{"id":56218,"date":"2026-10-31T20:20:23","date_gmt":"2026-10-31T20:20:23","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?p=56218"},"modified":"2026-11-04T07:47:10","modified_gmt":"2026-11-04T07:47:10","slug":"tranexamic-acid-skincare","status":"publish","type":"post","link":"https:\/\/carmelcosmeticslabs.com\/en\/tranexamic-acid-skincare\/","title":{"rendered":"Tranexamic acid skincare: INCI, dosage and EU claims"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Tranexamic acid skincare uses a synthetic lysine derivative in products that aim for a more even-looking skin tone and a softer look of dark spots.<\/strong> Listed under the INCI name <em>Tranexamic Acid<\/em>, it is water-soluble, mostly formulated in serums, and often dosed at 2 to 5% in published topical trials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tranexamic acid in skincare: key takeaways<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Definition<\/strong>: a synthetic molecule close to lysine, first known as an antifibrinolytic drug, and also registered as a cosmetic ingredient in the European CosIng database.<\/li>\n<li><strong>Cosmetic role<\/strong>: helps even the look of skin tone and soften the look of dark spots, with no therapeutic promise.<\/li>\n<li><strong>Studied dosages<\/strong>: 2 to 5% in most topical trials listed by recent reviews.<\/li>\n<li><strong>Point of caution<\/strong>: published trials mostly belong to dermatology (oral route, injections, medical protocols) and do not translate into a cosmetic claim.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What is tranexamic acid?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tranexamic acid is a synthetic analog of lysine, an amino acid. A review published in 2020 in <em>Clinical and Molecular Allergy<\/em> describes it as <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7473809\/\" target=\"_blank\" rel=\"noopener\">&#8220;a synthetic lysine analog well known as an antifibrinolytic agent&#8221;<\/a>. In medicine, it is used to limit certain types of bleeding. This pharmaceutical origin is why the question of claims must be handled with rigor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">An antifibrinolytic agent is a substance that slows the breakdown of fibrin, the protein that stabilizes a blood clot. This role has nothing cosmetic about it: what interests formulators is a mechanism linked to plasmin. Plasmin is an enzyme derived from plasminogen, known for dissolving clots, which also acts in the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Driven by demand for skin tone care, the molecule is found in cosmetic serums and day creams, as our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/trending-cosmetic-ingredients-2026\/\">selection of trending ingredients for 2026<\/a> shows.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is the INCI name and regulatory status of tranexamic acid?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The INCI name of tranexamic acid is <em>Tranexamic Acid<\/em> (CAS 1197-18-8). The European <a href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/80291\" target=\"_blank\" rel=\"noopener\">CosIng<\/a> database lists it (record 80291) with the functions &#8220;astringent&#8221; and &#8220;skin conditioning&#8221;, with no entry in the annexes of banned or restricted substances of Regulation (EC) no. 1223\/2009 and no maximum concentration set. To find the INCI name of other raw materials, see our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">ingredient glossary<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CosIng is the European Commission database that lists cosmetic ingredients and their restrictions; it is informative, and only the safety assessment of the finished product is authoritative.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the regulatory side, the key point is the <strong>boundary between cosmetic and medicine<\/strong>. <a href=\"https:\/\/eur-lex.europa.eu\/legal-content\/FR\/TXT\/?uri=CELEX:32009R1223\" target=\"_blank\" rel=\"noopener\">Regulation (EC) no. 1223\/2009<\/a> defines a cosmetic product by its purpose: cleaning, perfuming, changing the appearance, protecting or keeping the skin in good condition. A product that claims an action on a skin condition falls outside this framework: a tranexamic acid serum can therefore claim a more even-looking skin tone, but not an action on a pigmentation disorder.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In Morocco, placing a cosmetic on the market goes through AMMPS: the details are in our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-product-registration-morocco\/\">AMMPS registration guide<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How does tranexamic acid act on the look of dark spots?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">According to published hypotheses, tranexamic acid would limit the activation of plasmin in the epidermis, a signal that takes part in melanin production. A literature review published in 2026 in the <em>Journal of Cosmetic Dermatology<\/em> states that it <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12848551\/\" target=\"_blank\" rel=\"noopener\">reduces the binding of plasminogen to keratinocytes and limits UV-induced plasmin activation<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the skin, plasmin stimulates the release of mediators that activate melanocytes, the pigment-producing cells. According to this hypothesis, the molecule would act upstream of pigmentation, which sets it apart from actives that work on tyrosinase or on exfoliation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The mechanism is a research topic, not something to claim: a cosmetic claim is limited to appearance (&#8220;evens the look of skin tone&#8221;, &#8220;softens the look of dark spots&#8221;). Any therapeutic verb must be avoided, as must any mention of a skin disease on the label or product sheet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What do studies say about topical tranexamic acid?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Studies on this active applied to the skin mostly come from dermatological research, and some concern the oral route or injections, which are strictly medical uses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A few reference points from published reviews:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A 2026 review (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12848551\/\" target=\"_blank\" rel=\"noopener\">AlJabr et al.<\/a>) reports a 12-week double-blind randomized trial in <strong>60 women<\/strong>, which compared a cream with 5% tranexamic acid with a medical-use reference cream (2% hydroquinone): both groups improved in a comparable way. This is a dermatological protocol, not cosmetic proof.<\/li>\n<li>A 2022 systematic review (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9805721\/\" target=\"_blank\" rel=\"noopener\">Alsharif et al.<\/a>) pools <strong>9 studies and 196 patients<\/strong>, of which only 3 concern topical use. It notably cites the Desai study: a serum combining 3% tranexamic acid, 1% <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/kojic-acid\/\">kojic acid<\/a> and 5% <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/niacinamide\/\">niacinamide<\/a>, tested in 55 patients over a 12-week period, in a single-center study without a control group, on post-inflammatory hyperpigmentation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This last formula is not a model to copy in Europe: kojic acid is now restricted. <a href=\"https:\/\/eur-lex.europa.eu\/legal-content\/FR\/TXT\/?uri=CELEX:32024R0996\" target=\"_blank\" rel=\"noopener\">Regulation (EU) 2024\/996<\/a> added it to Annex III of Regulation (EC) no. 1223\/2009 (entry 375, mentioned in CosIng), with a maximum concentration of 1% and use limited to face and hand products.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These figures describe supervised clinical protocols: a brand cannot reuse them as proof of its own product&#8217;s efficacy. A claim must rest on evidence suited to the finished product, as <a href=\"https:\/\/eur-lex.europa.eu\/legal-content\/FR\/TXT\/?uri=CELEX:32013R0655\" target=\"_blank\" rel=\"noopener\">Regulation (EU) no. 655\/2013<\/a> on the common criteria for claims requires. To go further, read our article on <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/how-are-cosmetic-claims-regulated-in-the-eu\/\">cosmetic claims in the EU<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What concentration of tranexamic acid in a serum?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In a tranexamic acid serum, the active is most often dosed between 2 and 5%, the range that comes up in the topical trials listed by recent literature. The final dosage depends on the format, the other actives and the conclusions of the safety assessor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A higher concentration is not necessarily the right choice. It increases raw material cost and can complicate stability or tolerance, with no benefit established by the sources cited.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Format<\/th><th>Benefit for tranexamic acid<\/th><th>Point of attention<\/th><\/tr><\/thead><tbody><tr><td>Aqueous serum or gel<\/td><td>Natural format for a water-soluble active, light texture, the most concentrated dosage in the range<\/td><td>Choose gelling agents compatible with the electrolytes and pH of the formula<\/td><\/tr><tr><td>Cream or emulsion<\/td><td>Combines the active with moisturizing agents in a daily care product<\/td><td>Check emulsion stability with the active in the water phase<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Common formats for a tranexamic acid skincare product<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Tranexamic acid and niacinamide: which combinations to favor?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tranexamic acid pairs well with niacinamide, <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/vitamin-c\/\">vitamin C<\/a> derivatives and azelaic acid, which target other steps of skin tone radiance. The combination with niacinamide is the most common in the formulas studied.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Combination<\/th><th>Formulation logic<\/th><th>Constraint to anticipate<\/th><\/tr><\/thead><tbody><tr><td>Tranexamic acid + niacinamide<\/td><td>Two water-soluble actives, easy to bring together in the same water phase<\/td><td>Monitor color and odor stability during testing<\/td><\/tr><tr><td>With vitamin C<\/td><td>Combines an antioxidant radiance active and an evenness active<\/td><td>Pure ascorbic acid requires a low pH and oxidizes; a more stable derivative simplifies the formula<\/td><\/tr><tr><td>With azelaic acid<\/td><td>Two complementary approaches to an even-looking skin tone<\/td><td>Solubility of azelaic acid and tolerance to monitor<\/td><\/tr><tr><td>With UV filters<\/td><td>UV rays keep the look of dark spots going: sun protection is the foundation of the routine<\/td><td>A product with SPF falls under a different level of testing<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Common combinations with tranexamic acid in cosmetics<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A short formula, with two or three well-dosed actives, stabilizes more easily and is easier to justify to the safety assessor. The same reasoning applies to other recent actives, such as <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/pdrn-skincare\/\">PDRN in cosmetics<\/a> or <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/exosome-skincare\/\">exosomes<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How do you recognize a tranexamic acid serum?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To recognize a tranexamic acid serum, look for <em>Tranexamic Acid<\/em> in the ingredient list printed on the packaging. A few pointers for reading the label:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ingredients are listed in descending order of concentration: its position gives an indication, not a precise dosage.<\/li>\n<li>The percentage of the active is not mandatory on the label; a brand may display it without being required to.<\/li>\n<li>Daily sun protection remains essential.<\/li>\n<li>A spot that persists, changes appearance or comes with a skin condition calls for medical advice, not a cosmetic.<\/li>\n<li>Tranexamic acid in tablets is a medicine, not a cosmetic.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How do you formulate a stable tranexamic acid serum?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To formulate a stable serum, incorporate the molecule in the water phase, set a pH compatible with all ingredients, then validate the whole with stability and packaging compatibility tests. The pH is the measure of the formula&#8217;s acidity; it determines its stability and tolerance.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Write the brief<\/strong>: target audience, texture, desired claims, positioning and selling markets (EU, Morocco, export).<\/li>\n<li><strong>Choose the dosage and combinations<\/strong> based on the literature and on the regulatory status of each ingredient.<\/li>\n<li><strong>Set the pH of the formula<\/strong> according to the most demanding active (for example a vitamin C) and skin tolerance.<\/li>\n<li><strong>Select the preservative system<\/strong> and verify its efficacy with a challenge test.<\/li>\n<li><strong>Run stability tests<\/strong> at different temperatures, and compatibility tests with the chosen bottle, dropper or pump.<\/li>\n<li><strong>Build the file<\/strong>: safety assessment, claim evidence, labeling and notification in the target markets.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Stability testing and quality control are described in our article on <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/how-to-test-the-quality-of-your-cosmetic-products\/\">quality tests for a cosmetic<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The manufacturer&#8217;s view<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Carmel Cosmetics Labs is a cosmetics laboratory and manufacturer based in Agadir, certified ISO 22716 (cosmetic good manufacturing practice) and ISO 9001. It has supported 500+ brands in 35+ countries, in white label, private label and contract manufacturing, with formulas designed for Regulation (EC) no. 1223\/2009 and, for US export, FDA requirements. On an &#8220;even skin tone&#8221; serum, a few habits make the difference:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Think claims from the brief.<\/strong> A cosmetic promise set from the start avoids rewriting the label and visuals at the end of the project.<\/li>\n<li><strong>Do not copy a competitor&#8217;s percentage.<\/strong> Displaying &#8220;5%&#8221; only makes sense if the whole formula is stable, tolerated and justifiable.<\/li>\n<li><strong>Check every associated ingredient.<\/strong> A secondary active can be restricted, like kojic acid in the EU: status is checked ingredient by ingredient, market by market.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">To frame these points before development, a <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-product-specification-guide\/\">cosmetic specification brief<\/a> remains the most useful tool, and our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-product-information-file-pif\/\">regulatory support<\/a> helps prepare the file. Our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/dermocosmetics-manufacturer\/\">dermocosmetics laboratory<\/a> can develop an <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetics-private-label-service\/\">exclusive private label formula<\/a>, or start from an existing base from our <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/\">catalog of customizable products<\/a>, in <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/white-label-cosmetics-service\/\">white label with an accessible MOQ<\/a>. For a first project, our guide on <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/how-to-start-a-cosmetics-brand\/\">how to create a cosmetic brand<\/a> details the steps.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently asked questions<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">How do you read the INCI list of a serum?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The INCI list gives ingredients under their international name, from most to least concentrated. Under Article 19 of Regulation (EC) no. 1223\/2009, however, ingredients present at less than 1% may be listed in any order after the others. Nanomaterials are flagged with the word &#8220;nano&#8221; in brackets.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can tranexamic acid be combined with vitamin C?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The combination is common in skin tone radiance products, but the reviews cited in this article report no trial evaluating this combination in topical application. The difficulty is mostly technical: pure ascorbic acid requires a low pH and oxidizes easily, whereas some vitamin C derivatives are more stable. Compatibility is validated through stability tests on the complete formula.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can you use a tranexamic acid serum every day?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In the topical trials listed by the 2026 review, the active is most often applied twice a day, with occasional mild irritation. For a cosmetic product, the frequency of use is set by the manufacturer based on tolerance tests and the safety assessment. Daily sun protection remains recommended as a complement.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is tranexamic acid suitable for sensitive skin?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Literature reviews report adverse effects in topical application that are mostly mild: irritation, dryness or tingling. The tolerance of a product depends, however, on the complete formula (pH, fragrance, other actives, preservatives). For a range intended for sensitive skin, tolerance tests under dermatological control are recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion: an active to formulate with rigor<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tranexamic acid is a water-soluble active, heavily studied in dermatology, whose tolerance in a finished product is judged on the complete formula. Its studied dosages range from 2 to 5%, in a frame that is often medical: the success of a cosmetic product depends as much on formula stability as on the accuracy of its claims.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Preparing a tranexamic acid serum or range? <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/request-a-quote\/\">Book a free consultation with our laboratory<\/a> or <a href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-formulation-lab\/\">discover our approach to formulation<\/a>.<\/p>\n\n\n\n\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/en\/tranexamic-acid-skincare\/#faq\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"How do you read the INCI list of a serum?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The INCI list gives ingredients under their international name, from most to least concentrated. 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Learn its INCI name, studied dosages, serum formats, ingredient pairings and the claims a brand can compliantly make in the EU.<\/p>\n","protected":false},"author":3,"featured_media":53896,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[669],"tags":[820,724,728,722,821],"class_list":["post-56218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ingredients-formulations-en","tag-acide-tranexamique","tag-actifs-skincare","tag-formulation-cosmetique","tag-ingredients-cosmetiques","tag-niacinamide"],"acf":[],"_links":{"self":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/posts\/56218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/comments?post=56218"}],"version-history":[{"count":0,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/posts\/56218\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/media\/53896"}],"wp:attachment":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/media?parent=56218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/categories?post=56218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/tags?post=56218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}