpf-card button.wpforms-submit:active{transform:scale(.98)}\nbody .lpf-card .wpforms-error,body .lpf-card label.wpforms-error,body .lpf-card em.wpforms-error{display:block;color:#b3261e!important;font-size:12.5px!important;margin-top:5px!important}\nbody .lpf-card input.wpforms-error,body .lpf-card select.wpforms-error,body .lpf-card textarea.wpforms-error{border-color:#d26a5f!important}\nbody .lpf-card .wpforms-confirmation-container-full{background:var(--mint)!important;border:0!important;border-radius:18px!important;color:var(--ink)!important;padding:22px!important}\n@media (max-width:520px){body .lpf-card .wpforms-field-name .wpforms-field-row{grid-template-columns:1fr}}\n<\/style><div class=\"dv-card-head\"><img loading=\"lazy\" class=\"dv-avatar\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/09\/lancer-marque-cosmetique-etape-1-expert-carmel-768x953.webp\" alt=\"Especialista de produto da Carmel Cosmetics Labs com uma fundadora de marca\" width=\"768\" height=\"953\" loading=\"lazy\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><div><h2>Fale-nos do seu projeto<\/h2><p>Um especialista de produto analisa o seu pedido e contacta-o pelo canal da sua prefer\u00eancia.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-328cef7 dv-form eael-wpforms-labels-yes eael-wpforms-form-button-custom elementor-widget elementor-widget-eael-wpforms\" data-id=\"328cef7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-wpforms.default\">\n\t\t\t\t\t            <div class=\"eael-contact-form eael-wpforms eael-wpforms-align-default\">\n                                <div class=\"wpforms-container wpforms-container-full wpforms-render-modern\" id=\"wpforms-52945\"><form id=\"wpforms-form-52945\" class=\"wpforms-validate wpforms-form wpforms-ajax-form\" data-formid=\"52945\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/pt-pt\/wp-json\/wp\/v2\/pages\/62074\" data-token=\"8ed2d31dd0b35b291025383df9d17ecc\" data-token-time=\"1794438391\"><div class=\"wpforms-head-container\"><div class=\"wpforms-title\">Lead PT \u2013 Demande de devis<\/div><\/div><noscript class=\"wpforms-error-noscript\">Please enable JavaScript in your browser to complete this form.<\/noscript><div id=\"wpforms-error-noscript\" style=\"display: none;\">Please enable JavaScript in your browser to complete this form.<\/div><div class=\"wpforms-field-container\"><div id=\"wpforms-52945-field_0-container\" class=\"wpforms-field wpforms-field-name\" data-field-type=\"name\" data-field-id=\"0\"><fieldset><legend class=\"wpforms-field-label wpforms-label-hide\" aria-hidden=\"false\">Nome <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><div class=\"wpforms-field-row wpforms-field-large\"><div class=\"wpforms-field-row-block wpforms-first wpforms-one-half\"><input type=\"text\" id=\"wpforms-52945-field_0\" class=\"wpforms-field-name-first wpforms-field-required\" name=\"wpforms[fields][0][first]\" placeholder=\"Nome pr\u00f3prio\" aria-errormessage=\"wpforms-52945-field_0-error\" required><label for=\"wpforms-52945-field_0\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Pr\u00e9nom<\/label><\/div><div class=\"wpforms-field-row-block wpforms-one-half\"><input type=\"text\" id=\"wpforms-52945-field_0-last\" class=\"wpforms-field-name-last wpforms-field-required\" name=\"wpforms[fields][0][last]\" placeholder=\"Apelido\" aria-errormessage=\"wpforms-52945-field_0-last-error\" required><label for=\"wpforms-52945-field_0-last\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Nom<\/label><\/div><\/div><\/fieldset><\/div><div id=\"wpforms-52945-field_1-container\" class=\"wpforms-field wpforms-field-email\" data-field-type=\"email\" data-field-id=\"1\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-52945-field_1\" aria-hidden=\"false\">E-mail <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"email\" id=\"wpforms-52945-field_1\" class=\"wpforms-field-large wpforms-field-required\" name=\"wpforms[fields][1]\" placeholder=\"O seu e-mail\" spellcheck=\"false\" aria-errormessage=\"wpforms-52945-field_1-error\" required><\/div><div id=\"wpforms-52945-field_3-container\" class=\"wpforms-field wpforms-field-phone\" data-field-type=\"phone\" data-field-id=\"3\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-52945-field_3\" aria-hidden=\"false\">Telefone <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"tel\" id=\"wpforms-52945-field_3\" class=\"wpforms-field-large wpforms-field-required wpforms-smart-phone-field\" data-rule-smart-phone-field=\"true\" name=\"wpforms[fields][3]\" placeholder=\"O seu telefone\" aria-label=\"Telefone\" aria-errormessage=\"wpforms-52945-field_3-error\" required><\/div><div id=\"wpforms-52945-field_4-container\" class=\"wpforms-field wpforms-field-select wpforms-field-select-style-modern\" data-field-type=\"select\" data-field-id=\"4\"><label class=\"wpforms-field-label\" for=\"wpforms-52945-field_4\">Meio de contacto preferido <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><select id=\"wpforms-52945-field_4\" class=\"wpforms-field-large wpforms-field-required choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-large\" data-search-enabled=\"\" name=\"wpforms[fields][4]\" required=\"required\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'>Escolha o seu meio de contacto preferido<\/option><option value=\"WhatsApp\"  class=\"choice-1 depth-1\"  >WhatsApp<\/option><option value=\"E-mail\"  class=\"choice-2 depth-1\"  >E-mail<\/option><option value=\"Chamada telef\u00f3nica\"  class=\"choice-3 depth-1\"  >Chamada telef\u00f3nica<\/option><\/select><\/div><div id=\"wpforms-52945-field_2-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-type=\"textarea\" data-field-id=\"2\"><label class=\"wpforms-field-label\" for=\"wpforms-52945-field_2\">Descreva brevemente o seu projeto: <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><textarea id=\"wpforms-52945-field_2\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][2]\" placeholder=\"Contexto do projeto, tipo de produtos, data prevista de lan\u00e7amento, mercado(s) de destino, etc.\" aria-errormessage=\"wpforms-52945-field_2-error\" required><\/textarea><\/div><div id=\"wpforms-52945-field_5-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_source\" data-field-type=\"hidden\" data-field-id=\"5\"><input type=\"hidden\" id=\"wpforms-52945-field_5\" name=\"wpforms[fields][5]\"><\/div><div id=\"wpforms-52945-field_6-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_medium\" data-field-type=\"hidden\" data-field-id=\"6\"><input type=\"hidden\" id=\"wpforms-52945-field_6\" name=\"wpforms[fields][6]\"><\/div><div id=\"wpforms-52945-field_7-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_campaign\" data-field-type=\"hidden\" data-field-id=\"7\"><input type=\"hidden\" id=\"wpforms-52945-field_7\" name=\"wpforms[fields][7]\"><\/div><div id=\"wpforms-52945-field_8-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_term\" 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