{"id":57411,"date":"2026-11-03T20:39:27","date_gmt":"2026-11-03T20:39:27","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?page_id=57411"},"modified":"2026-11-09T08:27:30","modified_gmt":"2026-11-09T08:27:30","slug":"dioxido-de-titanio","status":"publish","type":"page","link":"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/dioxido-de-titanio\/","title":{"rendered":"Di\u00f3xido de titanio"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"57411\" class=\"elementor elementor-57411 elementor-56001 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-f12ac45 e-flex e-con-full e-con e-parent\" data-id=\"f12ac45\" data-element_type=\"container\" data-e-type=\"container\" id=\"ing-dioxyde-de-titane\">\n\t\t\t\t<div class=\"elementor-element elementor-element-197330f elementor-widget 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svg{width:20px;height:20px;flex:none;color:var(--deep-muted)}\n@media (max-width:900px){.ig .c-grid{grid-template-columns:1fr;gap:32px}}\n@media (max-width:560px){.ig form.lead{grid-template-columns:1fr;padding:20px}}\n@media (prefers-reduced-motion:reduce){.ig *,.ig *::details-content,.ig .pop,.ig .scrim,.ig .fab{transition:none!important}}\n.ig .hero h1.h1-long{font-size:clamp(38px,4.6vw,60px);line-height:1.02}\n.ig .pins-list{display:none;list-style:none;margin:0 0 20px;padding:0;order:-1}\n.ig .pins-list li{display:flex;gap:12px;align-items:baseline;margin-bottom:10px;font-size:14px;line-height:1.4;color:var(--ink-2)}\n.ig .pins-list strong{font:600 22px\/1 var(--f-display);color:var(--teal-strong);min-width:72px}\n.ig .scale.dense{display:flex;flex-direction:column;padding-top:0}\n.ig .scale.dense .pins-list{display:block}\n.ig .scale.dense .track .pin{display:none}\n@media (max-width:560px){.ig .scale{display:flex;flex-direction:column;padding-top:0}.ig .pins-list{display:block}.ig .track .pin{display:none}}\n<\/style>\n<div class=\"ig\" data-ing=\"dioxyde-de-titane\" lang=\"es\" data-copy=\"Copiar\" data-copied=\"Copiado\">\n<nav class=\"crumbs wrap\" aria-label=\"Ruta de navegaci\u00f3n\"><ol>\n  <li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/\">Inicio<\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">Glosario de ingredientes<\/a><\/li><li aria-current=\"page\">Di\u00f3xido de titanio<\/li><\/ol><\/nav>\n<header class=\"wrap hero\" id=\"top\">\n  <div class=\"hero-copy\">\n    <h1 class=\"h1-long\">Di\u00f3xido de titanio (CI 77891)<\/h1>\n    <p class=\"brief\">El di\u00f3xido de titanio es un \u00f3xido inorg\u00e1nico blanco, filtro UV (anexo VI) y colorante CI 77891 (anexo IV)<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a>. El reglamento lo autoriza hasta el 25% como filtro, incluida la forma nano bajo condiciones de pureza, estructura cristalina y tama\u00f1o<a class=\"ref\" href=\"#src-2\">2<\/a>. Se excluyen las aplicaciones que expongan los pulmones por inhalaci\u00f3n para la forma nano, y los polvos finos se regulan por separado<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p>\n    <div class=\"byline\"><span class=\"avatar\" aria-hidden=\"true\">ME<\/span>\n      <span><strong>Mohamed El Hjouji<\/strong>Fundador y director ejecutivo \u00b7 Actualizado <time datetime=\"2026-11-03\">3 de noviembre de 2026<\/time> \u00b7 Tiempo de lectura 12 min<\/span><\/div>\n    <div class=\"actions\">\n      <a class=\"btn\" href=\"#consultation\">Crear un producto con di\u00f3xido de titanio <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a>\n      <a class=\"btn-ghost\" href=\"#recherche\">Consultar los estudios<\/a>\n    <\/div>\n  <\/div>\n  <figure class=\"hero-photo\"><img fetchpriority=\"high\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel.webp\" srcset=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel-300x224.webp 300w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel-441x329.webp 441w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel-768x574.webp 768w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel-990x740.webp 990w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel-1024x765.webp 1024w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel.webp 1400w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/dioxyde-de-titane-ingredient-cosmetique-carmel.webp 1400w\" sizes=\"(max-width:900px) 92vw, 46vw\" width=\"1400\" height=\"1046\" alt=\"Polvo blanco de di\u00f3xido de titanio en vista macro sobre una superficie de cer\u00e1mica verde salvia\" fetchpriority=\"high\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><\/figure>\n<\/header>\n<div class=\"bar\" id=\"bar\"><div class=\"wrap bar-in\">\n  <nav aria-label=\"En esta p\u00e1gina\"><ul><li><a href=\"#identite\">Identidad<\/a><\/li><li><a href=\"#recherche\">Investigaci\u00f3n<\/a><\/li><li><a href=\"#concentrations\">Concentraciones<\/a><\/li><li><a href=\"#produits\">Productos<\/a><\/li><li><a href=\"#comparatif\">Comparaci\u00f3n<\/a><\/li><li><a href=\"#faq\">Preguntas<\/a><\/li><li><a href=\"#plus\">Lecturas<\/a><\/li><li><a href=\"#sources\">Fuentes<\/a><\/li><\/ul><\/nav>\n  <a class=\"btn sm\" href=\"#consultation\" tabindex=\"-1\">Crear mi producto <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div>\n  <span class=\"bar-prog\" id=\"prog\" aria-hidden=\"true\"><\/span><\/div>\n<section class=\"sec\" id=\"identite\" aria-labelledby=\"h-id\"><div class=\"wrap id-grid\">\n  <div><h2 class=\"h2\" id=\"h-id\">Di\u00f3xido de titanio de un vistazo<\/h2>\n  <p class=\"lede\">Entrada de nuestro <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">glosario de ingredientes cosm\u00e9ticos<\/a>. Datos normativos de la base CosIng de la Comisi\u00f3n Europea<a class=\"ref\" href=\"#src-1\">1<\/a> y del Reglamento (CE) 1223\/2009<a class=\"ref\" href=\"#src-2\">2<\/a>, en su versi\u00f3n consolidada a 1 de mayo de 2025. Copie los identificadores con un clic para sus expedientes.<\/p><\/div>\n  <dl class=\"spec\"><div><dt>Nombre INCI<\/dt><dd><span class=\"\">TITANIUM DIOXIDE<\/span><button class=\"copy\" type=\"button\" data-copy=\"TITANIUM DIOXIDE\" aria-label=\"Copiar: Nombre INCI\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copiar<\/button><small>Para el etiquetado como colorante, el nombre INCI que debe utilizarse es CI 77891<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>Otros nombres<\/dt><dd>CI 77891<small>Di\u00f3xido de titanio (CI 77891) en CosIng<a class=\"ref\" href=\"#src-1\">1<\/a>; di\u00f3xido de titanio (nano) para la forma nano en el anexo VI<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>N\u00famero CAS<\/dt><dd><span class=\"num\">13463-67-7<\/span><button class=\"copy\" type=\"button\" data-copy=\"13463-67-7\" aria-label=\"Copiar: N\u00famero CAS\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copiar<\/button><small>El anexo VI tambi\u00e9n cita los CAS 1317-70-0 y 1317-80-2<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>N\u00famero CE<\/dt><dd><span class=\"num\">236-675-5<\/span><button class=\"copy\" type=\"button\" data-copy=\"236-675-5\" aria-label=\"Copiar: N\u00famero CE\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copiar<\/button><small>El anexo VI tambi\u00e9n cita 215-280-1 y 215-282-2<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>F\u00f3rmula<\/dt><dd class=\"num\">TiO\u2082<small>\u00d3xido inorg\u00e1nico<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>Funciones en CosIng<\/dt><dd>Filtro UV, absorbente UV, colorante y opacificante<small>Filtro UV, absorbente UV, colorante y opacificante en la nomenclatura europea<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>Situaci\u00f3n en la UE: filtro UV<\/dt><dd>Autorizado hasta el 25%<small>Anexo VI, entrada 27 (forma est\u00e1ndar) y 27 bis (nano, indicada como 27a en CosIng): 25% en el preparado listo para su uso. Si se combinan ambas formas, la suma no supera el 25%<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Situaci\u00f3n en la UE: colorante<\/dt><dd>Autorizado (anexo IV, entrada 143)<small>Colorante blanco CI 77891. Criterios de pureza de la Directiva 95\/45\/CE (E 171)<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Inhalaci\u00f3n<\/dt><dd>Sin aplicaciones que expongan los pulmones<small>La entrada VI\/27 bis (nano) excluye las aplicaciones que puedan dar lugar a la exposici\u00f3n de los pulmones del usuario final por inhalaci\u00f3n<a class=\"ref\" href=\"#src-2\">2<\/a>. El SCCS emiti\u00f3 dict\u00e1menes sobre la forma nano en pulverizadores (recogidos en CosIng)<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>Polvos finos<\/dt><dd>Anexo III, entrada 321<small>Di\u00f3xido de titanio en polvo que contiene un 1% o m\u00e1s de part\u00edculas con un di\u00e1metro aerodin\u00e1mico \u2264 10 \u00b5m. a) productos faciales en polvo suelto: 25%; b) productos capilares en aerosol: 1.4% (p\u00fablico general) o 1.1% (uso profesional), a) y b) \u00fanicamente en forma pigmentaria; c) otros productos: no utilizar en aplicaciones que puedan exponer los pulmones por inhalaci\u00f3n<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Condiciones de la forma nano<\/dt><dd>Entrada VI\/27 bis<small>Pureza \u2265 99%; rutilo, o rutilo con hasta un 5% de anatasa, en agregados esf\u00e9ricos, aciculares o lanceolados; tama\u00f1o mediano \u2265 30 nm (distribuci\u00f3n por n\u00famero); relaci\u00f3n de aspecto de 1 a 4.5 y superficie espec\u00edfica por volumen \u2264 460 m\u00b2\/cm\u00b3; recubrimientos indicados (s\u00edlice, al\u00famina, silanos, dimeticona, glicerina, \u00e1cido este\u00e1rico...); actividad fotocatal\u00edtica \u2264 10% de la referencia sin recubrimiento; fotoestabilidad en la f\u00f3rmula final. Las combinaciones de al\u00famina y di\u00f3xido de manganeso no se utilizan en los labios<a class=\"ref\" href=\"#src-2\">2<\/a>. El nombre va seguido de [nano] en la lista de ingredientes<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Al\u00e9rgeno que debe declararse<\/dt><dd>No<small>No figura en la lista de sustancias alerg\u00e9nicas de fragancias del Reglamento 2023\/1545<a class=\"ref\" href=\"#src-3\">3<\/a><\/small><\/dd><\/div><div><dt>Seguridad<\/dt><dd>Cuatro dict\u00e1menes del SCCS recogidos<small>Tres de ellos sobre la forma nano (pulverizadores y recubrimientos)<a class=\"ref\" href=\"#src-1\">1<\/a>. Seg\u00fan la revisi\u00f3n de 2019, no presenta riesgo en la aplicaci\u00f3n cut\u00e1nea hasta el 25%<a class=\"ref\" href=\"#src-4\">4<\/a><\/small><\/dd><\/div><\/dl><\/div><\/section>\n<section class=\"sec research\" id=\"recherche\" aria-labelledby=\"h-r\"><div class=\"wrap\">\n  <div class=\"r-head\"><div><h2 class=\"h2\" id=\"h-r\">Qu\u00e9 dice la investigaci\u00f3n<\/h2>\n  <p class=\"lede\">Cada resultado indica el protocolo y el nivel de evidencia. Cuanto mayor sea el nivel, m\u00e1s aplicable ser\u00e1 el resultado a una f\u00f3rmula acabada.<\/p><\/div><\/div>\n  <div class=\"r-tools\"><div class=\"seg\" role=\"group\" aria-label=\"Filtrar por \u00e1rea\" id=\"rfilter\"><button type=\"button\" aria-pressed=\"true\" data-d=\"all\">Todos <span>7<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"solaire\">Protecci\u00f3n solar <span>3<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"secu\">Seguridad <span>4<\/span><\/button><\/div><div class=\"legend\" aria-label=\"Niveles de evidencia\"><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n o consenso<\/span><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratorio<\/span><\/div><\/div>\n  <div class=\"domain\" data-d=\"solaire\"><h3>Protecci\u00f3n solar<span>Filtros UV<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Menor atenuaci\u00f3n de los UVA largos que el \u00f3xido de zinc<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Laboratorio y piel humana<\/span><\/div><div class=\"meta\"><span>F\u00f3rmulas modelo: 5% de di\u00f3xido de titanio, 5% de \u00f3xido de zinc y 3% de avobenzona<\/span><span>Absorbancia in vitro y factor de protecci\u00f3n UVA en piel humana<\/span><span>Autores vinculados a un fabricante de productos de salud para el consumidor<\/span><\/div><p>El di\u00f3xido de titanio al 5% aten\u00faa menos los UVA por encima de 360 nm que el \u00f3xido de zinc al 5% o la avobenzona al 3%. Con un factor de protecci\u00f3n solar comparable, sus productos presentan factores UVA inferiores. Los autores concluyen que no sustituye a ninguno de los dos para un nivel elevado de protecci\u00f3n UVA<a class=\"ref\" href=\"#src-5\">5<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Al 25%, eficacia UVA pr\u00f3xima a la del mejor filtro org\u00e1nico ensayado<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratorio<\/span><\/div><div class=\"meta\"><span>Emulsi\u00f3n de aceite en agua, ensayo in vitro<\/span><span>Siete filtros UVA org\u00e1nicos y formas recubiertas de di\u00f3xido de titanio<\/span><span>Di\u00f3xido de titanio al 25%<\/span><\/div><p>El mejor filtro UVA org\u00e1nico ensayado (anisotriazina al 10%) alcanza un factor PF-UVA de 11.82, comparable al de las formas de di\u00f3xido de titanio utilizadas al 25%. Seg\u00fan el filtro elegido, las cremas son m\u00e1s o menos eficaces<a class=\"ref\" href=\"#src-6\">6<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>La medici\u00f3n del factor de protecci\u00f3n solar var\u00eda entre laboratorios<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><\/div><div class=\"meta\"><span>32 productos, 12 laboratorios<\/span><span>Ensayo multic\u00e9ntrico, norma ISO 24444<\/span><\/div><p>La variabilidad entre laboratorios es proporcional al factor: cuanto mayor es, mayor es la dispersi\u00f3n. Los autores la consideran superior a lo que esperan el p\u00fablico y los reguladores<a class=\"ref\" href=\"#src-7\">7<\/a>. Por tanto, el factor de un producto depende de su f\u00f3rmula y del m\u00e9todo de ensayo, no de un solo filtro.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"secu\"><h3>Seguridad e inhalaci\u00f3n<span>Revisiones y evaluaciones<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Seguro en la piel hasta el 25%, desaconsejado cuando puede inhalarse<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n (coautor de la industria)<\/span><\/div><div class=\"meta\"><span>Revisi\u00f3n de 2019 sobre el di\u00f3xido de titanio nano<\/span><span>Resumen de los dict\u00e1menes del SCCS<\/span><\/div><p>La mayor\u00eda de los estudios en humanos y animales muestra que el di\u00f3xido de titanio nano no supera las capas externas de la piel ni alcanza la circulaci\u00f3n sist\u00e9mica, tanto en piel intacta como da\u00f1ada. El SCCS lo considera no sensibilizante, como m\u00e1ximo ligeramente irritante y sin pruebas de carcinogenicidad por v\u00eda cut\u00e1nea. No presenta riesgo en la piel hasta el 25%, pero el SCCS no recomienda su uso en formulaciones que puedan exponer los pulmones (pulverizadores y polvos), ya que se ha observado inflamaci\u00f3n pulmonar en animales<a class=\"ref\" href=\"#src-4\">4<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Las nanopart\u00edculas permanecen en la superficie de la piel<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n<\/span><\/div><div class=\"meta\"><span>Revisi\u00f3n de 2015<\/span><span>Nanopart\u00edculas de \u00f3xidos met\u00e1licos en protectores solares<\/span><\/div><p>Todos los estudios concluyen que la gran mayor\u00eda de las nanopart\u00edculas permanece en la superficie. Los resultados sobre un posible paso a las capas vivas de la piel son dispares, debido a las grandes diferencias entre protocolos<a class=\"ref\" href=\"#src-8\">8<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Carcinogenicidad pulmonar: pruebas mecan\u00edsticas insuficientes<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n sistem\u00e1tica<\/span><\/div><div class=\"meta\"><span>346 estudios evaluados, 206 de buena calidad<\/span><span>Nanopart\u00edculas de di\u00f3xido de titanio, in vitro e in vivo<\/span><\/div><p>Los estudios ofrecen principalmente un grado de confianza entre moderado y alto para la genotoxicidad, el estr\u00e9s oxidativo y la inflamaci\u00f3n cr\u00f3nica. Los autores concluyen que las nanopart\u00edculas podr\u00edan inducir inflamaci\u00f3n cr\u00f3nica y estr\u00e9s oxidativo, pero que las pruebas mecan\u00edsticas de carcinogenicidad pulmonar son insuficientes por la gran variedad de part\u00edculas y protocolos<a class=\"ref\" href=\"#src-9\">9<\/a>. Es para esta v\u00eda, la inhalaci\u00f3n, para la que el reglamento establece restricciones.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Sin diferencias entre las formas nano y micro, seg\u00fan autores de la industria<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n (autores de la industria)<\/span><\/div><div class=\"meta\"><span>Revisi\u00f3n de 2012<\/span><span>Autores de un fabricante de cosm\u00e9ticos<\/span><\/div><p>Seg\u00fan esta revisi\u00f3n, las nanopart\u00edculas insolubles de di\u00f3xido de titanio y \u00f3xido de zinc no atraviesan la piel humana, sin diferencias de seguridad entre las formas micro y nano<a class=\"ref\" href=\"#src-10\">10<\/a>. Los autores trabajan para un fabricante de cosm\u00e9ticos.<\/p><\/article><\/div><\/div>\n  <p class=\"frame\">Esta ficha resume la bibliograf\u00eda publicada sobre un ingrediente cosm\u00e9tico. No describe el efecto de un producto acabado, que depende de su f\u00f3rmula, ni sustituye el asesoramiento m\u00e9dico. El di\u00f3xido de titanio es un filtro UV y un colorante: el factor de protecci\u00f3n de un producto depende de la f\u00f3rmula completa y del m\u00e9todo de medici\u00f3n. Aqu\u00ed no se promete ning\u00fan factor. Varias fuentes cuentan con autores vinculados a fabricantes, como se indica en la lista de fuentes.<\/p><\/div><\/section>\n<section class=\"sec\" id=\"concentrations\" aria-labelledby=\"h-c\"><div class=\"wrap dose\">\n  <div><h2 class=\"h2\" id=\"h-c\">Concentraciones utilizadas en los estudios<\/h2><p class=\"lede\">Ning\u00fan ensayo citado compara varias concentraciones en una misma f\u00f3rmula. El estudio modelo sobre los UVA utiliza un 5%<a class=\"ref\" href=\"#src-5\">5<\/a> y un ensayo in vitro, un 25%<a class=\"ref\" href=\"#src-6\">6<\/a>. El reglamento fija un m\u00e1ximo del 25% como filtro UV, sumando las formas est\u00e1ndar y nano<a class=\"ref\" href=\"#src-2\">2<\/a>. El factor obtenido depende de la f\u00f3rmula ensayada, no solo de la concentraci\u00f3n.<\/p><\/div>\n  <div class=\"scale\" role=\"img\" aria-label=\"Escala de 0 a 30%: f\u00f3rmula modelo al 5%, ensayo al 25% y l\u00edmite legal del 25%\"><div class=\"track\"><div class=\"band\" style=\"left:16.6667%;width:66.6667%\"><\/div>\n  <div class=\"pin\" style=\"left:16.6667%\"><strong class=\"num\">5%<\/strong><span>F\u00f3rmula modelo para los UVA<a class=\"ref\" href=\"#src-5\">5<\/a><\/span><\/div><div class=\"pin\" style=\"left:83.3333%\"><strong class=\"num\">25%<\/strong><span>Ensayo in vitro<a class=\"ref\" href=\"#src-6\">6<\/a> y l\u00edmite legal<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/div><div class=\"ticks\"><span class=\"tick num\" style=\"left:0%\">0%<\/span><span class=\"tick num\" style=\"left:16.6667%\">5<\/span><span class=\"tick num\" style=\"left:33.3333%\">10<\/span><span class=\"tick num\" style=\"left:50%\">15<\/span><span class=\"tick num\" style=\"left:66.6667%\">20<\/span><span class=\"tick num\" style=\"left:83.3333%\">25<\/span><span class=\"tick num\" style=\"left:100%\">30%<\/span><\/div><\/div>\n  <ul class=\"pins-list\" aria-hidden=\"true\"><li><strong class=\"num\">5%<\/strong><span>F\u00f3rmula modelo para los UVA<a class=\"ref\" href=\"#src-5\">5<\/a><\/span><\/li><li><strong class=\"num\">25%<\/strong><span>Ensayo in vitro<a class=\"ref\" href=\"#src-6\">6<\/a> y l\u00edmite legal<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/li><\/ul><\/div><\/div><\/section>\n<section class=\"sec products\" id=\"produits\" aria-labelledby=\"h-p\"><div class=\"wrap\">\n  <div class=\"p-head\"><div><h2 class=\"h2\" id=\"h-p\">\u00bfQu\u00e9 productos contienen di\u00f3xido de titanio?<\/h2>\n  <p class=\"lede\">Nuestro <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/\">cat\u00e1logo de marca blanca<\/a> incluye 3 f\u00f3rmulas con di\u00f3xido de titanio: es el activo principal en 1 de ellas y un ingrediente complementario en las dem\u00e1s. Todas las categor\u00edas se pueden personalizar (f\u00f3rmula, fragancia, envase).<\/p><\/div>\n  <\/div>\n  <div class=\"p-cols\" style=\"--pc:1\"><div class=\"p-col on\" id=\"pc-corps\" role=\"tabpanel\"><h3><span class=\"count num\">3<\/span>Cuerpo<\/h3><p>Filtro mineral, junto con el \u00f3xido de zinc, de una crema solar mineral, un fluido con color y un s\u00e9rum con color del cat\u00e1logo.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/protectores-solares-aftersun-marca-blanca\/\"><span>Protectores solares y aftersun<\/span><span class=\"n\">3<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/protectores-solares-aftersun-marca-blanca\/protector-solar-mineral-marca-blanca\/\"><span>Protector solar mineral<small>Activo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><\/div>\n  <div class=\"pairs\"><p>En nuestras f\u00f3rmulas, se combina con mayor frecuencia con<\/p><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/aloe-vera\/\">Aloe vera <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/aceite-de-argan\/\">Aceite de arg\u00e1n <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/oxido-de-zinc\/\">\u00d3xido de zinc <span class=\"num\">2<\/span><\/a><span class=\"chip\">Extracto de regaliz <span class=\"num\">1<\/span><\/span><\/div>\n  <\/div><\/section>\n<section class=\"sec\" id=\"comparatif\" aria-labelledby=\"h-cmp\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-cmp\">\u00bfDi\u00f3xido de titanio, \u00f3xido de zinc o filtros org\u00e1nicos?<\/h2><p class=\"lede\">La elecci\u00f3n entre filtros minerales y org\u00e1nicos depende de cada f\u00f3rmula. Esto es lo que indican las fuentes, sin prometer ning\u00fan factor de protecci\u00f3n.<\/p>\n  <div class=\"seg c-pick\" role=\"group\" aria-label=\"Comparar con\" id=\"cpick\"><button type=\"button\" aria-pressed=\"true\" data-c=\"3\">\u00d3xido de zinc<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"4\">Filtros org\u00e1nicos<\/button><\/div>\n  <div class=\"tbl-wrap\"><table class=\"cmp\" id=\"cmp\" data-c=\"3\"><colgroup><col><col class=\"me\"><col><col><\/colgroup>\n  <thead><tr><td><\/td><th scope=\"col\">Di\u00f3xido de titanio<\/th><th scope=\"col\">\u00d3xido de zinc<\/th><th scope=\"col\">Filtros org\u00e1nicos<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Naturaleza<\/th><td>\u00d3xido inorg\u00e1nico<a class=\"ref\" href=\"#src-1\">1<\/a><\/td><td>\u00d3xido inorg\u00e1nico<a class=\"ref\" href=\"#src-11\">11<\/a><\/td><td>Mol\u00e9culas org\u00e1nicas (avobenzona, octocrileno, homosalato...)<a class=\"ref\" href=\"#src-12\">12<\/a><\/td><\/tr><tr><th scope=\"row\">Anexo VI<\/th><td>Entradas 27 y 27 bis (nano): 25%<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Entradas 30 y 30a (nano): 25%<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Una entrada por filtro, cada una con su propio l\u00edmite<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><\/tr><tr><th scope=\"row\">UVA en el laboratorio<\/th><td>Al 5%, menor atenuaci\u00f3n por encima de 360 nm<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><td>Al 5%, mejor atenuaci\u00f3n que el di\u00f3xido de titanio<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><td>Avobenzona fotoestabilizada al 3%: superior al di\u00f3xido de titanio al 5%<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Inhalaci\u00f3n y polvos<\/th><td>Forma nano: sin aplicaciones que expongan los pulmones; los polvos finos se regulan por separado (anexo III, 321)<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Sin aplicaciones que expongan los pulmones<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Condici\u00f3n espec\u00edfica de cada entrada; por ejemplo, no utilizar en pulverizadores para la tris-bifenil triazina<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><\/tr><tr><th scope=\"row\">Otro uso<\/th><td>Colorante CI 77891 (anexo IV, 143)<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Colorante CI 77947 (anexo IV, 144)<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Sin funci\u00f3n de colorante<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/section>\n<section class=\"sec\" id=\"faq\" aria-labelledby=\"h-faq\"><div class=\"wrap faq-grid\">\n  <h2 class=\"h2\" id=\"h-faq\">Preguntas frecuentes sobre di\u00f3xido de titanio<\/h2><div class=\"faq\"><details open><summary>\u00bfQu\u00e9 es el di\u00f3xido de titanio?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Es un \u00f3xido inorg\u00e1nico blanco (CAS 13463-67-7), declarado como TITANIUM DIOXIDE en el etiquetado, o CI 77891 cuando se utiliza como colorante. En CosIng, sus funciones son filtro UV, absorbente UV, colorante y opacificante<a class=\"ref\" href=\"#src-1\">1<\/a>.<\/div><\/details><details><summary>\u00bfEs seguro el di\u00f3xido de titanio?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">En la piel, la revisi\u00f3n de 2019 indica que el di\u00f3xido de titanio nano no supera las capas externas y que, seg\u00fan el SCCS, no presenta riesgo hasta el 25%<a class=\"ref\" href=\"#src-4\">4<\/a>. El punto sensible es la inhalaci\u00f3n: el SCCS no recomienda su uso en formulaciones que puedan exponer los pulmones, y el reglamento excluye la forma nano de este tipo de aplicaciones<a class=\"ref\" href=\"#src-2\">2<\/a><a class=\"ref\" href=\"#src-4\">4<\/a>. Una revisi\u00f3n sistem\u00e1tica de 2024 considera insuficientes las pruebas mecan\u00edsticas de carcinogenicidad pulmonar<a class=\"ref\" href=\"#src-9\">9<\/a>. La situaci\u00f3n del di\u00f3xido de titanio como aditivo alimentario se rige por otra normativa.<\/div><\/details><details><summary>\u00bfSe puede utilizar di\u00f3xido de titanio nano?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">S\u00ed, con condiciones: entrada VI\/27 bis, pureza \u2265 99%, rutilo (hasta un 5% de anatasa), tama\u00f1o mediano \u2265 30 nm, recubrimientos indicados, actividad fotocatal\u00edtica \u2264 10% de la referencia, fotoestabilidad y ausencia de aplicaciones que expongan los pulmones<a class=\"ref\" href=\"#src-2\">2<\/a>. El nombre va seguido de [nano] en la lista de ingredientes<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/div><\/details><details><summary>\u00bfSe puede utilizar en polvo o en un pulverizador?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Los polvos que contienen un 1% o m\u00e1s de part\u00edculas con un di\u00e1metro aerodin\u00e1mico \u2264 10 \u00b5m est\u00e1n sujetos al anexo III, entrada 321: 25% para polvos faciales sueltos y 1.4% (1.1% en uso profesional) para productos capilares en aerosol, en forma pigmentaria; los dem\u00e1s productos no deben exponer los pulmones<a class=\"ref\" href=\"#src-2\">2<\/a>. El reglamento tambi\u00e9n excluye la forma nano de cualquier aplicaci\u00f3n que exponga los pulmones<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/div><\/details><details><summary>\u00bfQu\u00e9 significa CI 77891?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Es el nombre del di\u00f3xido de titanio cuando se utiliza como colorante blanco, entrada 143 del anexo IV, con los criterios de pureza de la Directiva 95\/45\/CE (E 171)<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a>. En el etiquetado figura CI 77891 para el colorante y TITANIUM DIOXIDE para el filtro UV<a class=\"ref\" href=\"#src-1\">1<\/a>.<\/div><\/details><details><summary>\u00bfQu\u00e9 porcentaje de di\u00f3xido de titanio puede contener un producto solar?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">El l\u00edmite como filtro UV es del 25%, sumando las formas est\u00e1ndar y nano<a class=\"ref\" href=\"#src-2\">2<\/a>. Un ensayo in vitro lo utiliz\u00f3 al 25%<a class=\"ref\" href=\"#src-6\">6<\/a> y el estudio modelo sobre los UVA, al 5%<a class=\"ref\" href=\"#src-5\">5<\/a>. La concentraci\u00f3n se establece con el formulador en funci\u00f3n de la f\u00f3rmula.<\/div><\/details><details><summary>\u00bfQu\u00e9 factor de protecci\u00f3n solar se puede conseguir con di\u00f3xido de titanio?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">No se puede prometer un factor a partir de un \u00fanico ingrediente. El factor depende de la f\u00f3rmula ensayada y del m\u00e9todo: la dispersi\u00f3n entre laboratorios es mayor de lo esperado<a class=\"ref\" href=\"#src-7\">7<\/a>, y el di\u00f3xido de titanio aten\u00faa menos los UVA largos que el \u00f3xido de zinc en el estudio modelo<a class=\"ref\" href=\"#src-5\">5<\/a>. Se mide en el producto acabado.<\/div><\/details><details><summary>\u00bfPueden fabricar un producto solar mineral para mi marca?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">S\u00ed. Nuestro laboratorio <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/certificaciones-iso-22716\/\">certificado seg\u00fan ISO 22716<\/a> ofrece 3 f\u00f3rmulas con di\u00f3xido de titanio (crema, fluido y s\u00e9rum solares) que puede personalizar, o una <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/laboratorio-formulacion-cosmetica\/\">f\u00f3rmula a medida<\/a>. Las muestras son gratuitas.<\/div><\/details><\/div><\/div><\/section>\n<section class=\"sec\" id=\"plus\" aria-labelledby=\"h-more\" style=\"padding-top:0\"><div class=\"wrap more-grid\">\n  <div><h2 class=\"h2\" id=\"h-more\">Lecturas complementarias<\/h2><div class=\"hubs\"><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">Glosario de ingredientes<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/protectores-solares-aftersun-marca-blanca\/\">Protecci\u00f3n solar en marca blanca<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/laboratorio-formulacion-cosmetica\/\">Laboratorio de formulaci\u00f3n cosm\u00e9tica<\/a><\/div><\/div>\n  <ul class=\"more-list\"><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/top-10-productos-cosmeticos-marca-blanca-tendencia-vender\/\"><span><strong>Los 10 productos cosm\u00e9ticos en marca blanca para vender en 2025<\/strong><small>Las cremas solares minerales en la clasificaci\u00f3n<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/episodio-5-como-crear-marca-protector-solar-marca\/\"><span><strong>Episodio 5: c\u00f3mo crear una marca de crema solar en marca blanca<\/strong><small>P\u00f3dcast Cosmetopreneur sobre la crema solar<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/exportar-cosmeticos-marruecos-europa-normas-reglamentarias-hay-cumplir\/\"><span><strong>Exportar cosm\u00e9ticos de Marruecos a Europa: \u00bfqu\u00e9 normas cumplir?<\/strong><small>Anexos del reglamento europeo: conservantes, filtros UV y colorantes<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><\/div><\/section>\n<section class=\"sec sources\" id=\"sources\" aria-labelledby=\"h-s\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-s\">Fuentes<\/h2><p class=\"lede\">Estudios revisados por pares y fuentes normativas oficiales, consultados el 3 de noviembre de 2026.<\/p>\n  <ol class=\"src\"><li id=\"src-1\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha TITANIUM DIOXIDE<\/em> (CAS 13463-67-7, CE 236-675-5). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/38617\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-2\"><span>Reglamento (CE) n.\u00ba 1223\/2009 del Parlamento Europeo y del Consejo, de 30 de noviembre de 2009, sobre los productos cosm\u00e9ticos (texto consolidado a 1 de mayo de 2025). <a class=\"txt-link\" href=\"https:\/\/eur-lex.europa.eu\/eli\/reg\/2009\/1223\/oj\" target=\"_blank\" rel=\"noopener\">eur-lex.europa.eu<\/a><\/span><\/li><li id=\"src-3\"><span>Reglamento (UE) 2023\/1545 de la Comisi\u00f3n, de 26 de julio de 2023, en lo que respecta al etiquetado de al\u00e9rgenos de fragancias en los productos cosm\u00e9ticos. <a class=\"txt-link\" href=\"https:\/\/eur-lex.europa.eu\/eli\/reg\/2023\/1545\/oj\" target=\"_blank\" rel=\"noopener\">eur-lex.europa.eu<\/a><\/span><\/li><li id=\"src-4\"><span>Dr\u00e9no B, Alexis A, Chuberre B, Marinovich M. <em>Safety of titanium dioxide nanoparticles in cosmetics.<\/em> J Eur Acad Dermatol Venereol. 2019;33 Suppl 7:34-46. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/jdv.15943\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/jdv.15943<\/a><span class=\"tag\">Coautor de un fabricante de cosm\u00e9ticos<\/span><\/span><\/li><li id=\"src-5\"><span>Beasley DG, Meyer TA. <em>Characterization of the UVA protection provided by avobenzone, zinc oxide, and titanium dioxide in broad-spectrum sunscreen products.<\/em> Am J Clin Dermatol. 2010;11(6):413-421. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.2165\/11537050-000000000-00000\" target=\"_blank\" rel=\"noopener\">doi:10.2165\/11537050-000000000-00000<\/a><span class=\"tag\">Autores vinculados a una empresa de productos de salud para el consumidor<\/span><\/span><\/li><li id=\"src-6\"><span>Couteau C, El-Boury S, Paparis E, S\u00e9bille-Rivain V, Coiffard LJ. <em>In vitro UV-A protection factor (PF-UVA) of organic and inorganic sunscreens.<\/em> Pharm Dev Technol. 2009;14(4):369-372. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1080\/10837450802683966\" target=\"_blank\" rel=\"noopener\">doi:10.1080\/10837450802683966<\/a><\/span><\/li><li id=\"src-7\"><span>Cole C, Colson B, Uhlig S. <em>The variability of in vivo sunscreen sun protection factor values.<\/em> Int J Cosmet Sci. 2025;47 Suppl 1:25-36. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/ics.70000\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/ics.70000<\/a><\/span><\/li><li id=\"src-8\"><span>Gulson B, McCall MJ, Bowman DM, Pinheiro T. <em>A review of critical factors for assessing the dermal absorption of metal oxide nanoparticles from sunscreens applied to humans, and a research strategy to address current deficiencies.<\/em> Arch Toxicol. 2015;89(11):1909-1930. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1007\/s00204-015-1564-z\" target=\"_blank\" rel=\"noopener\">doi:10.1007\/s00204-015-1564-z<\/a><\/span><\/li><li id=\"src-9\"><span>Wolf S, Sriram K, Camassa LMA, et al. <em>Systematic review of mechanistic evidence for TiO2 nanoparticle-induced lung carcinogenicity.<\/em> Nanotoxicology. 2024;18(5):437-463. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1080\/17435390.2024.2384408\" target=\"_blank\" rel=\"noopener\">doi:10.1080\/17435390.2024.2384408<\/a><\/span><\/li><li id=\"src-10\"><span>Nohynek GJ, Dufour EK. <em>Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?.<\/em> Arch Toxicol. 2012;86(7):1063-1075. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1007\/s00204-012-0831-5\" target=\"_blank\" rel=\"noopener\">doi:10.1007\/s00204-012-0831-5<\/a><span class=\"tag\">Autores de un fabricante de cosm\u00e9ticos<\/span><\/span><\/li><li id=\"src-11\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha ZINC OXIDE<\/em> (CAS 1314-13-2, CE 215-222-5). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/38968\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-12\"><span>Matta MK, Florian J, Zusterzeel R, et al. <em>Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial.<\/em> JAMA. 2020;323(3):256-267. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1001\/jama.2019.20747\" target=\"_blank\" rel=\"noopener\">doi:10.1001\/jama.2019.20747<\/a><\/span><\/li><\/ol><\/div><\/section>\n\n<div class=\"fab\" id=\"fab\"><a class=\"btn\" href=\"#consultation\">Crear un producto con di\u00f3xido de titanio <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div><div class=\"scrim\" id=\"scrim\"><\/div><div class=\"pop\" id=\"pop\" role=\"dialog\" aria-modal=\"false\" aria-labelledby=\"pop-n\" hidden><div class=\"pop-n\" id=\"pop-n\"><\/div><div class=\"pop-body\" id=\"pop-body\"><\/div><div class=\"pop-foot\"><a class=\"txt-link\" id=\"pop-all\" href=\"#sources\">Todas las fuentes<\/a><button class=\"pop-x\" type=\"button\" id=\"pop-x\">Cerrar<\/button><\/div><\/div>\n<\/div>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@graph\": [{\"@type\": \"WebPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/dioxido-de-titanio\/#webpage\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/dioxido-de-titanio\/\", \"name\": \"Di\u00f3xido de titanio (CI 77891): filtro UV y nano\", \"inLanguage\": \"es-ES\", \"datePublished\": \"2026-11-03\", \"dateModified\": \"2026-11-03\", \"author\": {\"@type\": \"Person\", \"name\": \"Mohamed El Hjouji\", \"jobTitle\": \"Fundador y director ejecutivo\", \"worksFor\": {\"@type\": \"Organization\", \"name\": \"Carmel Cosmetics Labs\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/\"}}, \"about\": {\"@type\": \"ChemicalSubstance\", \"name\": \"Di\u00f3xido de titanio\", \"alternateName\": [\"Di\u00f3xido de titanio\", \"CI 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es el di\u00f3xido de titanio?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Es un \u00f3xido inorg\u00e1nico blanco (CAS 13463-67-7), declarado como TITANIUM DIOXIDE en el etiquetado, o CI 77891 cuando se utiliza como colorante. En CosIng, sus funciones son filtro UV, absorbente UV, colorante y opacificante.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfEs seguro el di\u00f3xido de titanio?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"En la piel, la revisi\u00f3n de 2019 indica que el di\u00f3xido de titanio nano no supera las capas externas y que, seg\u00fan el SCCS, no presenta riesgo hasta el 25%. El punto sensible es la inhalaci\u00f3n: el SCCS no recomienda su uso en formulaciones que puedan exponer los pulmones, y el reglamento excluye la forma nano de este tipo de aplicaciones. Una revisi\u00f3n sistem\u00e1tica de 2024 considera insuficientes las pruebas mecan\u00edsticas de carcinogenicidad pulmonar. La situaci\u00f3n del di\u00f3xido de titanio como aditivo alimentario se rige por otra normativa.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfSe puede utilizar di\u00f3xido de titanio nano?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"S\u00ed, con condiciones: entrada VI\/27 bis, pureza \u2265 99%, rutilo (hasta un 5% de anatasa), tama\u00f1o mediano \u2265 30 nm, recubrimientos indicados, actividad fotocatal\u00edtica \u2264 10% de la referencia, fotoestabilidad y ausencia de aplicaciones que expongan los pulmones. El nombre va seguido de [nano] en la lista de ingredientes.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfSe puede utilizar en polvo o en un pulverizador?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Los polvos que contienen un 1% o m\u00e1s de part\u00edculas con un di\u00e1metro aerodin\u00e1mico \u2264 10 \u00b5m est\u00e1n sujetos al anexo III, entrada 321: 25% para polvos faciales sueltos y 1.4% (1.1% en uso profesional) para productos capilares en aerosol, en forma pigmentaria; los dem\u00e1s productos no deben exponer los pulmones. El reglamento tambi\u00e9n excluye la forma nano de cualquier aplicaci\u00f3n que exponga los pulmones.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 significa CI 77891?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Es el nombre del di\u00f3xido de titanio cuando se utiliza como colorante blanco, entrada 143 del anexo IV, con los criterios de pureza de la Directiva 95\/45\/CE (E 171). En el etiquetado figura CI 77891 para el colorante y TITANIUM DIOXIDE para el filtro UV.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 porcentaje de di\u00f3xido de titanio puede contener un producto solar?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"El l\u00edmite como filtro UV es del 25%, sumando las formas est\u00e1ndar y nano. Un ensayo in vitro lo utiliz\u00f3 al 25% y el estudio modelo sobre los UVA, al 5%. La concentraci\u00f3n se establece con el formulador en funci\u00f3n de la f\u00f3rmula.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 factor de protecci\u00f3n solar se puede conseguir con di\u00f3xido de titanio?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No se puede prometer un factor a partir de un \u00fanico ingrediente. El factor depende de la f\u00f3rmula ensayada y del m\u00e9todo: la dispersi\u00f3n entre laboratorios es mayor de lo esperado, y el di\u00f3xido de titanio aten\u00faa menos los UVA largos que el \u00f3xido de zinc en el estudio modelo. Se mide en el producto acabado.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfPueden fabricar un producto solar mineral para mi marca?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"S\u00ed. Nuestro laboratorio certificado seg\u00fan ISO 22716 ofrece 3 f\u00f3rmulas con di\u00f3xido de titanio (crema, fluido y s\u00e9rum solares) que puede personalizar, o una f\u00f3rmula a medida. Las muestras son gratuitas.\"}}]}]}<\/script>\n<script>(function(){\n  var $=function(s,c){return (c||document).querySelector(s)}, $$=function(s,c){return [].slice.call((c||document).querySelectorAll(s))};\n  var root=document.querySelector('.ig')||document.documentElement;\n\n  \/* Clear the site's sticky header and mobile bottom menu when present (WordPress). *\/\n  function measure(){\n    var h=0,b=0,hd=$('.elementor-location-header'),bm=$('.wp-bottom-menu');\n    if(hd&&\/sticky|fixed\/.test(getComputedStyle(hd).position))h=hd.getBoundingClientRect().height;\n    if(bm){var cs=getComputedStyle(bm);if(cs.display!=='none'&&cs.visibility!=='hidden')b=bm.getBoundingClientRect().height;}\n    root.style.setProperty('--hdr',Math.round(h)+'px'); root.style.setProperty('--bm',Math.round(b)+'px');\n  }\n  measure(); setTimeout(measure,1200); addEventListener('resize',measure,{passive:true});\n\n  \/* Sticky bar: scrollspy, progress, CTA after hero, floating CTA on phones *\/\n  var 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var(--f-body)!important;color:#fff!important;background:var(--deep)!important;border:0!important;border-radius:99px!important;padding:19px 26px!important;min-height:58px;cursor:pointer;box-shadow:0 14px 30px -14px rgb(16 58 53\/.7)!important;transition:transform .16s cubic-bezier(.23,1,.32,1),background-color .2s ease}\n@media (hover:hover) and (pointer:fine){body .lpf-card button.wpforms-submit:hover{background:var(--teal)!important}}\nbody .lpf-card button.wpforms-submit:active{transform:scale(.98)}\nbody .lpf-card .wpforms-error,body .lpf-card label.wpforms-error,body .lpf-card em.wpforms-error{display:block;color:#b3261e!important;font-size:12.5px!important;margin-top:5px!important}\nbody .lpf-card input.wpforms-error,body .lpf-card select.wpforms-error,body .lpf-card textarea.wpforms-error{border-color:#d26a5f!important}\nbody .lpf-card .wpforms-confirmation-container-full{background:var(--mint)!important;border:0!important;border-radius:18px!important;color:var(--ink)!important;padding:22px!important}\n@media (max-width:520px){body .lpf-card .wpforms-field-name .wpforms-field-row{grid-template-columns:1fr}}\n<\/style><div class=\"dv-card-head\"><img loading=\"lazy\" class=\"dv-avatar\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/09\/lancer-marque-cosmetique-etape-1-expert-carmel-768x953.webp\" alt=\"Especialista de producto de Carmel Cosmetics Labs con una fundadora de marca\" width=\"768\" height=\"953\" loading=\"lazy\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><div><h2>Cu\u00e9ntenos su proyecto<\/h2><p>Un especialista de producto estudia su solicitud y le responde por el canal que prefiera.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9800f75 dv-form eael-wpforms-labels-yes eael-wpforms-form-button-custom elementor-widget elementor-widget-eael-wpforms\" data-id=\"9800f75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-wpforms.default\">\n\t\t\t\t\t            <div class=\"eael-contact-form eael-wpforms eael-wpforms-align-default\">\n                                <div class=\"wpforms-container wpforms-container-full wpforms-render-modern\" id=\"wpforms-51144\"><form id=\"wpforms-form-51144\" class=\"wpforms-validate wpforms-form wpforms-ajax-form\" data-formid=\"51144\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/es\/wp-json\/wp\/v2\/pages\/57411\" data-token=\"8f94df23b1ccab2c62dd3b47ec22c230\" data-token-time=\"1794233083\"><div class=\"wpforms-head-container\"><div class=\"wpforms-title\">Lead ES \u2013 Demande de devis<\/div><\/div><noscript class=\"wpforms-error-noscript\">Por favor, activa JavaScript en tu navegador para completar este formulario.<\/noscript><div id=\"wpforms-error-noscript\" style=\"display: none;\">Por favor, activa JavaScript en tu navegador para completar este formulario.<\/div><div class=\"wpforms-field-container\"><div id=\"wpforms-51144-field_0-container\" class=\"wpforms-field wpforms-field-name\" data-field-type=\"name\" data-field-id=\"0\"><fieldset><legend class=\"wpforms-field-label wpforms-label-hide\" aria-hidden=\"false\">Nombre <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><div class=\"wpforms-field-row wpforms-field-large\"><div class=\"wpforms-field-row-block wpforms-first wpforms-one-half\"><input type=\"text\" id=\"wpforms-51144-field_0\" class=\"wpforms-field-name-first wpforms-field-required\" name=\"wpforms[fields][0][first]\" placeholder=\"Nombre\" aria-errormessage=\"wpforms-51144-field_0-error\" required><label for=\"wpforms-51144-field_0\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Pr\u00e9nom<\/label><\/div><div class=\"wpforms-field-row-block wpforms-one-half\"><input type=\"text\" id=\"wpforms-51144-field_0-last\" class=\"wpforms-field-name-last wpforms-field-required\" name=\"wpforms[fields][0][last]\" placeholder=\"Apellidos\" aria-errormessage=\"wpforms-51144-field_0-last-error\" required><label for=\"wpforms-51144-field_0-last\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Nom<\/label><\/div><\/div><\/fieldset><\/div><div id=\"wpforms-51144-field_1-container\" class=\"wpforms-field wpforms-field-email\" data-field-type=\"email\" data-field-id=\"1\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-51144-field_1\" aria-hidden=\"false\">Correo electr\u00f3nico <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"email\" id=\"wpforms-51144-field_1\" class=\"wpforms-field-large wpforms-field-required\" name=\"wpforms[fields][1]\" placeholder=\"Su correo electr\u00f3nico\" spellcheck=\"false\" aria-errormessage=\"wpforms-51144-field_1-error\" required><\/div><div id=\"wpforms-51144-field_3-container\" class=\"wpforms-field wpforms-field-phone\" data-field-type=\"phone\" data-field-id=\"3\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-51144-field_3\" aria-hidden=\"false\">Tel\u00e9fono <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"tel\" id=\"wpforms-51144-field_3\" class=\"wpforms-field-large wpforms-field-required wpforms-smart-phone-field\" data-rule-smart-phone-field=\"true\" name=\"wpforms[fields][3]\" placeholder=\"Su tel\u00e9fono\" aria-label=\"Tel\u00e9fono\" aria-errormessage=\"wpforms-51144-field_3-error\" required><\/div><div id=\"wpforms-51144-field_4-container\" class=\"wpforms-field wpforms-field-select wpforms-field-select-style-modern\" data-field-type=\"select\" data-field-id=\"4\"><label class=\"wpforms-field-label\" for=\"wpforms-51144-field_4\">Medio de contacto preferido <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><select id=\"wpforms-51144-field_4\" class=\"wpforms-field-large wpforms-field-required choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-large\" data-search-enabled=\"\" name=\"wpforms[fields][4]\" required=\"required\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'>Elija su medio de contacto preferido<\/option><option value=\"WhatsApp\"  class=\"choice-1 depth-1\"  >WhatsApp<\/option><option value=\"Correo electr\u00f3nico\"  class=\"choice-2 depth-1\"  >Correo electr\u00f3nico<\/option><option value=\"Llamada telef\u00f3nica\"  class=\"choice-3 depth-1\"  >Llamada telef\u00f3nica<\/option><\/select><\/div><div id=\"wpforms-51144-field_2-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-type=\"textarea\" data-field-id=\"2\"><label class=\"wpforms-field-label\" for=\"wpforms-51144-field_2\">Describa brevemente su proyecto: <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><textarea id=\"wpforms-51144-field_2\" class=\"wpforms-field-medium 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