{"id":55680,"date":"2026-11-03T10:55:01","date_gmt":"2026-11-03T10:55:01","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?page_id=55680"},"modified":"2026-11-05T12:39:51","modified_gmt":"2026-11-05T12:39:51","slug":"zinc-pca","status":"publish","type":"page","link":"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/zinc-pca\/","title":{"rendered":"Zinc PCA"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"55680\" class=\"elementor elementor-55680 elementor-55529 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-d5e2b4f e-flex e-con-full e-con e-parent\" data-id=\"d5e2b4f\" data-element_type=\"container\" data-e-type=\"container\" id=\"ing-zinc-pca\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e46dd25 elementor-widget elementor-widget-html\" data-id=\"e46dd25\" 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.pins-list{display:block}.ig .track .pin{display:none}}\n<\/style>\n<div class=\"ig\" data-ing=\"zinc-pca\" lang=\"en\" data-copy=\"Copy\" data-copied=\"Copied\">\n<nav class=\"crumbs wrap\" aria-label=\"Breadcrumb\"><ol>\n  <li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/\">Home<\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">Ingredient glossary<\/a><\/li><li aria-current=\"page\">Zinc PCA<\/li><\/ol><\/nav>\n<header class=\"wrap hero\" id=\"top\">\n  <div class=\"hero-copy\">\n    <h1 class=\"h1-long\">Zinc PCA (zinc pidolate)<\/h1>\n    <p class=\"brief\">Zinc PCA is the zinc salt of pyrrolidone carboxylic acid (PCA), a natural component of the stratum corneum<a class=\"ref\" href=\"#src-5\">5<\/a>. It has long been used in cosmetics for its astringent and antimicrobial properties<a class=\"ref\" href=\"#src-3\">3<\/a>. Published evidence comes from the laboratory: no cosmetic sebum trial was retained. Limit: 1% as zinc<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p>\n    <div class=\"byline\"><span class=\"avatar\" aria-hidden=\"true\">ME<\/span>\n      <span><strong>Mohamed El Hjouji<\/strong>Founder and CEO \u00b7 Updated <time datetime=\"2026-11-03\">November 3, 2026<\/time> \u00b7 Reading time 7 min<\/span><\/div>\n    <div class=\"actions\">\n      <a class=\"btn\" href=\"#consultation\">Create a zinc PCA product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a>\n      <a class=\"btn-ghost\" href=\"#recherche\">Read the studies<\/a>\n    <\/div>\n  <\/div>\n  <figure class=\"hero-photo\"><img fetchpriority=\"high\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel.webp\" srcset=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel-300x224.webp 300w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel-441x329.webp 441w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel-768x574.webp 768w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel-990x740.webp 990w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel-1024x765.webp 1024w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel.webp 1400w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/zinc-pca-ingredient-cosmetique-carmel.webp 1400w\" sizes=\"(max-width:900px) 92vw, 46vw\" width=\"1400\" height=\"1046\" alt=\"White zinc PCA powder in macro view on a sage green ceramic surface, with a drop on a glass slide\" fetchpriority=\"high\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><\/figure>\n<\/header>\n<div class=\"bar\" id=\"bar\"><div class=\"wrap bar-in\">\n  <nav aria-label=\"On this page\"><ul><li><a href=\"#identite\">Identity<\/a><\/li><li><a href=\"#recherche\">Research<\/a><\/li><li><a href=\"#produits\">Products<\/a><\/li><li><a href=\"#comparatif\">Comparison<\/a><\/li><li><a href=\"#faq\">Questions<\/a><\/li><li><a href=\"#plus\">Reading<\/a><\/li><li><a href=\"#sources\">Sources<\/a><\/li><\/ul><\/nav>\n  <a class=\"btn sm\" href=\"#consultation\" tabindex=\"-1\">Create my product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div>\n  <span class=\"bar-prog\" id=\"prog\" aria-hidden=\"true\"><\/span><\/div>\n<section class=\"sec\" id=\"identite\" aria-labelledby=\"h-id\"><div class=\"wrap id-grid\">\n  <div><h2 class=\"h2\" id=\"h-id\">Zinc PCA at a glance<\/h2>\n  <p class=\"lede\">Entry from our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">cosmetic ingredient glossary<\/a>. Regulatory data from the European Commission's CosIng database<a class=\"ref\" href=\"#src-1\">1<\/a> and Regulation (EC) 1223\/2009<a class=\"ref\" href=\"#src-2\">2<\/a>. Copy the identifiers in one click for your files.<\/p><\/div>\n  <dl class=\"spec\"><div><dt>INCI name<\/dt><dd><span class=\"\">ZINC PCA<\/span><button class=\"copy\" type=\"button\" data-copy=\"ZINC PCA\" aria-label=\"Copy: INCI name\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><\/dd><\/div><div><dt>Other names<\/dt><dd>Zinc pidolate<small>CosIng chemical name: zinc salt of 5-oxoproline<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>CAS number<\/dt><dd><span class=\"num\">68107-75-5 \/ 15454-75-8<\/span><button class=\"copy\" type=\"button\" data-copy=\"68107-75-5 \/ 15454-75-8\" aria-label=\"Copy: CAS number\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><small>CosIng links two numbers to this entry<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>EC number<\/dt><dd><span class=\"num\">268-475-9 \/ 239-473-5<\/span><button class=\"copy\" type=\"button\" data-copy=\"268-475-9 \/ 239-473-5\" aria-label=\"Copy: EC number\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><\/dd><\/div><div><dt>CosIng functions<\/dt><dd>Humectant, skin conditioning<small>\"Humectant\" and \"skin conditioning\" in the European nomenclature<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>Appearance<\/dt><dd>White powder<small>Soluble in water, formulated in the aqueous phase<\/small><\/dd><\/div><div><dt>EU status<\/dt><dd>Annex III, entry 24: 1% as zinc<small>CosIng links zinc PCA to entry 24, which limits water-soluble zinc salts to 1% (as zinc)<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Allergen to declare<\/dt><dd>No<small>Absent from the fragrance allergen list of Regulation (EU) 2023\/1545<\/small><\/dd><\/div><div><dt>Safety<\/dt><dd>Zinc salts judged safe if non-irritating<small>CIR panel 2024 on 27 zinc salts; zinc PCA is not named in the abstract<a class=\"ref\" href=\"#src-7\">7<\/a><\/small><\/dd><\/div><\/dl><\/div><\/section>\n<section class=\"sec research\" id=\"recherche\" aria-labelledby=\"h-r\"><div class=\"wrap\">\n  <div class=\"r-head\"><div><h2 class=\"h2\" id=\"h-r\">What the research says<\/h2>\n  <p class=\"lede\">Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.<\/p><\/div><\/div>\n  <div class=\"r-tools\"><div class=\"seg\" role=\"group\" aria-label=\"Filter by area\" id=\"rfilter\"><button type=\"button\" aria-pressed=\"true\" data-d=\"all\">All <span>6<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"visage\">Face <span>4<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"derm\">Safety <span>2<\/span><\/button><\/div><div class=\"legend\" aria-label=\"Levels of evidence\"><span class=\"lvl\"><i class=\"dot c\"><\/i>Clinical trial<\/span><span class=\"lvl\"><i class=\"dot r\"><\/i>Review or consensus<\/span><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><\/div>\n  <div class=\"domain\" data-d=\"visage\"><h3>Facial skin<span>Skincare<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>PCA is part of the natural moisturizing factor<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Observational study<\/span><\/div><div class=\"meta\"><span>21 volunteers<\/span><span>11 carriers of a filaggrin mutation, 10 non-carriers<\/span><span>Tape stripping sampling<\/span><\/div><p>PCA measured in the stratum corneum is 1.64 mmol\/g of protein in non-carriers, 0.50 in carriers of one mutation and 0.18 in homozygotes<a class=\"ref\" href=\"#src-5\">5<\/a>. The natural moisturizing factor is a mixture of small water-soluble molecules derived from filaggrin<a class=\"ref\" href=\"#src-6\">6<\/a>. This says nothing about the effect of zinc PCA applied to skin.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Less collagen-degrading enzyme under UVA, in culture<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><div class=\"meta\"><span>Human dermal fibroblasts<\/span><span>UVA<\/span><\/div><p>Zinc PCA reduces AP-1 activation and the production of metalloproteinase-1, an enzyme that degrades collagen. It also increases the vitamin C transporter SVCT2 and type I collagen synthesis. A cell culture result, produced by an industry player: it does not predict the effect of a cream<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Zinc absorption in human skin, depending on the salt and the formula<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><div class=\"meta\"><span>Human skin in vitro<\/span><span>72 h<\/span><span>5 formulas: 3 emulsions, 2 ointments<\/span><\/div><p>Zinc from a zinc PCA emulsion is absorbed at 1.60% of the applied dose, against 0.36% for a zinc oxide ointment and 0.34% for a zinc sulfate ointment. All formulas increase epidermal zinc. The salt and the formula are not separated in this comparison<a class=\"ref\" href=\"#src-4\">4<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Sebum and shine: no cosmetic trial retained<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Gap in the literature<\/span><\/div><div class=\"meta\"><span>PubMed search, November 2026<\/span><\/div><p>We found no controlled cosmetic trial of zinc PCA on sebum or skin shine. The use of zinc PCA for oily skin therefore rests on tradition and indirect data, not on published evidence.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"derm\"><h3>Safety and regulation<span>Regulation<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Zinc salts: safe in current uses if non-irritating<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Review<\/span><\/div><div class=\"meta\"><span>CIR panel 2024<\/span><span>27 zinc salts<\/span><\/div><p>The panel concludes that 27 inorganic and organometallic zinc salts are safe in current uses and concentrations, provided they are formulated to be non-irritating. The abstract does not name zinc PCA: exact coverage must be checked in the report<a class=\"ref\" href=\"#src-7\">7<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Cosmetic zinc adds to dietary intake<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>European committee opinion<\/span><\/div><div class=\"meta\"><span>SCCS 2018<\/span><span>Toothpaste 1%, mouthwash 0.1%<\/span><\/div><p>For oral hygiene products, the committee estimates intake at 10 to 35% of the upper limit for zinc, depending on age. It notes that any additional source, cosmetics included, may exceed this limit in children, without being able to set the share of cosmetics<a class=\"ref\" href=\"#src-8\">8<\/a>.<\/p><\/article><\/div><\/div>\n  <p class=\"frame\">This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. For zinc PCA, published data are scarce and mostly from the laboratory. The clinical trials found combine zinc PCA with other actives in products with a medical purpose: they fall outside the scope of this page and are not included. One cited study has an industry affiliation; this is noted in the sources.<\/p><\/div><\/section>\n\n<section class=\"sec products\" id=\"produits\" aria-labelledby=\"h-p\"><div class=\"wrap\">\n  <div class=\"p-head\"><div><h2 class=\"h2\" id=\"h-p\">Which products use zinc PCA?<\/h2>\n  <p class=\"lede\">Our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/\">white label catalog<\/a> includes 1 formula with zinc PCA, always as a supporting ingredient. Every category can be customized (formula, fragrance, packaging).<\/p><\/div>\n  <\/div>\n  <div class=\"p-cols\" style=\"--pc:1\"><div class=\"p-col on\" id=\"pc-corps\" role=\"tabpanel\"><h3><span class=\"count num\">1<\/span>Body<\/h3><p>Supporting active in a refreshing scalp spray from the men&#x27;s line.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-mens-grooming\/\"><span>Men&#x27;s grooming<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><\/div><\/div>\n  <div class=\"pairs\"><p>In our formulas, it is most often paired with<\/p><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/hyaluronic-acid\/\">Hyaluronic acid <span class=\"num\">1<\/span><\/a><span class=\"chip\">Sage extract <span class=\"num\">1<\/span><\/span><span class=\"chip\">Peppermint essential oil <span class=\"num\">1<\/span><\/span><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/niacinamide\/\">Niacinamide <span class=\"num\">1<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/panthenol\/\">Panthenol <span class=\"num\">1<\/span><\/a><\/div>\n  <\/div><\/section>\n<section class=\"sec\" id=\"comparatif\" aria-labelledby=\"h-cmp\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-cmp\">Zinc PCA, niacinamide, kaolin or salicylic acid?<\/h2><p class=\"lede\">Four actives often chosen for oily skin. They do not exclude each other and are combined in several of our formulas.<\/p>\n  <div class=\"seg c-pick\" role=\"group\" aria-label=\"Compare with\" id=\"cpick\"><button type=\"button\" aria-pressed=\"true\" data-c=\"3\">Niacinamide<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"4\">Kaolin<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"5\">Salicylic acid<\/button><\/div>\n  <div class=\"tbl-wrap\"><table class=\"cmp\" id=\"cmp\" data-c=\"3\"><colgroup><col><col class=\"me\"><col><col><col><\/colgroup>\n  <thead><tr><td><\/td><th scope=\"col\">Zinc PCA<\/th><th scope=\"col\">Niacinamide<\/th><th scope=\"col\">Kaolin<\/th><th scope=\"col\">Salicylic acid<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Family<\/th><td>Zinc salt of PCA<a class=\"ref\" href=\"#src-1\">1<\/a><\/td><td>Vitamin B3, see the niacinamide entry<\/td><td>Clay, see the kaolin entry<\/td><td>BHA (common name), see the entry<\/td><\/tr><tr><th scope=\"row\">Evidence on sebum<\/th><td>No cosmetic trial retained<\/td><td>Clinical trials at 2%, see the niacinamide entry<\/td><td>See the kaolin entry<\/td><td>See the salicylic acid entry<\/td><\/tr><tr><th scope=\"row\">EU regulation<\/th><td>Annex III, entry 24: 1% as zinc<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>No restriction<\/td><td>See the kaolin entry<\/td><td>Restricted depending on the product, see the entry<\/td><\/tr><tr><th scope=\"row\">Watch point<\/th><td>Zinc adds to dietary intake, mainly in children<a class=\"ref\" href=\"#src-8\">8<\/a><\/td><td>See the niacinamide entry<\/td><td>See the kaolin entry<\/td><td>Sun protection recommended<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/section>\n<section class=\"sec\" id=\"faq\" aria-labelledby=\"h-faq\"><div class=\"wrap faq-grid\">\n  <h2 class=\"h2\" id=\"h-faq\">Frequently asked questions about zinc PCA<\/h2><div class=\"faq\"><details open><summary>What is zinc PCA?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">It is the zinc salt of pyrrolidone carboxylic acid (PCA), also called zinc pidolate. PCA is a natural component of the stratum corneum<a class=\"ref\" href=\"#src-5\">5<\/a>. In cosmetics, zinc PCA has long been used for its astringent and antimicrobial properties<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/div><\/details><details><summary>Is zinc PCA effective for oily skin?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">It is its most common use, but no controlled cosmetic trial on sebum was retained. Published data are from the laboratory: effect on fibroblasts under UVA<a class=\"ref\" href=\"#src-3\">3<\/a>, absorption into skin in vitro<a class=\"ref\" href=\"#src-4\">4<\/a>. In a formula, it is usually combined with better-documented actives, such as niacinamide.<\/div><\/details><details><summary>Is zinc PCA useful for the scalp or hair?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">No cosmetic study on this point was retained. Our catalog uses it as a supporting active in a refreshing scalp spray from the men's line, combined with other actives. This use is not backed by published evidence specific to zinc PCA.<\/div><\/details><details><summary>What percentage of zinc PCA should you use?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">No cited cosmetic study gives a concentration. The regulatory reference is entry 24 of Annex III: 1% maximum, expressed as zinc<a class=\"ref\" href=\"#src-1\">1<\/a><a class=\"ref\" href=\"#src-2\">2<\/a>. Since zinc PCA also contains PCA, the zinc content of the raw material is checked in its specification. The dose is set with the formulator.<\/div><\/details><details><summary>What is the difference between zinc PCA and zinc oxide?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">They are two different salts. In an in vitro comparison on human skin, zinc from a zinc PCA emulsion is absorbed at 1.60% of the dose, against 0.36% for a zinc oxide ointment, but the formula also differs between the two<a class=\"ref\" href=\"#src-4\">4<\/a>. Zinc oxide falls under other entries of the regulation.<\/div><\/details><details><summary>Is zinc PCA safe?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">The CIR panel judges 27 zinc salts safe in current uses if non-irritating<a class=\"ref\" href=\"#src-7\">7<\/a>. The European committee points out that zinc from cosmetics adds to dietary intake, which matters mainly in children<a class=\"ref\" href=\"#src-8\">8<\/a>. During pregnancy, as with any skincare product, a healthcare professional's advice remains the rule.<\/div><\/details><details><summary>Can you manufacture a zinc PCA product for my brand?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Yes. Our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/iso-22716-certified-cosmetics-manufacturer\/\">ISO 22716 certified<\/a> laboratory offers one catalog formula containing zinc PCA, a refreshing scalp spray, to customize, or a <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-formulation-lab\/\">custom formula<\/a> that includes it in another way. Free samples are included.<\/div><\/details><\/div><\/div><\/section>\n<section class=\"sec\" id=\"plus\" aria-labelledby=\"h-more\" style=\"padding-top:0\"><div class=\"wrap more-grid\">\n  <div><h2 class=\"h2\" id=\"h-more\">Further reading<\/h2><div class=\"hubs\"><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">Ingredient glossary<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-mens-grooming\/\">White label men&#x27;s grooming<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-formulation-lab\/\">Cosmetic formulation lab<\/a><\/div><\/div>\n  <ul class=\"more-list\"><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/trending-cosmetic-ingredients-2026\/\"><span><strong>Top 10 trending cosmetic ingredients in 2026<\/strong><small>The actives to add to a white label range<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/best-selling-cosmetics-france\/\"><span><strong>Best-selling cosmetic products in France in 2026<\/strong><small>Ranking by category, with the most common actives<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/eu-cosmetics-regulations-2026\/\"><span><strong>EU cosmetics regulations in 2026<\/strong><small>The regulatory framework to know before launching a range<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><\/div><\/section>\n<section class=\"sec sources\" id=\"sources\" aria-labelledby=\"h-s\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-s\">Sources<\/h2><p class=\"lede\">Peer-reviewed studies and official regulatory sources, checked on November 3, 2026.<\/p>\n  <ol class=\"src\"><li id=\"src-1\"><span>European Commission. <em>CosIng, entry ZINC PCA<\/em> (CAS 68107-75-5 \/ 15454-75-8, CE 268-475-9 \/ 239-473-5). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/38970\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-2\"><span>European Parliament and Council. <em>Regulation (EC) No 1223\/2009 on cosmetic products<\/em>, consolidated version of May 1, 2025: Annex III, entry 24 (water-soluble zinc salts). <a class=\"txt-link\" href=\"https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX:02009R1223-20250501\" target=\"_blank\" rel=\"noopener\">eur-lex.europa.eu<\/a><\/span><\/li><li id=\"src-3\"><span>Takino Y, Okura F, Kitazawa M, et al. <em>Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis.<\/em> Int J Cosmet Sci. 2012;34(1):23-28. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1468-2494.2011.00676.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1468-2494.2011.00676.x<\/a><span class=\"tag\">Ajinomoto<\/span><\/span><\/li><li id=\"src-4\"><span>Pirot F, Millet J, Kalia YN, Humbert P. <em>In vitro study of percutaneous absorption, cutaneous bioavailability and bioequivalence of zinc and copper from five topical formulations.<\/em> Skin Pharmacol. 1996;9(4):259-269. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1159\/000211423\" target=\"_blank\" rel=\"noopener\">doi:10.1159\/000211423<\/a><\/span><\/li><li id=\"src-5\"><span>Kezic S, Kammeyer A, Calkoen F, et al. <em>Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods.<\/em> Br J Dermatol. 2009;161(5):1098-1104. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1365-2133.2009.09342.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1365-2133.2009.09342.x<\/a><\/span><\/li><li id=\"src-6\"><span>Rawlings AV, Harding CR. <em>Moisturization and skin barrier function.<\/em> Dermatol Ther. 2004;17 Suppl 1:43-48. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/j.1396-0296.2004.04s1005.x\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/j.1396-0296.2004.04s1005.x<\/a><\/span><\/li><li id=\"src-7\"><span>Scott LN, Fiume M, Zhu J, et al. <em>Safety assessment of zinc salts as used in cosmetics.<\/em> Int J Toxicol. 2024;43(2_suppl):5S-69S. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1177\/10915818241227124\" target=\"_blank\" rel=\"noopener\">doi:10.1177\/10915818241227124<\/a><\/span><\/li><li id=\"src-8\"><span>SCCS, Granum B. <em>Opinion of the Scientific Committee on Consumer Safety (SCCS) - Final opinion on water-soluble zinc salts used in oral hygiene products.<\/em> Regul Toxicol Pharmacol. 2018;99:249-250. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1016\/j.yrtph.2018.09.007\" target=\"_blank\" rel=\"noopener\">doi:10.1016\/j.yrtph.2018.09.007<\/a><\/span><\/li><\/ol><\/div><\/section>\n\n<div class=\"fab\" id=\"fab\"><a class=\"btn\" href=\"#consultation\">Create a zinc PCA product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div><div class=\"scrim\" id=\"scrim\"><\/div><div class=\"pop\" id=\"pop\" role=\"dialog\" aria-modal=\"false\" aria-labelledby=\"pop-n\" hidden><div class=\"pop-n\" id=\"pop-n\"><\/div><div class=\"pop-body\" id=\"pop-body\"><\/div><div class=\"pop-foot\"><a class=\"txt-link\" id=\"pop-all\" href=\"#sources\">All sources<\/a><button class=\"pop-x\" type=\"button\" id=\"pop-x\">Close<\/button><\/div><\/div>\n<\/div>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@graph\": [{\"@type\": \"WebPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/zinc-pca\/#webpage\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/zinc-pca\/\", \"name\": \"Zinc PCA in Cosmetics: INCI, Limit and Studies\", \"inLanguage\": \"en-US\", \"datePublished\": \"2026-11-03\", \"dateModified\": \"2026-11-03\", \"author\": {\"@type\": \"Person\", \"name\": \"Mohamed El Hjouji\", \"jobTitle\": \"Founder and CEO\", \"worksFor\": {\"@type\": \"Organization\", \"name\": \"Carmel Cosmetics 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var(--line)!important;border-radius:14px!important;padding:13px 15px!important;height:auto!important;min-height:50px;box-shadow:none!important;transition:border-color .2s ease,box-shadow .2s ease,background-color .2s ease}\nbody .lpf-card .iti input[type=tel]{padding-left:52px!important}\nbody .lpf-card textarea{min-height:120px;resize:vertical}\nbody .lpf-card input:focus,body .lpf-card select:focus,body .lpf-card textarea:focus{outline:0!important;border-color:var(--teal)!important;background-color:var(--paper)!important;box-shadow:0 0 0 4px rgb(47 114 102\/.14)!important}\nbody .lpf-card ::placeholder{color:#8aa09d;opacity:1}\nbody .lpf-card .wpforms-submit-container{margin-top:6px!important;padding:0!important}\nbody .lpf-card button.wpforms-submit{width:100%!important;display:inline-flex!important;align-items:center;justify-content:center;gap:10px;font:650 16px\/1 var(--f-body)!important;color:#fff!important;background:var(--deep)!important;border:0!important;border-radius:99px!important;padding:19px 26px!important;min-height:58px;cursor:pointer;box-shadow:0 14px 30px -14px rgb(16 58 53\/.7)!important;transition:transform .16s cubic-bezier(.23,1,.32,1),background-color .2s ease}\n@media (hover:hover) and (pointer:fine){body .lpf-card button.wpforms-submit:hover{background:var(--teal)!important}}\nbody .lpf-card button.wpforms-submit:active{transform:scale(.98)}\nbody .lpf-card .wpforms-error,body .lpf-card label.wpforms-error,body .lpf-card em.wpforms-error{display:block;color:#b3261e!important;font-size:12.5px!important;margin-top:5px!important}\nbody .lpf-card input.wpforms-error,body .lpf-card select.wpforms-error,body .lpf-card textarea.wpforms-error{border-color:#d26a5f!important}\nbody .lpf-card .wpforms-confirmation-container-full{background:var(--mint)!important;border:0!important;border-radius:18px!important;color:var(--ink)!important;padding:22px!important}\n@media (max-width:520px){body .lpf-card .wpforms-field-name .wpforms-field-row{grid-template-columns:1fr}}\n<\/style><div class=\"dv-card-head\"><img loading=\"lazy\" class=\"dv-avatar\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/09\/lancer-marque-cosmetique-etape-1-expert-carmel-768x953.webp\" alt=\"Carmel Cosmetics Labs product specialist with a brand founder\" width=\"768\" height=\"953\" loading=\"lazy\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><div><h2>Tell us about your project<\/h2><p>A product specialist reviews your request and gets back to you on the channel you prefer.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0052f7c dv-form eael-wpforms-labels-yes eael-wpforms-form-button-custom elementor-widget elementor-widget-eael-wpforms\" data-id=\"0052f7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-wpforms.default\">\n\t\t\t\t\t            <div class=\"eael-contact-form eael-wpforms eael-wpforms-align-default\">\n                                <div class=\"wpforms-container wpforms-container-full wpforms-render-modern\" id=\"wpforms-28270\"><form id=\"wpforms-form-28270\" class=\"wpforms-validate wpforms-form wpforms-ajax-form\" data-formid=\"28270\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/en\/wp-json\/wp\/v2\/pages\/55680\" data-token=\"1a6c3a68ef8f7b7f2f6489a2cc53529c\" data-token-time=\"1794233794\"><div class=\"wpforms-head-container\"><div class=\"wpforms-title\">Lead EN \u2013 Demande de devis<\/div><div class=\"wpforms-description\">Tell us about your project. A product specialist will get back to you shortly.<\/div><\/div><noscript class=\"wpforms-error-noscript\">Please enable JavaScript in your browser to complete this form.<\/noscript><div id=\"wpforms-error-noscript\" style=\"display: none;\">Please enable JavaScript in your browser to complete this form.<\/div><div class=\"wpforms-field-container\"><div id=\"wpforms-28270-field_26-container\" class=\"wpforms-field wpforms-field-html\" data-field-type=\"html\" data-field-id=\"26\"><div id=\"wpforms-28270-field_26\" aria-errormessage=\"wpforms-28270-field_26-error\"><center>CONTACT INFORMATION<\/center><\/div><\/div><div id=\"wpforms-28270-field_8-container\" class=\"wpforms-field wpforms-field-name\" data-field-type=\"name\" data-field-id=\"8\"><fieldset><legend class=\"wpforms-field-label wpforms-label-hide\" aria-hidden=\"false\">Name <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><div class=\"wpforms-field-row wpforms-field-large\"><div class=\"wpforms-field-row-block wpforms-first wpforms-one-half\"><input type=\"text\" id=\"wpforms-28270-field_8\" class=\"wpforms-field-name-first wpforms-field-required\" name=\"wpforms[fields][8][first]\" placeholder=\"First Name\" aria-errormessage=\"wpforms-28270-field_8-error\" required><label for=\"wpforms-28270-field_8\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Pr\u00e9nom<\/label><\/div><div class=\"wpforms-field-row-block wpforms-one-half\"><input type=\"text\" id=\"wpforms-28270-field_8-last\" class=\"wpforms-field-name-last wpforms-field-required\" name=\"wpforms[fields][8][last]\" placeholder=\"Last Name\" aria-errormessage=\"wpforms-28270-field_8-last-error\" required><label for=\"wpforms-28270-field_8-last\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Nom<\/label><\/div><\/div><\/fieldset><\/div><div id=\"wpforms-28270-field_10-container\" class=\"wpforms-field wpforms-field-layout\" data-field-type=\"layout\" data-field-id=\"10\"><div class=\"wpforms-field-layout-columns wpforms-field-layout-preset-50-50\"><div class=\"wpforms-layout-column wpforms-layout-column-50\" ><div id=\"wpforms-28270-field_9-container\" class=\"wpforms-field wpforms-field-email\" data-field-type=\"email\" data-field-id=\"9\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_9\" aria-hidden=\"false\">Email <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"email\" id=\"wpforms-28270-field_9\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][9]\" placeholder=\"Email\" spellcheck=\"false\" aria-errormessage=\"wpforms-28270-field_9-error\" required><\/div><div id=\"wpforms-28270-field_39-container\" class=\"wpforms-field wpforms-field-select wpforms-field-select-style-modern\" data-field-type=\"select\" data-field-id=\"39\"><label class=\"wpforms-field-label\" for=\"wpforms-28270-field_39\">Preferred Contact Method<\/label><select id=\"wpforms-28270-field_39\" class=\"wpforms-field-medium choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-medium\" data-search-enabled=\"\" name=\"wpforms[fields][39]\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'>Please select your preferred method of contact<\/option><option value=\"WhatsApp\"  class=\"choice-1 depth-1\"  >WhatsApp<\/option><option value=\"Email\"  class=\"choice-2 depth-1\"  >Email<\/option><option value=\"Call only\"  class=\"choice-3 depth-1\"  >Call only<\/option><\/select><\/div><\/div><div class=\"wpforms-layout-column wpforms-layout-column-50\" ><div id=\"wpforms-28270-field_11-container\" class=\"wpforms-field wpforms-field-phone\" data-field-type=\"phone\" data-field-id=\"11\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_11\" aria-hidden=\"false\">Phone <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"tel\" id=\"wpforms-28270-field_11\" class=\"wpforms-field-medium wpforms-field-required wpforms-smart-phone-field\" data-rule-smart-phone-field=\"true\" name=\"wpforms[fields][11]\" placeholder=\"Phone\" aria-label=\"Phone\" aria-errormessage=\"wpforms-28270-field_11-error\" required><\/div><div id=\"wpforms-28270-field_13-container\" class=\"wpforms-field wpforms-field-text\" data-field-type=\"text\" data-field-id=\"13\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_13\" aria-hidden=\"false\">Company or brand name \/ website<\/label><input type=\"text\" id=\"wpforms-28270-field_13\" class=\"wpforms-field-medium\" name=\"wpforms[fields][13]\" placeholder=\"Company or brand name \/ website\" aria-errormessage=\"wpforms-28270-field_13-error\" ><\/div><\/div><\/div><\/div><div id=\"wpforms-28270-field_27-container\" class=\"wpforms-field wpforms-field-html\" data-field-type=\"html\" data-field-id=\"27\"><div id=\"wpforms-28270-field_27\" aria-errormessage=\"wpforms-28270-field_27-error\"><center>PROJECT INFORMATION<\/center><\/div><\/div><div id=\"wpforms-28270-field_35-container\" class=\"wpforms-field wpforms-field-checkbox wpforms-list-2-columns\" data-field-type=\"checkbox\" data-field-id=\"35\"><fieldset><legend class=\"wpforms-field-label\">Which cosmetics category interests you most? <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><ul id=\"wpforms-28270-field_35\" class=\"wpforms-field-required\"><li class=\"choice-1 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_1\" name=\"wpforms[fields][35][]\" value=\"Face care Products\" aria-errormessage=\"wpforms-28270-field_35_1-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_1\">Face care Products<\/label><\/li><li class=\"choice-2 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_2\" name=\"wpforms[fields][35][]\" value=\"Haircare Products\" aria-errormessage=\"wpforms-28270-field_35_2-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_2\">Haircare Products<\/label><\/li><li class=\"choice-3 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_3\" name=\"wpforms[fields][35][]\" value=\"Bodycare Products\" aria-errormessage=\"wpforms-28270-field_35_3-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_3\">Bodycare Products<\/label><\/li><li class=\"choice-4 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_4\" name=\"wpforms[fields][35][]\" value=\"Lipcare Products\" aria-errormessage=\"wpforms-28270-field_35_4-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_4\">Lipcare Products<\/label><\/li><li class=\"choice-5 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_5\" name=\"wpforms[fields][35][]\" value=\"Men&#039;s grooming Products\" aria-errormessage=\"wpforms-28270-field_35_5-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_5\">Men's grooming Products<\/label><\/li><li class=\"choice-6 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_6\" name=\"wpforms[fields][35][]\" value=\"Niche Products\" aria-errormessage=\"wpforms-28270-field_35_6-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_6\">Niche Products<\/label><\/li><li class=\"choice-7 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_7\" name=\"wpforms[fields][35][]\" value=\"Intimate Products\" aria-errormessage=\"wpforms-28270-field_35_7-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_7\">Intimate Products<\/label><\/li><li class=\"choice-8 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_8\" name=\"wpforms[fields][35][]\" value=\"Others\" aria-errormessage=\"wpforms-28270-field_35_8-error\" 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