{"id":57099,"date":"2026-11-03T07:15:33","date_gmt":"2026-11-03T07:15:33","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?page_id=57099"},"modified":"2026-11-09T07:33:36","modified_gmt":"2026-11-09T07:33:36","slug":"peptidos","status":"publish","type":"page","link":"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/peptidos\/","title":{"rendered":"P\u00e9ptidos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"57099\" class=\"elementor elementor-57099 elementor-54476 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-fd2b306 e-flex e-con-full e-con e-parent\" data-id=\"fd2b306\" data-element_type=\"container\" data-e-type=\"container\" id=\"ing-peptides\">\n\t\t\t\t<div class=\"elementor-element elementor-element-584961e elementor-widget elementor-widget-html\" data-id=\"584961e\" 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svg{width:20px;height:20px;flex:none;color:var(--deep-muted)}\n@media (max-width:900px){.ig .c-grid{grid-template-columns:1fr;gap:32px}}\n@media (max-width:560px){.ig form.lead{grid-template-columns:1fr;padding:20px}}\n@media (prefers-reduced-motion:reduce){.ig *,.ig *::details-content,.ig .pop,.ig .scrim,.ig .fab{transition:none!important}}\n.ig .hero h1.h1-long{font-size:clamp(38px,4.6vw,60px);line-height:1.02}\n.ig .pins-list{display:none;list-style:none;margin:0 0 20px;padding:0;order:-1}\n.ig .pins-list li{display:flex;gap:12px;align-items:baseline;margin-bottom:10px;font-size:14px;line-height:1.4;color:var(--ink-2)}\n.ig .pins-list strong{font:600 22px\/1 var(--f-display);color:var(--teal-strong);min-width:72px}\n.ig .scale.dense{display:flex;flex-direction:column;padding-top:0}\n.ig .scale.dense .pins-list{display:block}\n.ig .scale.dense .track .pin{display:none}\n@media (max-width:560px){.ig .scale{display:flex;flex-direction:column;padding-top:0}.ig .pins-list{display:block}.ig .track .pin{display:none}}\n<\/style>\n<div class=\"ig\" data-ing=\"peptides\" lang=\"es\" data-copy=\"Copiar\" data-copied=\"Copiado\">\n<nav class=\"crumbs wrap\" aria-label=\"Ruta de navegaci\u00f3n\"><ol>\n  <li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/\">Inicio<\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">Glosario de ingredientes<\/a><\/li><li aria-current=\"page\">P\u00e9ptidos<\/li><\/ol><\/nav>\n<header class=\"wrap hero\" id=\"top\">\n  <div class=\"hero-copy\">\n    <h1>P\u00e9ptidos cosm\u00e9ticos<\/h1>\n    <p class=\"brief\">Los p\u00e9ptidos cosm\u00e9ticos son cadenas cortas de amino\u00e1cidos, clasificadas en p\u00e9ptidos se\u00f1al, transportadores, inhibidores de neurotransmisores e inhibidores de enzimas<a class=\"ref\" href=\"#src-1\">1<\/a>. Los nombres INCI citados aqu\u00ed no tienen restricciones en la UE<a class=\"ref\" href=\"#src-11\">11<\/a>. Los ensayos cut\u00e1neos son breves y a menudo realizados por la industria; un metaan\u00e1lisis de 19 ensayos concluye que el efecto sobre las arrugas es modesto y se debe sobre todo a los p\u00e9ptidos orales<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p>\n    <div class=\"byline\"><span class=\"avatar\" aria-hidden=\"true\">ME<\/span>\n      <span><strong>Mohamed El Hjouji<\/strong>Fundador y director ejecutivo \u00b7 Actualizado <time datetime=\"2026-11-03\">3 de noviembre de 2026<\/time> \u00b7 Tiempo de lectura 11 min<\/span><\/div>\n    <div class=\"actions\">\n      <a class=\"btn\" href=\"#consultation\">Crear un producto con p\u00e9ptidos <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a>\n      <a class=\"btn-ghost\" href=\"#recherche\">Consultar los estudios<\/a>\n    <\/div>\n  <\/div>\n  <figure class=\"hero-photo\"><img fetchpriority=\"high\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp\" srcset=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-300x224.webp 300w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-441x329.webp 441w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-768x574.webp 768w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-990x740.webp 990w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel-1024x765.webp 1024w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp 1400w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/peptides-ingredient-cosmetique-carmel.webp 1400w\" sizes=\"(max-width:900px) 92vw, 46vw\" width=\"1400\" height=\"1046\" alt=\"P\u00e9ptidos cosm\u00e9ticos en polvo blanco, en vista macro sobre una superficie de cer\u00e1mica verde salvia, con luz rasante\" fetchpriority=\"high\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><\/figure>\n<\/header>\n<div class=\"bar\" id=\"bar\"><div class=\"wrap bar-in\">\n  <nav aria-label=\"En esta p\u00e1gina\"><ul><li><a href=\"#identite\">Identidad<\/a><\/li><li><a href=\"#recherche\">Investigaci\u00f3n<\/a><\/li><li><a href=\"#produits\">Productos<\/a><\/li><li><a href=\"#comparatif\">Comparaci\u00f3n<\/a><\/li><li><a href=\"#faq\">Preguntas<\/a><\/li><li><a href=\"#plus\">Lecturas<\/a><\/li><li><a href=\"#sources\">Fuentes<\/a><\/li><\/ul><\/nav>\n  <a class=\"btn sm\" href=\"#consultation\" tabindex=\"-1\">Crear mi producto <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div>\n  <span class=\"bar-prog\" id=\"prog\" aria-hidden=\"true\"><\/span><\/div>\n<section class=\"sec\" id=\"identite\" aria-labelledby=\"h-id\"><div class=\"wrap id-grid\">\n  <div><h2 class=\"h2\" id=\"h-id\">Los p\u00e9ptidos de un vistazo<\/h2>\n  <p class=\"lede\">Entrada de nuestro <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">glosario de ingredientes cosm\u00e9ticos<\/a>. Datos normativos de la base CosIng de la Comisi\u00f3n Europea<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a>. \u00abP\u00e9ptidos\u00bb designa una familia: cada p\u00e9ptido tiene su propio nombre INCI. Copie el de nuestras f\u00f3rmulas con un clic para su documentaci\u00f3n.<\/p><\/div>\n  <dl class=\"spec\"><div><dt>Nombre INCI del cat\u00e1logo<\/dt><dd><span class=\"\">PALMITOYL TRIPEPTIDE-38<\/span><button class=\"copy\" type=\"button\" data-copy=\"PALMITOYL TRIPEPTIDE-38\" aria-label=\"Copiar: Nombre INCI del cat\u00e1logo\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copiar<\/button><small>Producto de la reacci\u00f3n del \u00e1cido palm\u00edtico y el tripeptide-38<a class=\"ref\" href=\"#src-11\">11<\/a>. Presente en nuestro s\u00e9rum y nuestra crema con p\u00e9ptidos<\/small><\/dd><\/div><div><dt>Familia<\/dt><dd>P\u00e9ptidos<small>Cadenas cortas de amino\u00e1cidos. El prefijo palmitoyl indica una uni\u00f3n al \u00e1cido palm\u00edtico<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><\/small><\/dd><\/div><div><dt>Palmitoyl pentapeptide-4<\/dt><dd class=\"num\">214047-00-4 \/ 521091-64-5<small>N\u00fameros CAS; sin n\u00famero CE<a class=\"ref\" href=\"#src-12\">12<\/a><\/small><\/dd><\/div><div><dt>Palmitoyl tripeptide-1<\/dt><dd class=\"num\">147732-56-7<small>N\u00famero CAS<a class=\"ref\" href=\"#src-13\">13<\/a><\/small><\/dd><\/div><div><dt>Copper tripeptide-1<\/dt><dd>Sin CAS en CosIng<small>Complejo de cobre del tripeptide-1<a class=\"ref\" href=\"#src-14\">14<\/a><\/small><\/dd><\/div><div><dt>Acetyl hexapeptide-8<\/dt><dd class=\"num\">616204-22-9<small>N\u00famero CAS; p\u00e9ptido sint\u00e9tico compuesto por arginina, metionina y \u00e1cido glut\u00e1mico acetilado<a class=\"ref\" href=\"#src-15\">15<\/a><\/small><\/dd><\/div><div><dt>Tetrapeptide-30<\/dt><dd>Sin CAS en CosIng<small>P\u00e9ptido sint\u00e9tico compuesto por \u00e1cido glut\u00e1mico, lisina y prolina<a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Funci\u00f3n CosIng<\/dt><dd>Acondicionador de la piel<small>Acetyl hexapeptide-8 tambi\u00e9n es humectante y tetrapeptide-30 tambi\u00e9n protege la piel<a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Situaci\u00f3n en la UE<\/dt><dd>Sin restricciones<small>Ninguno de estos seis nombres INCI figura en los anexos del Reglamento (CE) 1223\/2009<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a><\/small><\/dd><\/div><div><dt>Al\u00e9rgeno de declaraci\u00f3n obligatoria<\/dt><dd>No<\/dd><\/div><div><dt>Seguridad<\/dt><dd>Variable seg\u00fan el p\u00e9ptido<small>Panel CIR: acetyl hexapeptide-8 seguro hasta el 0,005 %<a class=\"ref\" href=\"#src-10\">10<\/a>. No se ha encontrado una conclusi\u00f3n para los dem\u00e1s p\u00e9ptidos citados<\/small><\/dd><\/div><\/dl><\/div><\/section>\n<section class=\"sec research\" id=\"recherche\" aria-labelledby=\"h-r\"><div class=\"wrap\">\n  <div class=\"r-head\"><div><h2 class=\"h2\" id=\"h-r\">Qu\u00e9 dice la investigaci\u00f3n<\/h2>\n  <p class=\"lede\">Cada resultado indica el protocolo y el nivel de evidencia. Cuanto mayor sea el nivel, m\u00e1s aplicable ser\u00e1 el resultado a una f\u00f3rmula acabada.<\/p><\/div><\/div>\n  <div class=\"r-tools\"><div class=\"seg\" role=\"group\" aria-label=\"Filtrar por \u00e1rea\" id=\"rfilter\"><button type=\"button\" aria-pressed=\"true\" data-d=\"all\">Todos <span>9<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"visage\">Rostro <span>5<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"derm\">Revisiones <span>4<\/span><\/button><\/div><div class=\"legend\" aria-label=\"Niveles de evidencia\"><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n o consenso<\/span><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratorio<\/span><\/div><\/div>\n  <div class=\"domain\" data-d=\"visage\"><h3>Piel del rostro<span>Cuidado de la piel<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Palmitoyl pentapeptide-4: menos arrugas y l\u00edneas de expresi\u00f3n en 12 semanas<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><\/div><div class=\"meta\"><span>3 ppm (0,0003 %)<\/span><span>12 semanas<\/span><span>93 mujeres de 35 a 55 a\u00f1os<\/span><span>Doble ciego, comparaci\u00f3n entre mitades del rostro<\/span><\/div><p>Mejora significativa de las arrugas y las l\u00edneas de expresi\u00f3n frente al placebo, seg\u00fan el an\u00e1lisis instrumental de im\u00e1genes y la evaluaci\u00f3n de expertos. El p\u00e9ptido se tolera bien. Ensayo realizado por un fabricante<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Acetyl hexapeptide-8: arrugas del contorno de ojos en 4 semanas<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><\/div><div class=\"meta\"><span>2 aplicaciones al d\u00eda<\/span><span>4 semanas<\/span><span>60 voluntarios chinos<\/span><span>Aleatorizado, proporci\u00f3n de 3 a 1 frente a placebo<\/span><\/div><p>Eficacia antiarrugas global del 48,9 % en el grupo con p\u00e9ptido, frente al 0 % con placebo. La rugosidad medida en r\u00e9plicas de silicona disminuye con el p\u00e9ptido, pero no con el placebo<a class=\"ref\" href=\"#src-4\">4<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Tetrapeptide-30: manchas pigmentarias menos visibles, en combinaci\u00f3n<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><\/div><div class=\"meta\"><span>P\u00e9ptido + derivado de vitamina C<\/span><span>6 a 8 semanas<\/span><span>39, 19 y 27 voluntarios<\/span><span>Doble ciego frente al veh\u00edculo<\/span><\/div><p>Las manchas del rostro se aten\u00faan tras 6 semanas con la combinaci\u00f3n, m\u00e1s que con el p\u00e9ptido o el derivado de vitamina C por separado. En 27 mujeres japonesas, la combinaci\u00f3n reduce la pigmentaci\u00f3n un 26 % y un 18 % seg\u00fan la puntuaci\u00f3n SCINEXA. En el laboratorio, el p\u00e9ptido limita la expresi\u00f3n de genes de pigmentaci\u00f3n tras la exposici\u00f3n a UVB<a class=\"ref\" href=\"#src-5\">5<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Palmitoyl tripeptide-38: un s\u00e9rum antioxidante y una piel m\u00e1s uniforme<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Ensayo cl\u00ednico<\/span><\/div><div class=\"meta\"><span>5 ppm (0,0005 %) con vitamina C al 15 % y acetato de tocoferilo<\/span><span>56 d\u00edas, 1 vez al d\u00eda<\/span><span>Abierto, sin placebo<\/span><span>Mujeres de 40 a\u00f1os o m\u00e1s<\/span><\/div><p>La rugosidad disminuye entre un 8 y un 9 %, las rojeces se reducen un 9 % y la uniformidad del tono mejora un 8 %. El efecto propio del p\u00e9ptido no se distingue del de los antioxidantes del s\u00e9rum. Los autores son consultores de la marca del s\u00e9rum<a class=\"ref\" href=\"#src-6\">6<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Copper tripeptide-1: evidencia principalmente narrativa<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n<\/span><\/div><div class=\"meta\"><span>Revisi\u00f3n narrativa de 2015<\/span><\/div><p>El trip\u00e9ptido GHK forma un complejo con el cobre. En cosm\u00e9tica, la revisi\u00f3n recoge una mejora de la elasticidad, la densidad y la firmeza de la piel, y menos l\u00edneas de expresi\u00f3n. No detalla ning\u00fan ensayo aqu\u00ed y sus autores est\u00e1n vinculados a una empresa del sector de los p\u00e9ptidos<a class=\"ref\" href=\"#src-7\">7<\/a>.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"derm\"><h3>Revisiones, penetraci\u00f3n y seguridad<span>Dermatolog\u00eda<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Metaan\u00e1lisis: efecto modesto sobre las arrugas, sobre todo con p\u00e9ptidos orales<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n<\/span><\/div><div class=\"meta\"><span>19 ensayos aleatorizados<\/span><span>1 341 participantes<\/span><span>P\u00e9ptidos orales y t\u00f3picos<\/span><span>Revisi\u00f3n de 2026<\/span><\/div><p>Los p\u00e9ptidos, especialmente por v\u00eda oral, mejoran la hidrataci\u00f3n y la luminosidad. El efecto combinado sobre las arrugas es modesto (diferencia media de 0,27) y se debe a los polip\u00e9ptidos orales. Los efectos sobre la elasticidad y la densidad son variables. La tolerancia es buena, con pocos acontecimientos adversos<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Cuatro familias seg\u00fan su mecanismo de acci\u00f3n<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Revisi\u00f3n<\/span><\/div><div class=\"meta\"><span>Revisi\u00f3n de 2009<\/span><\/div><p>P\u00e9ptidos se\u00f1al, inhibidores de enzimas, inhibidores de neurotransmisores y transportadores: esta es la clasificaci\u00f3n de referencia. La revisi\u00f3n solo incluye estudios controlados, ex vivo o in vivo, sobre p\u00e9ptidos o prote\u00ednas aplicados en la piel frente a los signos de la edad<a class=\"ref\" href=\"#src-1\">1<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Penetraci\u00f3n: la mayor parte permanece en el estrato c\u00f3rneo<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratorio<\/span><\/div><div class=\"meta\"><span>Acetyl hexapeptide-8 al 10 %<\/span><span>Piel humana y de cobaya, in vitro<\/span><span>24 horas<\/span><\/div><p>La mayor parte del p\u00e9ptido se elimina con el lavado. En la piel humana, el 0,22 % de la dosis se encuentra en el estrato c\u00f3rneo y el 0,01 % en la epidermis; no se detecta p\u00e9ptido en la dermis<a class=\"ref\" href=\"#src-8\">8<\/a>. Para palmitoyl tripeptide-1 y otro lipop\u00e9ptido, medidos en 3 voluntarios, los p\u00e9ptidos se encuentran en la superficie de las c\u00e9lulas del estrato c\u00f3rneo, no en su interior. Estudio realizado por una empresa cosm\u00e9tica<a class=\"ref\" href=\"#src-9\">9<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Seguridad: l\u00edmite del 0,005 % para acetyl hexapeptide-8<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Dictamen de expertos<\/span><\/div><div class=\"meta\"><span>Panel CIR de 2025<\/span><\/div><p>El panel considera seguro el ingrediente en sus usos actuales hasta el 0,005 %. Por encima de esa concentraci\u00f3n, considera que los datos son insuficientes para concluir<a class=\"ref\" href=\"#src-10\">10<\/a>.<\/p><\/article><\/div><\/div>\n  <p class=\"frame\">Esta ficha resume la bibliograf\u00eda publicada sobre una familia de ingredientes cosm\u00e9ticos. No describe el efecto de un producto acabado, que depende de su f\u00f3rmula, ni sustituye el consejo m\u00e9dico. Los p\u00e9ptidos difieren mucho entre s\u00ed: cada ensayo estudia un solo p\u00e9ptido, a veces combinado con otros activos. La mayor\u00eda de los ensayos citados fueron realizados o financiados por fabricantes; se indica en las fuentes. No se cita ning\u00fan estudio sobre el cabello.<\/p><\/div><\/section>\n\n<section class=\"sec products\" id=\"produits\" aria-labelledby=\"h-p\"><div class=\"wrap\">\n  <div class=\"p-head\"><div><h2 class=\"h2\" id=\"h-p\">\u00bfQu\u00e9 productos contienen p\u00e9ptidos?<\/h2>\n  <p class=\"lede\">Nuestro <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/\">cat\u00e1logo de marca blanca<\/a> incluye 6 f\u00f3rmulas con p\u00e9ptidos: es el activo principal en 4 de ellas y un ingrediente complementario en las dem\u00e1s. Todas las categor\u00edas se pueden personalizar (f\u00f3rmula, fragancia, envase).<\/p><\/div>\n  <div class=\"seg p-tabs\" role=\"tablist\" aria-label=\"\u00c1rea\" id=\"ptabs\"><button type=\"button\" role=\"tab\" aria-selected=\"true\" aria-controls=\"pc-visage\" data-p=\"visage\">Rostro <span>4<\/span><\/button><button type=\"button\" role=\"tab\" aria-selected=\"false\" aria-controls=\"pc-cheveux\" data-p=\"cheveux\">Cabello <span>2<\/span><\/button><\/div><\/div>\n  <div class=\"p-cols\" style=\"--pc:2\"><div class=\"p-col on\" id=\"pc-visage\" role=\"tabpanel\"><h3><span class=\"count num\">4<\/span>Rostro<\/h3><p>Activo principal del s\u00e9rum y la crema antiedad, y activo complementario de las cremas con ceramidas y centella.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/cremas-faciales-marca-blanca\/\"><span>Cremas faciales<\/span><span class=\"n\">3<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/serums-faciales-marca-blanca\/\"><span>S\u00e9rums faciales<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/serums-faciales-marca-blanca\/serum-peptidos-marca-blanca\/\"><span>S\u00e9rum de p\u00e9ptidos<small>Activo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/cremas-faciales-marca-blanca\/crema-antiedad-peptidos-marca-blanca\/\"><span>Crema antiedad con p\u00e9ptidos<small>Activo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><div class=\"p-col\" id=\"pc-cheveux\" role=\"tabpanel\"><h3><span class=\"count num\">2<\/span>Cabello<\/h3><p>Combinados con ceramidas en el acondicionador sin aclarado para rizos y con queratina hidrolizada en el s\u00e9rum capilar.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/leave-in-cremas-peinado-marca-blanca\/\"><span>Acondicionadores sin aclarado y cremas de peinado<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/serums-sprays-capilares-marca-blanca\/\"><span>S\u00e9rums y sprays capilares<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/leave-in-cremas-peinado-marca-blanca\/spray-reactivador-rizos-leave-in-marca-blanca\/\"><span>Spray reactivador de rizos leave-in<small>Activo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/serums-sprays-capilares-marca-blanca\/serum-queratina-peptidos-marca-blanca\/\"><span>S\u00e9rum de queratina y p\u00e9ptidos<small>Activo principal<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><\/div>\n  <div class=\"pairs\"><p>En nuestras f\u00f3rmulas, se combina con mayor frecuencia con<\/p><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/manteca-de-karite\/\">Manteca de karit\u00e9 <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/aceite-de-almendras-dulces\/\">Aceite de almendras dulces <span class=\"num\">3<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/aceite-de-coco\/\">Aceite de coco <span class=\"num\">3<\/span><\/a><\/div>\n  <\/div><\/section>\n<section class=\"sec\" id=\"comparatif\" aria-labelledby=\"h-cmp\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-cmp\">\u00bfPentapeptide-4, p\u00e9ptido de cobre, hexapeptide-8 o tetrapeptide-30?<\/h2><p class=\"lede\">Cuatro de los p\u00e9ptidos m\u00e1s citados, uno por mecanismo de acci\u00f3n. Son compatibles entre s\u00ed y a menudo se combinan en una misma f\u00f3rmula.<\/p>\n  <div class=\"seg c-pick\" role=\"group\" aria-label=\"Comparar con\" id=\"cpick\"><button type=\"button\" aria-pressed=\"true\" data-c=\"3\">P\u00e9ptido de cobre<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"4\">Hexapeptide-8<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"5\">Tetrapeptide-30<\/button><\/div>\n  <div class=\"tbl-wrap\"><table class=\"cmp\" id=\"cmp\" data-c=\"3\"><colgroup><col><col class=\"me\"><col><col><col><\/colgroup>\n  <thead><tr><td><\/td><th scope=\"col\">Palmitoyl pentapeptide-4<\/th><th scope=\"col\">Copper tripeptide-1<\/th><th scope=\"col\">Acetyl hexapeptide-8<\/th><th scope=\"col\">Tetrapeptide-30<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Mecanismo de acci\u00f3n descrito<\/th><td>Se\u00f1al: dise\u00f1ado para estimular la producci\u00f3n de col\u00e1geno<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Transportador: complejo del trip\u00e9ptido GHK con cobre<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Neurotransmisores: supuesta interferencia en la se\u00f1alizaci\u00f3n<a class=\"ref\" href=\"#src-8\">8<\/a><\/td><td>Pigmentaci\u00f3n: limita la expresi\u00f3n de genes de pigmentaci\u00f3n en el laboratorio<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Objetivo<\/th><td>Arrugas y l\u00edneas de expresi\u00f3n<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Elasticidad y firmeza<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Arrugas del contorno de ojos<a class=\"ref\" href=\"#src-4\">4<\/a><\/td><td>Manchas pigmentarias<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Evidencia citada<\/th><td>Ensayo de 12 semanas, 93 mujeres, 3 ppm<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Revisi\u00f3n narrativa, sin ensayo detallado<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>Ensayo de 4 semanas, 60 voluntarios<a class=\"ref\" href=\"#src-4\">4<\/a><\/td><td>Cuatro estudios frente al veh\u00edculo<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><tr><th scope=\"row\">Normativa de la UE<\/th><td>Sin restricciones<a class=\"ref\" href=\"#src-12\">12<\/a><\/td><td>Sin restricciones<a class=\"ref\" href=\"#src-14\">14<\/a><\/td><td>Sin restricciones<a class=\"ref\" href=\"#src-15\">15<\/a><\/td><td>Sin restricciones<a class=\"ref\" href=\"#src-16\">16<\/a><\/td><\/tr><tr><th scope=\"row\">Aspecto a tener en cuenta<\/th><td>Un \u00fanico ensayo citado, realizado por un fabricante<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Autores vinculados a una empresa de p\u00e9ptidos<a class=\"ref\" href=\"#src-7\">7<\/a><\/td><td>CIR: seguro hasta el 0,005 %<a class=\"ref\" href=\"#src-10\">10<\/a><\/td><td>Resultados obtenidos en combinaci\u00f3n con un derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/section>\n<section class=\"sec\" id=\"faq\" aria-labelledby=\"h-faq\"><div class=\"wrap faq-grid\">\n  <h2 class=\"h2\" id=\"h-faq\">Preguntas frecuentes sobre p\u00e9ptidos<\/h2><div class=\"faq\"><details open><summary>\u00bfQu\u00e9 son los p\u00e9ptidos en cosm\u00e9tica?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Son cadenas cortas de amino\u00e1cidos, los componentes b\u00e1sicos de las prote\u00ednas. Se clasifican seg\u00fan su supuesto mecanismo de acci\u00f3n: p\u00e9ptidos se\u00f1al, transportadores, inhibidores de neurotransmisores e inhibidores de enzimas<a class=\"ref\" href=\"#src-1\">1<\/a>. En la etiqueta, cada p\u00e9ptido tiene su propio nombre INCI, por ejemplo PALMITOYL TRIPEPTIDE-38 o ACETYL HEXAPEPTIDE-8.<\/div><\/details><details><summary>\u00bfQu\u00e9 beneficios tienen los p\u00e9ptidos para la piel?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Los ensayos citados estudian arrugas y l\u00edneas de expresi\u00f3n menos visibles<a class=\"ref\" href=\"#src-3\">3<\/a><a class=\"ref\" href=\"#src-4\">4<\/a>, manchas pigmentarias m\u00e1s discretas en combinaci\u00f3n con un derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a> y una piel m\u00e1s uniforme<a class=\"ref\" href=\"#src-6\">6<\/a>. El nivel de evidencia sigue siendo modesto: un metaan\u00e1lisis de 19 ensayos concluye que el efecto sobre las arrugas es modesto y se debe sobre todo a los p\u00e9ptidos orales<a class=\"ref\" href=\"#src-2\">2<\/a>. Los resultados dependen del p\u00e9ptido, de la f\u00f3rmula y de la duraci\u00f3n.<\/div><\/details><details><summary>\u00bfQu\u00e9 p\u00e9ptido elegir: pentapeptide-4, p\u00e9ptido de cobre o hexapeptide-8?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Depende del beneficio que se quiera ofrecer con la gama. Palmitoyl pentapeptide-4 se ha estudiado para las arrugas y las l\u00edneas de expresi\u00f3n<a class=\"ref\" href=\"#src-3\">3<\/a>, acetyl hexapeptide-8 para las arrugas del contorno de ojos<a class=\"ref\" href=\"#src-4\">4<\/a>, tetrapeptide-30 para las manchas pigmentarias<a class=\"ref\" href=\"#src-5\">5<\/a> y el p\u00e9ptido de cobre para la firmeza, sobre todo en una revisi\u00f3n narrativa<a class=\"ref\" href=\"#src-7\">7<\/a>. La elecci\u00f3n se realiza con el formulador, seg\u00fan el objetivo y el presupuesto destinado al activo.<\/div><\/details><details><summary>\u00bfQu\u00e9 porcentaje de p\u00e9ptidos debe contener una crema o un s\u00e9rum?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Los p\u00e9ptidos se utilizan en dosis muy bajas: 3 ppm (0,0003 %) de palmitoyl pentapeptide-4<a class=\"ref\" href=\"#src-3\">3<\/a> y 5 ppm (0,0005 %) de palmitoyl tripeptide-38<a class=\"ref\" href=\"#src-6\">6<\/a> en los ensayos citados. El panel CIR fija el 0,005 % como l\u00edmite considerado seguro para acetyl hexapeptide-8<a class=\"ref\" href=\"#src-10\">10<\/a>. Por tanto, un \u00abalto contenido en p\u00e9ptidos\u00bb no garantiza la eficacia.<\/div><\/details><details><summary>\u00bfLos p\u00e9ptidos penetran en la piel?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Muy poco. En el caso de acetyl hexapeptide-8, el 0,22 % de la dosis alcanza el estrato c\u00f3rneo de la piel humana y no se detecta p\u00e9ptido en la dermis<a class=\"ref\" href=\"#src-8\">8<\/a>. Los lipop\u00e9ptidos se detectan en la superficie de las c\u00e9lulas del estrato c\u00f3rneo, no en su interior<a class=\"ref\" href=\"#src-9\">9<\/a>. Conviene conocer esta limitaci\u00f3n antes de prometer un efecto en profundidad.<\/div><\/details><details><summary>\u00bfCon qu\u00e9 se pueden combinar los p\u00e9ptidos?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">En nuestras f\u00f3rmulas, se combinan con mayor frecuencia con manteca de karit\u00e9, aceites de coco, almendras dulces y arg\u00e1n, y niacinamida. En los ensayos citados, tetrapeptide-30 se estudi\u00f3 con un derivado de vitamina C<a class=\"ref\" href=\"#src-5\">5<\/a> y palmitoyl tripeptide-38 con vitamina C y vitamina E<a class=\"ref\" href=\"#src-6\">6<\/a>. La compatibilidad de la f\u00f3rmula final se comprueba mediante pruebas de estabilidad en el laboratorio.<\/div><\/details><details><summary>\u00bfLos p\u00e9ptidos presentan riesgos?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">En el metaan\u00e1lisis de 19 ensayos, la tolerancia es buena, con pocos acontecimientos adversos<a class=\"ref\" href=\"#src-2\">2<\/a>. El panel CIR considera seguro acetyl hexapeptide-8 hasta el 0,005 %<a class=\"ref\" href=\"#src-10\">10<\/a>; no se ha encontrado una conclusi\u00f3n equivalente para los dem\u00e1s p\u00e9ptidos citados aqu\u00ed, que tampoco tienen restricciones en la UE<a class=\"ref\" href=\"#src-11\">11<\/a><a class=\"ref\" href=\"#src-12\">12<\/a><a class=\"ref\" href=\"#src-13\">13<\/a><a class=\"ref\" href=\"#src-14\">14<\/a><a class=\"ref\" href=\"#src-15\">15<\/a><a class=\"ref\" href=\"#src-16\">16<\/a>. Sigue siendo aconsejable realizar una prueba de tolerancia de la f\u00f3rmula final.<\/div><\/details><details><summary>\u00bfPueden fabricar un s\u00e9rum con p\u00e9ptidos para mi marca?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">S\u00ed. Nuestro laboratorio <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/certificaciones-iso-22716\/\">certificado seg\u00fan la norma ISO 22716<\/a> ofrece 6 f\u00f3rmulas con p\u00e9ptidos (s\u00e9rum, cremas y cuidados capilares) que puede personalizar, o una <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/laboratorio-formulacion-cosmetica\/\">f\u00f3rmula a medida<\/a>. La elecci\u00f3n y la dosificaci\u00f3n de los p\u00e9ptidos se definen con nuestros formuladores. Las muestras son gratuitas.<\/div><\/details><\/div><\/div><\/section>\n<section class=\"sec\" id=\"plus\" aria-labelledby=\"h-more\" style=\"padding-top:0\"><div class=\"wrap more-grid\">\n  <div><h2 class=\"h2\" id=\"h-more\">Lecturas complementarias<\/h2><div class=\"hubs\"><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\">Glosario de ingredientes<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/catalogo-cosmetica-marca-blanca\/serums-faciales-marca-blanca\/\">S\u00e9rums faciales en marca blanca<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/es\/laboratorio-formulacion-cosmetica\/\">Formulaci\u00f3n cosm\u00e9tica a medida<\/a><\/div><\/div>\n  <ul class=\"more-list\"><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/top-10-ingredientes-cosmeticos-tendencia-2026-activos-debe\/\"><span><strong>Los 10 ingredientes cosm\u00e9ticos de tendencia en 2026<\/strong><small>Los activos que puede incorporar a una gama de marca blanca<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/in-cosmetics-paris-2026-balance-feria-e-ingredientes-nueva\/\"><span><strong>in-cosmetics Paris 2026: tendencias en ingredientes<\/strong><small>Nuevos p\u00e9ptidos y activos presentados en la feria<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/es\/piel-menopausia-formular-gama-cuidados-conforme-2026\/\"><span><strong>Piel en la menopausia: formular una gama de cuidados conforme a la normativa<\/strong><small>Qu\u00e9 beneficios se pueden comunicar con activos cl\u00e1sicos, incluidos los p\u00e9ptidos<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><\/div><\/section>\n<section class=\"sec sources\" id=\"sources\" aria-labelledby=\"h-s\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-s\">Fuentes<\/h2><p class=\"lede\">Estudios revisados por pares y fuentes normativas oficiales, consultados el 3 de noviembre de 2026.<\/p>\n  <ol class=\"src\"><li id=\"src-1\"><span>Gorouhi F, Maibach HI. <em>Role of topical peptides in preventing or treating aged skin.<\/em> Int J Cosmet Sci. 2009;31(5):327-345. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1468-2494.2009.00490.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1468-2494.2009.00490.x<\/a><\/span><\/li><li id=\"src-2\"><span>Nukaly HY, Halawani IR, Irtaza HM, et al. <em>Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials.<\/em> Front Med (Lausanne). 2026;13:1618306. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.3389\/fmed.2026.1618306\" target=\"_blank\" rel=\"noopener\">doi:10.3389\/fmed.2026.1618306<\/a><\/span><\/li><li id=\"src-3\"><span>Robinson LR, Fitzgerald NC, Doughty DG, et al. <em>Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.<\/em> Int J Cosmet Sci. 2005;27(3):155-160. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1467-2494.2005.00261.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1467-2494.2005.00261.x<\/a><span class=\"tag\">Procter &amp; Gamble<\/span><\/span><\/li><li id=\"src-4\"><span>Wang Y, Wang M, Xiao S, et al. <em>The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.<\/em> Am J Clin Dermatol. 2013;14(2):147-153. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1007\/s40257-013-0009-9\" target=\"_blank\" rel=\"noopener\">doi:10.1007\/s40257-013-0009-9<\/a><\/span><\/li><li id=\"src-5\"><span>Marini A, Farwick M, Grether-Beck S, et al. <em>Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects.<\/em> Exp Dermatol. 2012;21(2):140-146. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01415.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1600-0625.2011.01415.x<\/a><span class=\"tag\">Evonik (coautor)<\/span><\/span><\/li><li id=\"src-6\"><span>Lintner K, Gerstein F, Solish N. <em>A serum containing vitamins C &amp; E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis and frequently repeated auto-perception.<\/em> J Cosmet Dermatol. 2020;19(12):3262-3269. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/jocd.13770\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/jocd.13770<\/a><span class=\"tag\">KAL&#x27;IDEES \/ Alumier Labs<\/span><\/span><\/li><li id=\"src-7\"><span>Pickart L, Vasquez-Soltero JM, Margolina A. <em>GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration.<\/em> Biomed Res Int. 2015;2015:648108. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1155\/2015\/648108\" target=\"_blank\" rel=\"noopener\">doi:10.1155\/2015\/648108<\/a><span class=\"tag\">Skin Biology<\/span><\/span><\/li><li id=\"src-8\"><span>Kraeling ME, Zhou W, Wang P, Ogunsola OA. <em>In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.<\/em> Cutan Ocul Toxicol. 2015;34(1):46-52. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.3109\/15569527.2014.894521\" target=\"_blank\" rel=\"noopener\">doi:10.3109\/15569527.2014.894521<\/a><\/span><\/li><li id=\"src-9\"><span>Trzaska AH, Kotowska AM, Starr NJ, et al. <em>Permeation behaviour of cosmetic actives into the human stratum corneum.<\/em> Int J Pharm. 2026;705:127447. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1016\/j.ijpharm.2026.127447\" target=\"_blank\" rel=\"noopener\">doi:10.1016\/j.ijpharm.2026.127447<\/a><span class=\"tag\">No7 Beauty Company<\/span><\/span><\/li><li id=\"src-10\"><span>Johnson W Jr, Bergfeld WF, Belsito DV, et al. <em>Safety assessment of acetyl hexapeptide-8 amide as used in cosmetics.<\/em> Int J Toxicol. 2025;44(2_suppl):54S-63S. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1177\/10915818251340391\" target=\"_blank\" rel=\"noopener\">doi:10.1177\/10915818251340391<\/a><\/span><\/li><li id=\"src-11\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha PALMITOYL TRIPEPTIDE-38<\/em> (CAS no indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/85966\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-12\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha PALMITOYL PENTAPEPTIDE-4<\/em> (CAS 214047-00-4 \/ 521091-64-5). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/56913\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-13\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha PALMITOYL TRIPEPTIDE-1<\/em> (CAS 147732-56-7). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/92513\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-14\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha COPPER TRIPEPTIDE-1<\/em> (CAS no indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/55687\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-15\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha ACETYL HEXAPEPTIDE-8<\/em> (CAS 616204-22-9). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/54135\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-16\"><span>Comisi\u00f3n Europea. <em>CosIng, ficha TETRAPEPTIDE-30<\/em> (CAS no indicado). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/88932\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><\/ol><\/div><\/section>\n\n<div class=\"fab\" id=\"fab\"><a class=\"btn\" href=\"#consultation\">Crear un producto con p\u00e9ptidos <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div><div class=\"scrim\" id=\"scrim\"><\/div><div class=\"pop\" id=\"pop\" role=\"dialog\" aria-modal=\"false\" aria-labelledby=\"pop-n\" hidden><div class=\"pop-n\" id=\"pop-n\"><\/div><div class=\"pop-body\" id=\"pop-body\"><\/div><div class=\"pop-foot\"><a class=\"txt-link\" id=\"pop-all\" href=\"#sources\">Todas las fuentes<\/a><button class=\"pop-x\" type=\"button\" id=\"pop-x\">Cerrar<\/button><\/div><\/div>\n<\/div>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@graph\": [{\"@type\": \"WebPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/peptidos\/#webpage\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/peptidos\/\", \"name\": \"P\u00e9ptidos cosm\u00e9ticos: tipos, estudios y usos\", \"inLanguage\": \"es-ES\", \"datePublished\": \"2026-11-03\", \"dateModified\": \"2026-11-03\", \"author\": {\"@type\": \"Person\", \"name\": \"Mohamed El Hjouji\", \"jobTitle\": \"Fundador y director ejecutivo\", \"worksFor\": {\"@type\": \"Organization\", \"name\": \"Carmel Cosmetics Labs\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/\"}}, \"about\": {\"@type\": \"Thing\", \"name\": \"P\u00e9ptidos cosm\u00e9ticos\", \"alternateName\": [\"P\u00e9ptidos\", \"P\u00e9ptidos cosmec\u00e9uticos\", \"Palmitoyl tripeptide-38\", \"Palmitoyl pentapeptide-4\", \"Acetyl hexapeptide-8\", \"Tetrapeptide-30\", \"Copper tripeptide-1\"]}, \"mainEntity\": {\"@id\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/peptidos\/#term\"}, \"isPartOf\": {\"@type\": \"CollectionPage\", \"name\": \"Glosario de ingredientes cosm\u00e9ticos\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\"}, \"relatedLink\": [\"https:\/\/carmelcosmeticslabs.com\/ingredients-cosmetiques-tendance-2026-guide-b2b-marque-blanche\/\", \"https:\/\/carmelcosmeticslabs.com\/in-cosmetics-paris-2026-tendances-ingredients-laboratoire-cosmetique\/\", \"https:\/\/carmelcosmeticslabs.com\/peau-menopause-formuler-gamme\/\"], \"citation\": [{\"@type\": \"ScholarlyArticle\", \"name\": \"Role of topical peptides in preventing or treating aged skin\", \"sameAs\": \"https:\/\/doi.org\/10.1111\/j.1468-2494.2009.00490.x\", \"datePublished\": \"2009\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials\", \"sameAs\": \"https:\/\/doi.org\/10.3389\/fmed.2026.1618306\", \"datePublished\": \"2026\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin\", \"sameAs\": \"https:\/\/doi.org\/10.1111\/j.1467-2494.2005.00261.x\", \"datePublished\": \"2005\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study\", \"sameAs\": \"https:\/\/doi.org\/10.1007\/s40257-013-0009-9\", \"datePublished\": \"2013\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects\", \"sameAs\": \"https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01415.x\", \"datePublished\": \"2012\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis and frequently repeated auto-perception\", \"sameAs\": \"https:\/\/doi.org\/10.1111\/jocd.13770\", \"datePublished\": \"2020\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration\", \"sameAs\": \"https:\/\/doi.org\/10.1155\/2015\/648108\", \"datePublished\": \"2015\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation\", \"sameAs\": \"https:\/\/doi.org\/10.3109\/15569527.2014.894521\", \"datePublished\": \"2015\"}, 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\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/55687\"}, {\"@type\": \"WebPage\", \"name\": \"CosIng - ACETYL HEXAPEPTIDE-8\", \"url\": \"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/54135\"}, {\"@type\": \"WebPage\", \"name\": \"CosIng - TETRAPEPTIDE-30\", \"url\": \"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/88932\"}]}, {\"@type\": \"DefinedTerm\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/peptidos\/#term\", \"name\": \"P\u00e9ptidos\", \"alternateName\": \"PALMITOYL TRIPEPTIDE-38\", \"description\": \"Cadenas cortas de amino\u00e1cidos utilizadas en cosm\u00e9tica como agentes acondicionadores de la piel, clasificadas seg\u00fan su supuesto mecanismo de acci\u00f3n: p\u00e9ptidos se\u00f1al, transportadores, inhibidores de neurotransmisores e inhibidores de enzimas.\", \"inDefinedTermSet\": {\"@type\": \"DefinedTermSet\", \"name\": \"Glosario de ingredientes cosm\u00e9ticos\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/es\/glosario-ingredientes-cosmeticos\/\"}}, {\"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 son los p\u00e9ptidos en cosm\u00e9tica?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Son cadenas cortas de amino\u00e1cidos, los componentes b\u00e1sicos de las prote\u00ednas. Se clasifican seg\u00fan su supuesto mecanismo de acci\u00f3n: p\u00e9ptidos se\u00f1al, transportadores, inhibidores de neurotransmisores e inhibidores de enzimas. En la etiqueta, cada p\u00e9ptido tiene su propio nombre INCI, por ejemplo PALMITOYL TRIPEPTIDE-38 o ACETYL HEXAPEPTIDE-8.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 beneficios tienen los p\u00e9ptidos para la piel?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Los ensayos citados estudian arrugas y l\u00edneas de expresi\u00f3n menos visibles, manchas pigmentarias m\u00e1s discretas en combinaci\u00f3n con un derivado de vitamina C y una piel m\u00e1s uniforme. El nivel de evidencia sigue siendo modesto: un metaan\u00e1lisis de 19 ensayos concluye que el efecto sobre las arrugas es modesto y se debe sobre todo a los p\u00e9ptidos orales. Los resultados dependen del p\u00e9ptido, de la f\u00f3rmula y de la duraci\u00f3n.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 p\u00e9ptido elegir: pentapeptide-4, p\u00e9ptido de cobre o hexapeptide-8?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Depende del beneficio que se quiera ofrecer con la gama. Palmitoyl pentapeptide-4 se ha estudiado para las arrugas y las l\u00edneas de expresi\u00f3n, acetyl hexapeptide-8 para las arrugas del contorno de ojos, tetrapeptide-30 para las manchas pigmentarias y el p\u00e9ptido de cobre para la firmeza, sobre todo en una revisi\u00f3n narrativa. La elecci\u00f3n se realiza con el formulador, seg\u00fan el objetivo y el presupuesto destinado al activo.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfQu\u00e9 porcentaje de p\u00e9ptidos debe contener una crema o un s\u00e9rum?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Los p\u00e9ptidos se utilizan en dosis muy bajas: 3 ppm (0,0003 %) de palmitoyl pentapeptide-4 y 5 ppm (0,0005 %) de palmitoyl tripeptide-38 en los ensayos citados. El panel CIR fija el 0,005 % como l\u00edmite considerado seguro para acetyl hexapeptide-8. Por tanto, un \u00abalto contenido en p\u00e9ptidos\u00bb no garantiza la eficacia.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfLos p\u00e9ptidos penetran en la piel?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Muy poco. En el caso de acetyl hexapeptide-8, el 0,22 % de la dosis alcanza el estrato c\u00f3rneo de la piel humana y no se detecta p\u00e9ptido en la dermis. Los lipop\u00e9ptidos se detectan en la superficie de las c\u00e9lulas del estrato c\u00f3rneo, no en su interior. Conviene conocer esta limitaci\u00f3n antes de prometer un efecto en profundidad.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfCon qu\u00e9 se pueden combinar los p\u00e9ptidos?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"En nuestras f\u00f3rmulas, se combinan con mayor frecuencia con manteca de karit\u00e9, aceites de coco, almendras dulces y arg\u00e1n, y niacinamida. En los ensayos citados, tetrapeptide-30 se estudi\u00f3 con un derivado de vitamina C y palmitoyl tripeptide-38 con vitamina C y vitamina E. La compatibilidad de la f\u00f3rmula final se comprueba mediante pruebas de estabilidad en el laboratorio.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfLos p\u00e9ptidos presentan riesgos?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"En el metaan\u00e1lisis de 19 ensayos, la tolerancia es buena, con pocos acontecimientos adversos. El panel CIR considera seguro acetyl hexapeptide-8 hasta el 0,005 %; no se ha encontrado una conclusi\u00f3n equivalente para los dem\u00e1s p\u00e9ptidos citados aqu\u00ed, que tampoco tienen restricciones en la UE. Sigue siendo aconsejable realizar una prueba de tolerancia de la f\u00f3rmula final.\"}}, {\"@type\": \"Question\", \"name\": \"\u00bfPueden fabricar un s\u00e9rum con p\u00e9ptidos para mi marca?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"S\u00ed. Nuestro laboratorio certificado seg\u00fan la norma ISO 22716 ofrece 6 f\u00f3rmulas con p\u00e9ptidos (s\u00e9rum, cremas y cuidados capilares) que puede personalizar, o una f\u00f3rmula a medida. La elecci\u00f3n y la dosificaci\u00f3n de los p\u00e9ptidos se definen con nuestros formuladores. 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wpforms-field-required choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-large\" data-search-enabled=\"\" name=\"wpforms[fields][4]\" required=\"required\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'>Elija su medio de contacto preferido<\/option><option value=\"WhatsApp\"  class=\"choice-1 depth-1\"  >WhatsApp<\/option><option value=\"Correo electr\u00f3nico\"  class=\"choice-2 depth-1\"  >Correo electr\u00f3nico<\/option><option value=\"Llamada telef\u00f3nica\"  class=\"choice-3 depth-1\"  >Llamada telef\u00f3nica<\/option><\/select><\/div><div id=\"wpforms-51144-field_2-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-type=\"textarea\" data-field-id=\"2\"><label class=\"wpforms-field-label\" for=\"wpforms-51144-field_2\">Describa brevemente su proyecto: <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><textarea id=\"wpforms-51144-field_2\" class=\"wpforms-field-medium 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