{"id":54618,"date":"2026-11-02T22:01:27","date_gmt":"2026-11-02T22:01:27","guid":{"rendered":"https:\/\/carmelcosmeticslabs.com\/?page_id=54618"},"modified":"2026-11-05T12:18:48","modified_gmt":"2026-11-05T12:18:48","slug":"alpha-arbutin","status":"publish","type":"page","link":"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/alpha-arbutin\/","title":{"rendered":"Alpha-arbutin"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"54618\" class=\"elementor elementor-54618 elementor-54200 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-918b95d e-flex e-con-full e-con e-parent\" data-id=\"918b95d\" data-element_type=\"container\" data-e-type=\"container\" id=\"ing-alpha-arbutine\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d2cee2 elementor-widget elementor-widget-html\" data-id=\"6d2cee2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>.ig{--bg:#fbfdfc; --paper:#ffffff; --mint:#edf5f2; --mint-2:#dcebe6;\n  --ink:#10292a; --ink-2:#3d5557; --muted:#5b7173;\n  --teal:#2f7266; --teal-strong:#245a51; --on-teal:#ffffff;\n  --deep:#0f3a35; --deep-ink:#e9f4f1; --deep-muted:#a9c9c2; --deep-field:#174842;\n  --hair:rgba(16,41,42,.10); --btn-bg:#0f3a35; --btn-fg:#ffffff; --btn-hover:#134a43; --knob-bg:#ffffff; --knob-fg:#0f3a35; --btn-shadow:0 16px 34px -16px rgba(15,58,53,.7); --scrim:rgba(8,24,23,.32); --float:0 12px 32px rgba(8,24,23,.16),0 2px 6px rgba(8,24,23,.08);\n  --f-display:\"Proxima Nova\",\"Figtree\",system-ui,-apple-system,\"Segoe UI\",sans-serif;\n  --f-body:\"Lato\",system-ui,-apple-system,\"Segoe UI\",sans-serif;\n  --ease-out:cubic-bezier(0.23,1,0.32,1); --ease-drawer:cubic-bezier(0.32,0.72,0,1);\n  --wrap:1200px; --hdr:0px; --bm:0px; --bar:56px;\n  interpolate-size:allow-keywords;}\n.ig{background:var(--bg);color:var(--ink);font:400 17px\/1.6 var(--f-body);-webkit-font-smoothing:antialiased}\n.ig{overflow-x:clip}\n.ig *{box-sizing:border-box}\n.ig a{color:inherit}\n.ig h1,.ig h2,.ig h3,.ig h4{font-family:var(--f-display);font-weight:600;color:var(--ink);text-wrap:balance;margin:0}\n.ig p{margin:0}\n.ig button{font:inherit;color:inherit}\n.ig .wrap{max-width:var(--wrap);margin:0 auto;padding-left:max(16px,env(safe-area-inset-left,0px));padding-right:max(16px,env(safe-area-inset-right,0px))}\n@media (min-width:720px){.ig .wrap{padding-left:max(32px,env(safe-area-inset-left,0px));padding-right:max(32px,env(safe-area-inset-right,0px))}}\n.ig .sec{padding-block:96px;scroll-margin-top:calc(var(--hdr) + var(--bar))}\n@media (max-width:719px){.ig .sec{padding-block:64px}}\n.ig .h2{font-size:clamp(28px,3.4vw,40px);line-height:1.1;letter-spacing:-.02em}\n.ig .lede{color:var(--ink-2);max-width:62ch;margin-top:16px}\n.ig .txt-link{color:var(--teal-strong);text-decoration:underline;text-decoration-thickness:1px;text-underline-offset:3px;transition:color 150ms var(--ease-out)}\n.ig .txt-link:hover{color:var(--ink)}\n.ig :focus-visible{outline:2px solid var(--teal);outline-offset:3px;border-radius:4px}\n.ig .num{font-variant-numeric:tabular-nums}\n.ig .seg{display:inline-flex;flex-wrap:wrap;gap:4px;padding:4px;border-radius:999px;background:var(--mint)}\n.ig .seg button{border:0;background:transparent;cursor:pointer;height:36px;padding:0 16px;border-radius:999px;font:500 15px\/1 var(--f-display);color:var(--ink-2);display:inline-flex;align-items:center;gap:6px;\n  transition:background-color 150ms var(--ease-out),color 150ms var(--ease-out),transform 160ms var(--ease-out)}\n.ig .seg button:hover{color:var(--ink)}\n.ig .seg button:active{transform:scale(.97)}\n.ig .seg button[aria-pressed=\"true\"],.ig .seg button[aria-selected=\"true\"]{background:var(--paper);color:var(--ink)}\n.ig .seg button span{color:var(--muted);font-variant-numeric:tabular-nums}\n.ig .ref{font:600 12px\/1 var(--f-display);vertical-align:super;margin-left:2px;color:var(--teal-strong);text-decoration:none;display:inline-block;padding:3px 4px;border-radius:4px;cursor:pointer;transition:background-color 150ms var(--ease-out)}\n.ig .ref:hover,.ig .ref[aria-expanded=\"true\"]{background:var(--mint-2)}\n.ig .pop,.ig .pop *,.ig .fab,.ig .fab *{box-sizing:border-box}\n.ig .tag{display:inline-block;margin-left:6px;color:var(--muted);font-size:14px}\n.ig .pop{position:fixed;z-index:60;width:min(360px,calc(100vw - 32px));background:var(--paper);color:var(--ink);border-radius:12px;box-shadow:var(--float);padding:20px;\n  opacity:0;transform:scale(.96);pointer-events:none;transition:opacity 150ms var(--ease-out),transform 150ms var(--ease-out)}\n.ig .pop.open{opacity:1;transform:scale(1);pointer-events:auto}\n.ig .pop-n{font:600 13px\/1 var(--f-display);color:var(--teal-strong)}\n.ig .pop-body{margin-top:8px;font-size:15px;line-height:1.5;color:var(--ink-2)}\n.ig .pop-body em{font-style:normal;color:var(--ink);font-weight:700}\n.ig .pop-body a{color:var(--teal-strong);overflow-wrap:anywhere}\n.ig .pop-foot{margin-top:16px;display:flex;justify-content:space-between;gap:16px;font-size:14px}\n.ig .pop-x{border:0;background:none;cursor:pointer;color:var(--muted);padding:0}\n.ig .pop-x:hover{color:var(--ink)}\n.ig .scrim{position:fixed;inset:0;z-index:59;background:var(--scrim);opacity:0;pointer-events:none;transition:opacity 200ms var(--ease-out)}\n@media (max-width:640px){.ig .pop{left:0!important;right:0;top:auto!important;bottom:0;width:100%;border-radius:16px 16px 0 0;padding:24px max(20px,env(safe-area-inset-left,0px)) calc(24px + env(safe-area-inset-bottom,0px));\n    transform:translateY(100%);opacity:1;transition:transform 320ms var(--ease-drawer)}\n.ig .pop.open{transform:translateY(0)}\n.ig .pop::before{content:\"\";display:block;width:40px;height:4px;border-radius:2px;background:var(--mint-2);margin:-8px auto 16px}\n.ig .scrim.open{opacity:1;pointer-events:auto}}\n.ig .crumbs{padding-top:24px;font-size:14px;color:var(--muted)}\n.ig .crumbs ol{list-style:none;margin:0;padding:0;display:flex;flex-wrap:wrap;gap:8px}\n.ig .crumbs li+li::before{content:\"\u203a\";margin-right:8px}\n.ig .crumbs a{text-decoration:none;transition:color 150ms var(--ease-out)}\n.ig .crumbs a:hover{color:var(--ink)}\n.ig .hero{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:64px;align-items:center;padding-block:40px 72px}\n.ig .hero-copy{min-width:0}\n.ig .hero h1{font-size:clamp(44px,6vw,80px);line-height:.98;letter-spacing:-.035em}\n.ig .brief{margin-top:24px;font-size:19px;line-height:1.6;max-width:34em}\n.ig .byline{margin-top:24px;display:flex;align-items:center;gap:12px;font-size:14px;color:var(--muted)}\n.ig .avatar{width:40px;height:40px;border-radius:50%;background:var(--deep);color:var(--deep-ink);display:grid;place-items:center;font:600 14px\/1 var(--f-display);flex:none}\n.ig .byline strong{display:block;color:var(--ink);font:600 15px\/1.3 var(--f-display)}\n.ig .actions{margin-top:32px;display:flex;flex-wrap:wrap;align-items:center;gap:24px}\n.ig .btn{display:inline-flex;align-items:center;justify-content:center;gap:12px;padding:11px 11px 11px 26px;min-height:50px;border-radius:99px;border:0;cursor:pointer;white-space:nowrap;text-decoration:none;\n  background:var(--btn-bg);color:var(--btn-fg);font:700 15.5px\/1 var(--f-body);box-shadow:var(--btn-shadow);\n  transition:transform 160ms var(--ease-out),box-shadow 250ms ease,background-color 200ms ease}\n.ig .btn,.ig .fab .btn{color:var(--btn-fg)}\n.ig .btn:hover{background:var(--btn-hover)}\n.ig .btn:active{transform:scale(.97)}\n.ig .knob{width:28px;height:28px;border-radius:50%;background:var(--knob-bg);color:var(--knob-fg);display:grid;place-items:center;flex:none}\n.ig .knob svg{width:15px;height:15px;transition:transform 200ms var(--ease-out)}\n.ig .btn:hover .knob svg{transform:rotate(-45deg)}\n.ig .btn.sm{min-height:40px;padding:6px 6px 6px 18px;font-size:14.5px;gap:10px;box-shadow:none}\n.ig .btn.sm .knob{width:28px;height:28px}\n.ig .btn-ghost{display:inline-flex;align-items:center;min-height:50px;padding:0 24px;border-radius:99px;background:var(--mint);color:var(--ink);font:700 15.5px\/1 var(--f-body);text-decoration:none;transition:background-color 200ms ease,transform 160ms var(--ease-out)}\n.ig .btn-ghost:hover{background:var(--mint-2)}\n.ig .btn-ghost:active{transform:scale(.97)}\n.ig .hero-photo{margin:0;min-width:0}\n.ig .hero-photo img{display:block;width:100%;height:auto;aspect-ratio:4\/3;object-fit:cover;border-radius:4px}\n@media (max-width:900px){.ig .hero{grid-template-columns:1fr;gap:32px;padding-block:24px 56px}\n.ig .hero-photo{order:-1}\n.ig .hero-photo img{aspect-ratio:16\/10}\n.ig .brief{font-size:18px}}\n.ig .bar{position:sticky;top:var(--hdr);z-index:40;background:var(--bg);box-shadow:0 1px 0 var(--hair)}\n.ig .bar-in{display:flex;align-items:center;gap:24px;height:var(--bar)}\n.ig .bar nav{flex:1;min-width:0;overflow-x:auto;scrollbar-width:none;-webkit-mask-image:linear-gradient(90deg,#000 calc(100% - 32px),transparent)}\n.ig .bar nav::-webkit-scrollbar{display:none}\n.ig .bar ul{list-style:none;margin:0;padding:0 32px 0 0;display:flex;gap:4px;width:max-content}\n.ig .bar a{display:flex;align-items:center;height:36px;padding:0 12px;border-radius:999px;text-decoration:none;font:500 15px\/1 var(--f-display);color:var(--muted);white-space:nowrap;transition:color 150ms var(--ease-out),background-color 150ms var(--ease-out)}\n.ig .bar a:hover{color:var(--ink)}\n.ig .bar a.on{color:var(--ink);background:var(--mint)}\n.ig .bar a.btn{color:var(--btn-fg);background:var(--btn-bg);height:auto;padding:6px 6px 6px 18px;font:700 14.5px\/1 var(--f-body)}\n.ig .bar a.btn:hover{background:var(--btn-hover);color:var(--btn-fg)}\n.ig .bar .btn{opacity:0;transform:translateY(4px);pointer-events:none;transition:opacity 200ms var(--ease-out),transform 200ms var(--ease-out),background-color 200ms ease}\n.ig .bar.past .btn{opacity:1;transform:none;pointer-events:auto}\n.ig .bar-prog{position:absolute;left:0;bottom:-1px;height:2px;width:100%;background:var(--teal);transform-origin:0 50%;transform:scaleX(0)}\n@media (max-width:900px){.ig .bar .btn{display:none}\n.ig .bar-in{gap:0}}\n.ig .fab{position:fixed;left:0;right:0;bottom:var(--bm);z-index:45;padding:12px max(16px,env(safe-area-inset-left,0px)) calc(12px + env(safe-area-inset-bottom,0px));\n  transform:translateY(calc(100% + var(--bm)));transition:transform 280ms var(--ease-drawer);pointer-events:none}\n.ig .fab .btn{width:100%;justify-content:space-between;box-shadow:var(--float);pointer-events:auto}\n.ig .fab.show{transform:none}\n@media (min-width:901px){.ig .fab{display:none}}\n.ig .id-grid{display:grid;grid-template-columns:minmax(0,.8fr) minmax(0,1.6fr);gap:56px;align-items:start}\n.ig .spec{margin:0;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0 40px}\n.ig .spec div{padding-block:16px;border-top:1px solid var(--hair);min-width:0}\n.ig .spec dt{font-size:14px;color:var(--muted)}\n.ig .spec dd{margin:4px 0 0;font:500 18px\/1.4 var(--f-display);color:var(--ink);overflow-wrap:anywhere;display:flex;flex-wrap:wrap;align-items:center;gap:4px 10px}\n.ig .spec dd small{flex-basis:100%;font:400 15px\/1.5 var(--f-body);color:var(--ink-2)}\n.ig .copy{border:0;background:var(--mint);cursor:pointer;height:28px;padding:0 10px;border-radius:999px;font:500 13px\/1 var(--f-display);color:var(--ink-2);display:inline-flex;align-items:center;gap:6px;\n  transition:background-color 150ms var(--ease-out),color 150ms var(--ease-out),transform 160ms var(--ease-out)}\n.ig .copy:hover{background:var(--mint-2);color:var(--ink)}\n.ig .copy:active{transform:scale(.96)}\n.ig .copy svg{width:14px;height:14px}\n.ig .copy.done{background:var(--teal);color:var(--on-teal)}\n.ig .id-grid>div:first-child{position:sticky;top:calc(var(--hdr) + var(--bar) + 32px)}\n@media (max-width:900px){.ig .id-grid{grid-template-columns:1fr;gap:24px}\n.ig .id-grid>div:first-child{position:static}}\n@media (max-width:560px){.ig .spec{grid-template-columns:1fr}}\n.ig .research{background:var(--paper)}\n.ig .r-head{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:24px 56px;align-items:end}\n.ig .r-tools{margin-top:40px;display:flex;flex-wrap:wrap;justify-content:space-between;align-items:center;gap:16px 32px}\n.ig .legend{display:flex;flex-wrap:wrap;gap:8px 20px;font-size:14px;color:var(--ink-2)}\n.ig .domain{margin-top:64px;display:grid;grid-template-columns:minmax(0,220px) minmax(0,1fr);gap:40px}\n.ig .domain[hidden]{display:none}\n.ig .domain h3{font-size:24px;line-height:1.2;letter-spacing:-.01em;position:sticky;top:calc(var(--hdr) + var(--bar) + 24px);align-self:start}\n.ig .domain h3 span{display:block;margin-top:6px;font:400 15px\/1.5 var(--f-body);color:var(--muted);letter-spacing:0}\n.ig .finds{display:grid;gap:12px}\n.ig .find{background:var(--mint);border-radius:12px;padding:24px 28px;display:grid;gap:10px}\n.ig .find-top{display:flex;justify-content:space-between;align-items:flex-start;gap:16px 24px}\n.ig .find h4{font-size:19px;line-height:1.35}\n.ig .meta{display:flex;flex-wrap:wrap;gap:6px}\n.ig .meta span{background:var(--paper);border-radius:999px;padding:5px 10px;font:500 13px\/1.2 var(--f-display);color:var(--ink-2)}\n.ig .find p{color:var(--ink-2);font-size:16px;max-width:64ch}\n.ig .lvl{display:inline-flex;align-items:center;gap:8px;font:500 14px\/1.2 var(--f-display);color:var(--ink);white-space:nowrap;flex:none}\n.ig .dot{width:10px;height:10px;border-radius:50%;flex:none}\n.ig .dot.c{background:var(--teal)}\n.ig .dot.r{background:linear-gradient(90deg,var(--teal) 50%,transparent 50%);box-shadow:inset 0 0 0 2px var(--teal)}\n.ig .dot.v{box-shadow:inset 0 0 0 2px var(--teal)}\n.ig .frame{margin-top:56px;max-width:72ch;font-size:15px;color:var(--muted)}\n@media (max-width:900px){.ig .r-head{grid-template-columns:1fr}\n.ig .domain{grid-template-columns:1fr;gap:16px;margin-top:48px}\n.ig .domain h3{position:static}}\n@media (max-width:560px){.ig .find{padding:20px}\n.ig .find-top{flex-direction:column}\n.ig .r-tools .seg{width:100%;overflow-x:auto;flex-wrap:nowrap;scrollbar-width:none}\n.ig .r-tools .seg button{flex:none}}\n.ig .dose{display:grid;grid-template-columns:minmax(0,.9fr) minmax(0,1.5fr);gap:56px;align-items:center}\n.ig .scale{position:relative;padding-top:104px;padding-bottom:48px}\n.ig .track{position:relative;height:12px;border-radius:6px;background:var(--mint-2)}\n.ig .band{position:absolute;inset:0 auto 0 20%;width:30%;border-radius:6px;background:var(--teal)}\n.ig .ticks{position:absolute;left:0;right:0;top:28px}\n.ig .tick{position:absolute;transform:translateX(-50%);font:500 13px\/1 var(--f-display);color:var(--muted);white-space:nowrap}\n.ig .tick:first-child{transform:none}\n.ig .tick:last-child{transform:translateX(-100%)}\n.ig .pin{position:absolute;bottom:calc(100% + 12px);transform:translateX(-50%);width:200px;text-align:center}\n.ig .pin strong{display:block;font:600 28px\/1 var(--f-display);color:var(--teal-strong)}\n.ig .pin span{display:block;margin-top:6px;font-size:14px;line-height:1.4;color:var(--ink-2)}\n.ig .pin::after{content:\"\";display:block;width:2px;height:16px;background:var(--teal);margin:8px auto 0}\n@media (max-width:900px){.ig .dose{grid-template-columns:1fr;gap:24px}}\n@media (max-width:560px){.ig .scale{padding-top:0}\n.ig .pin{position:static;transform:none;width:auto;text-align:left;display:flex;gap:12px;align-items:baseline;margin-bottom:12px}\n.ig .pin::after{display:none}\n.ig .pin strong{font-size:22px;min-width:48px}\n.ig .pins-m{margin-bottom:20px}}\n.ig .products{background:var(--mint)}\n.ig .p-head{display:flex;flex-wrap:wrap;justify-content:space-between;align-items:end;gap:24px}\n.ig .p-tabs{display:none}\n.ig .p-cols{margin-top:40px;display:grid;grid-template-columns:repeat(var(--pc,3),minmax(0,1fr));gap:24px}\n.ig .p-col{background:var(--paper);border-radius:12px;padding:28px;display:flex;flex-direction:column}\n.ig .p-col h3{font-size:22px;letter-spacing:-.01em;display:flex;align-items:baseline;gap:12px}\n.ig .p-col h3 .count{font-size:40px;line-height:1;color:var(--teal-strong);letter-spacing:-.03em}\n.ig .p-col p{margin-top:10px;font-size:15px;color:var(--ink-2)}\n.ig .p-col ul{list-style:none;margin:20px 0 0;padding:0}\n.ig .p-col li a{display:grid;grid-template-columns:minmax(0,1fr) auto 16px;align-items:center;gap:12px;min-height:44px;border-top:1px solid var(--hair);text-decoration:none;font-size:16px;transition:color 150ms var(--ease-out)}\n.ig .p-col li a .n{color:var(--muted);font-variant-numeric:tabular-nums}\n.ig .p-col li a svg{width:16px;height:16px;color:var(--muted);transform:translateX(-4px);opacity:0;transition:transform 150ms var(--ease-out),opacity 150ms var(--ease-out)}\n.ig .p-col li a:hover{color:var(--teal-strong)}\n.ig .p-col li a:hover svg{opacity:1;transform:none;color:var(--teal-strong)}\n.ig .feat{margin-top:auto;padding-top:20px}\n.ig .feat a{display:flex;align-items:center;justify-content:space-between;gap:12px;padding:12px 14px;border-radius:10px;background:var(--mint);text-decoration:none;font:500 15px\/1.3 var(--f-display);transition:background-color 150ms var(--ease-out)}\n.ig .feat a+a{margin-top:6px}\n.ig .feat a:hover{background:var(--mint-2)}\n.ig .feat small{display:block;font:400 13px\/1.3 var(--f-body);color:var(--muted)}\n.ig .feat svg{width:16px;height:16px;flex:none;color:var(--teal-strong)}\n.ig .pairs{margin-top:40px;display:flex;flex-wrap:wrap;align-items:baseline;gap:10px}\n.ig .pairs p{color:var(--ink-2);margin-right:6px}\n.ig a.chip{text-decoration:none;transition:background-color 150ms var(--ease-out)}\n.ig a.chip:hover{background:var(--mint-2)}\n.ig #plus a.chip{background:var(--mint)}\n.ig #plus a.chip:hover{background:var(--mint-2)}\n.ig .chip{display:inline-flex;gap:6px;align-items:baseline;padding:8px 14px;border-radius:999px;background:var(--paper);font:500 15px\/1 var(--f-display)}\n.ig .chip span{color:var(--muted);font-variant-numeric:tabular-nums}\n@media (max-width:900px){.ig .p-tabs{display:inline-flex;width:100%}\n.ig .p-tabs button{flex:1;justify-content:center}\n.ig .p-cols{grid-template-columns:1fr;margin-top:20px}\n.ig .p-col:not(.on){display:none}\n.ig .p-col h3 .count{display:none}}\n.ig .c-head{display:flex;flex-wrap:wrap;justify-content:space-between;align-items:end;gap:24px}\n.ig .c-pick{display:none}\n.ig .tbl-wrap{margin-top:40px}\n.ig table.cmp{width:100%;border-collapse:collapse;font-size:16px;table-layout:fixed}\n.ig .cmp th,.ig .cmp td{text-align:left;vertical-align:top;padding:16px 20px 16px 0;border-top:1px solid var(--hair);overflow-wrap:anywhere}\n.ig .cmp thead th{font:600 17px\/1.3 var(--f-display);border-top:0;padding-bottom:12px}\n.ig .cmp thead th:nth-child(2){color:var(--teal-strong)}\n.ig .cmp tbody th{font:500 15px\/1.4 var(--f-display);color:var(--muted);width:16%}\n.ig .cmp td{color:var(--ink-2)}\n.ig .cmp td:nth-child(2),.ig .cmp thead th:nth-child(2){color:var(--ink);padding-left:16px}\n.ig .cmp thead th:nth-child(2){color:var(--teal-strong)}\n.ig .cmp col.me{background:var(--mint)}\n@media (max-width:760px){.ig .c-pick{display:inline-flex;width:100%;margin-top:24px}\n.ig .c-pick button{flex:1;justify-content:center;padding:0 8px}\n.ig .tbl-wrap{margin-top:16px}\n.ig table.cmp{table-layout:auto}\n.ig .cmp th,.ig .cmp td{padding:14px 12px 14px 0;font-size:15px;overflow-wrap:normal}\n.ig .cmp td:nth-child(2),.ig .cmp thead th:nth-child(2){padding-left:12px}\n.ig .cmp tbody th{width:28%}\n.ig .cmp[data-c=\"3\"] :is(th,.ig td):nth-child(4),.ig .cmp[data-c=\"3\"] :is(th,.ig td):nth-child(5),.ig .cmp[data-c=\"4\"] :is(th,.ig td):nth-child(3),.ig .cmp[data-c=\"4\"] :is(th,.ig td):nth-child(5),.ig .cmp[data-c=\"5\"] :is(th,.ig td):nth-child(3),.ig .cmp[data-c=\"5\"] :is(th,.ig td):nth-child(4){display:none}}\n.ig .faq-grid{display:grid;grid-template-columns:minmax(0,.8fr) minmax(0,1.6fr);gap:56px}\n.ig .faq details{border-top:1px solid var(--hair)}\n.ig .faq details:last-child{border-bottom:1px solid var(--hair)}\n.ig .faq summary{list-style:none;cursor:pointer;display:flex;justify-content:space-between;gap:24px;padding-block:20px;font:600 19px\/1.35 var(--f-display);transition:color 150ms var(--ease-out)}\n.ig .faq summary:hover{color:var(--teal-strong)}\n.ig .faq summary::-webkit-details-marker{display:none}\n.ig .faq summary svg{flex:none;width:20px;height:20px;margin-top:3px;color:var(--teal);transition:transform 200ms var(--ease-out)}\n.ig .faq details[open] summary svg{transform:rotate(45deg)}\n.ig .faq details::details-content{block-size:0;overflow:hidden;transition:block-size 240ms var(--ease-out),content-visibility 240ms allow-discrete}\n.ig .faq details[open]::details-content{block-size:auto}\n.ig .faq .a{padding-bottom:24px;color:var(--ink-2);max-width:64ch}\n@media (max-width:900px){.ig .faq-grid{grid-template-columns:1fr;gap:24px}}\n.ig .more-grid{display:grid;grid-template-columns:minmax(0,.8fr) minmax(0,1.6fr);gap:56px}\n.ig .more-list{list-style:none;margin:0;padding:0}\n.ig .more-list a{display:grid;grid-template-columns:minmax(0,1fr) auto;align-items:center;gap:16px;padding-block:18px;border-top:1px solid var(--hair);text-decoration:none;transition:color 150ms var(--ease-out)}\n.ig .more-list li:last-child a{border-bottom:1px solid var(--hair)}\n.ig .more-list strong{display:block;font:600 18px\/1.35 var(--f-display);color:var(--ink);transition:color 150ms var(--ease-out)}\n.ig .more-list small{display:block;margin-top:4px;font-size:14px;color:var(--muted)}\n.ig .more-list svg{width:18px;height:18px;color:var(--muted);transition:transform 150ms var(--ease-out),color 150ms var(--ease-out)}\n.ig .more-list a:hover strong{color:var(--teal-strong)}\n.ig .more-list a:hover svg{transform:translateX(3px);color:var(--teal-strong)}\n.ig .hubs{margin-top:24px;display:flex;flex-wrap:wrap;gap:10px}\n.ig .c-link{color:inherit;text-decoration:underline;text-decoration-thickness:1px;text-underline-offset:3px;text-decoration-color:var(--deep-muted)}\n@media (max-width:900px){.ig .more-grid{grid-template-columns:1fr;gap:24px}}\n.ig .sources{background:var(--paper)}\n.ig .src{margin:40px 0 0;padding:0;list-style:none;counter-reset:s;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px 48px}\n.ig .src li{counter-increment:s;display:grid;grid-template-columns:32px minmax(0,1fr);font-size:15px;line-height:1.5;color:var(--ink-2);scroll-margin-top:calc(var(--hdr) + var(--bar) + 24px);border-radius:8px;transition:background-color 400ms var(--ease-out),box-shadow 400ms var(--ease-out)}\n.ig .src li::before{content:counter(s);font:600 15px\/1.5 var(--f-display);color:var(--teal-strong)}\n.ig .src li:target,.ig .src li.flash{background:var(--mint);box-shadow:0 0 0 8px var(--mint)}\n.ig .src em{font-style:normal;color:var(--ink)}\n.ig .src a{overflow-wrap:anywhere}\n@media (max-width:760px){.ig .src{grid-template-columns:1fr}}\n.ig .consult{background:var(--deep);color:var(--deep-ink)}\n.ig .c-grid{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.1fr);gap:64px;align-items:start}\n.ig .consult h2{color:var(--deep-ink);font-size:clamp(32px,4vw,48px);line-height:1.05;letter-spacing:-.025em}\n.ig .consult .lede{color:var(--deep-muted)}\n.ig .c-points{list-style:none;margin:32px 0 0;padding:0;display:grid;gap:14px}\n.ig .c-points li{display:flex;gap:12px;align-items:flex-start;color:var(--deep-ink)}\n.ig .c-points svg{width:20px;height:20px;flex:none;color:var(--deep-muted);margin-top:2px}\n.ig form.lead{background:var(--deep-field);border-radius:16px;padding:32px;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}\n.ig .f{display:grid;gap:6px;min-width:0}\n.ig .f.full{grid-column:1\/-1}\n.ig .f label{font:500 14px\/1.3 var(--f-display);color:var(--deep-muted)}\n.ig .f label b{font-weight:500;color:var(--deep-ink)}\n.ig .f input,.ig .f select,.ig .f textarea{width:100%;min-height:48px;font:400 16px\/1.4 var(--f-body);color:var(--deep-ink);background:var(--deep);border:1px solid rgba(233,244,241,.14);border-radius:8px;padding:12px 14px;transition:border-color 150ms var(--ease-out)}\n.ig .f textarea{min-height:112px;resize:vertical}\n.ig .f input:focus,.ig .f select:focus,.ig .f textarea:focus{outline:none;border-color:var(--deep-muted)}\n.ig .f .err{display:none;font-size:13px;color:#ffb4a8}\n.ig .f.bad input{border-color:#ffb4a8}\n.ig .f.bad .err{display:block}\n.ig form.lead .btn,.ig form.lead .btn{grid-column:1\/-1;justify-self:start;background:#e9f4f1;color:#0f3a35;box-shadow:none}\n.ig form.lead .btn:hover{background:#ffffff}\n.ig form.lead .btn .knob{background:#0f3a35;color:#ffffff}\n@media (max-width:560px){.ig form.lead .btn{justify-self:stretch;justify-content:space-between}}\n.ig .f-note{grid-column:1\/-1;font-size:13px;color:var(--deep-muted)}\n.ig .f-ok{grid-column:1\/-1;display:flex;gap:12px;align-items:flex-start;padding:16px;border-radius:10px;background:var(--deep);font:500 15px\/1.45 var(--f-display);color:var(--deep-ink)}\n.ig .f-ok[hidden]{display:none}\n.ig .f-ok svg{width:20px;height:20px;flex:none;color:var(--deep-muted)}\n@media (max-width:900px){.ig .c-grid{grid-template-columns:1fr;gap:32px}}\n@media (max-width:560px){.ig form.lead{grid-template-columns:1fr;padding:20px}}\n@media (prefers-reduced-motion:reduce){.ig *,.ig *::details-content,.ig .pop,.ig .scrim,.ig .fab{transition:none!important}}\n.ig .hero h1.h1-long{font-size:clamp(38px,4.6vw,60px);line-height:1.02}\n.ig .pins-list{display:none;list-style:none;margin:0 0 20px;padding:0;order:-1}\n.ig .pins-list li{display:flex;gap:12px;align-items:baseline;margin-bottom:10px;font-size:14px;line-height:1.4;color:var(--ink-2)}\n.ig .pins-list strong{font:600 22px\/1 var(--f-display);color:var(--teal-strong);min-width:72px}\n.ig .scale.dense{display:flex;flex-direction:column;padding-top:0}\n.ig .scale.dense .pins-list{display:block}\n.ig .scale.dense .track .pin{display:none}\n@media (max-width:560px){.ig .scale{display:flex;flex-direction:column;padding-top:0}.ig .pins-list{display:block}.ig .track .pin{display:none}}\n<\/style>\n<div class=\"ig\" data-ing=\"alpha-arbutine\" lang=\"en\" data-copy=\"Copy\" data-copied=\"Copied\">\n<nav class=\"crumbs wrap\" aria-label=\"Breadcrumb\"><ol>\n  <li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/\">Home<\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">Ingredient glossary<\/a><\/li><li aria-current=\"page\">Alpha-arbutin<\/li><\/ol><\/nav>\n<header class=\"wrap hero\" id=\"top\">\n  <div class=\"hero-copy\">\n    <h1>Alpha-arbutin<\/h1>\n    <p class=\"brief\">Alpha-arbutin is a hydroquinone glycoside obtained by enzymatic synthesis<a class=\"ref\" href=\"#src-3\">3<\/a>. In the lab, it slows melanin formation<a class=\"ref\" href=\"#src-4\">4<\/a>, more strongly than beta-arbutin on human tyrosinase<a class=\"ref\" href=\"#src-5\">5<\/a>. Clinical evidence remains thin. The EU limits it to 2% in face cream and 0.5% in body lotion<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p>\n    <div class=\"byline\"><span class=\"avatar\" aria-hidden=\"true\">ME<\/span>\n      <span><strong>Mohamed El Hjouji<\/strong>Founder and CEO \u00b7 Updated <time datetime=\"2026-11-02\">November 2, 2026<\/time> \u00b7 Reading time 7 min<\/span><\/div>\n    <div class=\"actions\">\n      <a class=\"btn\" href=\"#consultation\">Create an alpha-arbutin product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a>\n      <a class=\"btn-ghost\" href=\"#recherche\">Read the studies<\/a>\n    <\/div>\n  <\/div>\n  <figure class=\"hero-photo\"><img fetchpriority=\"high\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel.webp\" srcset=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel-300x224.webp 300w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel-441x329.webp 441w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel-768x574.webp 768w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel-990x740.webp 990w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel-1024x765.webp 1024w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel.webp 1400w, https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/11\/alpha-arbutine-ingredient-cosmetique-carmel.webp 1400w\" sizes=\"(max-width:900px) 92vw, 46vw\" width=\"1400\" height=\"1046\" alt=\"White alpha-arbutin powder in macro view on a sage green ceramic surface\" fetchpriority=\"high\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><\/figure>\n<\/header>\n<div class=\"bar\" id=\"bar\"><div class=\"wrap bar-in\">\n  <nav aria-label=\"On this page\"><ul><li><a href=\"#identite\">Identity<\/a><\/li><li><a href=\"#recherche\">Research<\/a><\/li><li><a href=\"#concentrations\">Concentrations<\/a><\/li><li><a href=\"#produits\">Products<\/a><\/li><li><a href=\"#comparatif\">Comparison<\/a><\/li><li><a href=\"#faq\">Questions<\/a><\/li><li><a href=\"#plus\">Reading<\/a><\/li><li><a href=\"#sources\">Sources<\/a><\/li><\/ul><\/nav>\n  <a class=\"btn sm\" href=\"#consultation\" tabindex=\"-1\">Create my product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div>\n  <span class=\"bar-prog\" id=\"prog\" aria-hidden=\"true\"><\/span><\/div>\n<section class=\"sec\" id=\"identite\" aria-labelledby=\"h-id\"><div class=\"wrap id-grid\">\n  <div><h2 class=\"h2\" id=\"h-id\">Alpha-arbutin at a glance<\/h2>\n  <p class=\"lede\">Entry from our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">cosmetic ingredient glossary<\/a>. Data from the European Commission's CosIng database<a class=\"ref\" href=\"#src-1\">1<\/a>, Regulation (EU) 2024\/996<a class=\"ref\" href=\"#src-2\">2<\/a> and the opinion of the SCCS scientific committee<a class=\"ref\" href=\"#src-3\">3<\/a>. Copy the identifiers in one click for your files.<\/p><\/div>\n  <dl class=\"spec\"><div><dt>INCI name<\/dt><dd><span class=\"\">ALPHA-ARBUTIN<\/span><button class=\"copy\" type=\"button\" data-copy=\"ALPHA-ARBUTIN\" aria-label=\"Copy: INCI name\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><\/dd><\/div><div><dt>Other names<\/dt><dd>4-Hydroxyphenyl-alpha-D-glucopyranoside<small>Alpha isomer of arbutin<a class=\"ref\" href=\"#src-3\">3<\/a><\/small><\/dd><\/div><div><dt>CAS number<\/dt><dd><span class=\"num\">84380-01-8<\/span><button class=\"copy\" type=\"button\" data-copy=\"84380-01-8\" aria-label=\"Copy: CAS number\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><\/dd><\/div><div><dt>EC number<\/dt><dd><span class=\"num\">617-561-8<\/span><button class=\"copy\" type=\"button\" data-copy=\"617-561-8\" aria-label=\"Copy: EC number\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"9\" y=\"9\" width=\"11\" height=\"11\" rx=\"2\"\/><path d=\"M5 15V5a2 2 0 0 1 2-2h8\"\/><\/svg>Copy<\/button><\/dd><\/div><div><dt>Formula<\/dt><dd class=\"num\">C\u2081\u2082H\u2081\u2086O\u2087<small>Hydroquinone glycoside<a class=\"ref\" href=\"#src-3\">3<\/a><\/small><\/dd><\/div><div><dt>Origin<\/dt><dd>Enzymatic synthesis<small>Glycosylation of hydroquinone; beta-arbutin, by contrast, occurs in the leaves and bark of many plants<a class=\"ref\" href=\"#src-3\">3<\/a><\/small><\/dd><\/div><div><dt>CosIng functions<\/dt><dd>Antioxidant, skin lightening<small>Also a skin conditioning agent<a class=\"ref\" href=\"#src-1\">1<\/a><\/small><\/dd><\/div><div><dt>EU status<\/dt><dd>Restricted<small>Annex III no. 377: 2% in face cream, 0.5% in body lotion. Hydroquinone must remain at the level of unavoidable traces<a class=\"ref\" href=\"#src-2\">2<\/a><\/small><\/dd><\/div><div><dt>Allergen to declare<\/dt><dd>No<\/dd><\/div><div><dt>Safety<\/dt><dd>Judged safe at the permitted levels<small>SCCS opinion of January 31, 2023, including cumulative exposure with arbutin<a class=\"ref\" href=\"#src-3\">3<\/a><\/small><\/dd><\/div><\/dl><\/div><\/section>\n<section class=\"sec research\" id=\"recherche\" aria-labelledby=\"h-r\"><div class=\"wrap\">\n  <div class=\"r-head\"><div><h2 class=\"h2\" id=\"h-r\">What the research says<\/h2>\n  <p class=\"lede\">Each result shows the protocol and the level of evidence. The higher the level, the better the result carries over to a finished formula.<\/p><\/div><\/div>\n  <div class=\"r-tools\"><div class=\"seg\" role=\"group\" aria-label=\"Filter by area\" id=\"rfilter\"><button type=\"button\" aria-pressed=\"true\" data-d=\"all\">All <span>6<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"visage\">Face <span>3<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"securite\">Safety <span>2<\/span><\/button><button type=\"button\" aria-pressed=\"false\" data-d=\"derm\">Experts <span>1<\/span><\/button><\/div><div class=\"legend\" aria-label=\"Levels of evidence\"><span class=\"lvl\"><i class=\"dot c\"><\/i>Clinical trial<\/span><span class=\"lvl\"><i class=\"dot r\"><\/i>Review or consensus<\/span><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><\/div>\n  <div class=\"domain\" data-d=\"visage\"><h3>Facial skin<span>Skincare<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Less melanin in a human skin model<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><div class=\"meta\"><span>0.5 mM on cells; 250 \u00b5g on reconstructed skin<\/span><span>Human melanoma cells<\/span><span>Manufacturer study<\/span><\/div><p>Melanin synthesis falls to 76% of that of control cells, and to 40% on the skin model, with no toxicity to the cells. These are lab results, not a demonstrated effect on living skin<a class=\"ref\" href=\"#src-4\">4<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>More potent than beta-arbutin on tyrosinase<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><div class=\"meta\"><span>Human and mouse tyrosinase<\/span><span>Two lab studies<\/span><span>Industry studies<\/span><\/div><p>On human tyrosinase, the inhibition constant of alpha-arbutin is 20 times lower than that of arbutin: the inhibition is stronger<a class=\"ref\" href=\"#src-5\">5<\/a>. On mouse melanoma tyrosinase, it is about 10 times more active (IC50 of 0.48 mM) but does not inhibit mushroom tyrosinase: the result depends on the enzyme tested<a class=\"ref\" href=\"#src-6\">6<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>An experimental gel tested on volunteers<\/h4><span class=\"lvl\"><i class=\"dot c\"><\/i>Clinical trial<\/span><\/div><div class=\"meta\"><span>Ethosome gel<\/span><span>Volunteers, number not given in the abstract<\/span><\/div><p>The formulation improves the melanin index, hydration and elasticity of the skin. The abstract gives neither the sample size nor the values, and the formula is experimental: the effect of alpha-arbutin alone is not isolated<a class=\"ref\" href=\"#src-7\">7<\/a>.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"securite\"><h3>Safety assessment<span>SCCS<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>Safe up to 2% in face cream and 0.5% in body lotion<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>SCCS opinion<\/span><\/div><div class=\"meta\"><span>SCCS\/1642\/22<\/span><span>January 31, 2023<\/span><\/div><p>The committee judges alpha-arbutin safe at these levels, including when used together, and cumulative exposure with arbutin without risk. Hydroquinone must remain at the level of unavoidable traces<a class=\"ref\" href=\"#src-3\">3<\/a>. Regulation (EU) 2024\/996 adopts these limits<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p><\/article><article class=\"find\"><div class=\"find-top\"><h4>Low skin absorption<\/h4><span class=\"lvl\"><i class=\"dot v\"><\/i>Laboratory<\/span><\/div><div class=\"meta\"><span>In vitro<\/span><span>Human skin, 3 donors<\/span><span>Skin frozen for 8 days<\/span><\/div><p>Total skin absorption reaches 0.27 \u00b1 0.13% of the dose. The SCCS uses 0.53% in its calculations and notes the low number of donors<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/p><\/article><\/div><\/div><div class=\"domain\" data-d=\"derm\"><h3>What experts say<span>Dermatology<\/span><\/h3><div class=\"finds\"><article class=\"find\"><div class=\"find-top\"><h4>A cosmetic alternative, quality trials to come<\/h4><span class=\"lvl\"><i class=\"dot r\"><\/i>Review<\/span><\/div><div class=\"meta\"><span>Literature reviews<\/span><span>2016 and 2021<\/span><\/div><p>Arbutin and its derivatives, kojic acid and nicotinamide were developed as cosmetic alternatives to medical agents with side effects<a class=\"ref\" href=\"#src-9\">9<\/a>. A 2021 review considers that quality trials, on larger samples, are still needed to confirm the efficacy and safety of alpha-arbutin<a class=\"ref\" href=\"#src-8\">8<\/a>.<\/p><\/article><\/div><\/div>\n  <p class=\"frame\">This page summarizes published literature on a cosmetic ingredient. It does not describe the effect of a finished product, which depends on its formula, and it is not medical advice. Evidence on alpha-arbutin comes mostly from lab studies; clinical trials on healthy skin are rare and the published studies often cover medical uses, which we do not report. Several studies were run by industry; this is indicated in the sources.<\/p><\/div><\/section>\n<section class=\"sec\" id=\"concentrations\" aria-labelledby=\"h-c\"><div class=\"wrap dose\">\n  <div><h2 class=\"h2\" id=\"h-c\">Concentrations used in studies<\/h2><p class=\"lede\">No trial cited specifies the concentration tested on skin. The reference levels are those assessed by the SCCS and set by the regulation: 2% in face cream and 0.5% in body lotion<a class=\"ref\" href=\"#src-3\">3<\/a><a class=\"ref\" href=\"#src-2\">2<\/a>.<\/p><\/div>\n  <div class=\"scale\" role=\"img\" aria-label=\"Scale from 0 to 3%: limit of 0.5% in body lotion and 2% in face cream\"><div class=\"track\"><div class=\"band\" style=\"left:16.6667%;width:50%\"><\/div>\n  <div class=\"pin\" style=\"left:16.6667%\"><strong class=\"num\">0.5%<\/strong><span>Limit in body lotion<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/div><div class=\"pin\" style=\"left:66.6667%\"><strong class=\"num\">2%<\/strong><span>Limit in face cream<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/div><div class=\"ticks\"><span class=\"tick num\" style=\"left:0%\">0%<\/span><span class=\"tick num\" style=\"left:16.6667%\">0.5<\/span><span class=\"tick num\" style=\"left:33.3333%\">1<\/span><span class=\"tick num\" style=\"left:50%\">1.5<\/span><span class=\"tick num\" style=\"left:66.6667%\">2<\/span><span class=\"tick num\" style=\"left:83.3333%\">2.5<\/span><span class=\"tick num\" style=\"left:100%\">3%<\/span><\/div><\/div>\n  <ul class=\"pins-list\" aria-hidden=\"true\"><li><strong class=\"num\">0.5%<\/strong><span>Limit in body lotion<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/li><li><strong class=\"num\">2%<\/strong><span>Limit in face cream<a class=\"ref\" href=\"#src-2\">2<\/a><\/span><\/li><\/ul><\/div><\/div><\/section>\n<section class=\"sec products\" id=\"produits\" aria-labelledby=\"h-p\"><div class=\"wrap\">\n  <div class=\"p-head\"><div><h2 class=\"h2\" id=\"h-p\">Which products use alpha-arbutin?<\/h2>\n  <p class=\"lede\">Our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/\">white label catalog<\/a> includes 2 formulas with alpha-arbutin: the key active in 2 of them, a supporting ingredient in the others. Every category can be customized (formula, fragrance, packaging).<\/p><\/div>\n  <\/div>\n  <div class=\"p-cols\" style=\"--pc:1\"><div class=\"p-col on\" id=\"pc-visage\" role=\"tabpanel\"><h3><span class=\"count num\">2<\/span>Face<\/h3><p>Key active, with kojic acid, of the catalog&#x27;s dark spot serum and cream.<\/p><ul><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-face-creams\/\"><span>Face creams<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-face-serums\/\"><span>Face serums<\/span><span class=\"n\">1<\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><div class=feat><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-face-serums\/kojic-dark-spot-serum\/\"><span>Kojic Dark Spot Serum<small>Key active<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-face-creams\/kojic-acid-dark-spot-cream\/\"><span>Kojic Acid Dark Spot Cream<small>Key active<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/div><\/div><\/div>\n  <div class=\"pairs\"><p>In our formulas, it is most often paired with<\/p><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/licorice-root-extract\/\">Licorice extract <span class=\"num\">2<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/niacinamide\/\">Niacinamide <span class=\"num\">2<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/panthenol\/\">Panthenol <span class=\"num\">2<\/span><\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/vitamin-c\/\">Vitamin C <span class=\"num\">2<\/span><\/a><\/div>\n  <\/div><\/section>\n<section class=\"sec\" id=\"comparatif\" aria-labelledby=\"h-cmp\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-cmp\">Alpha-arbutin, arbutin, kojic acid or niacinamide?<\/h2><p class=\"lede\">Four actives often compared for evening out skin tone. They do not exclude each other: our dark spot serum and cream combine alpha-arbutin, kojic acid and niacinamide.<\/p>\n  <div class=\"seg c-pick\" role=\"group\" aria-label=\"Compare with\" id=\"cpick\"><button type=\"button\" aria-pressed=\"true\" data-c=\"3\">Arbutin<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"4\">Kojic acid<\/button><button type=\"button\" aria-pressed=\"false\" data-c=\"5\">Niacinamide<\/button><\/div>\n  <div class=\"tbl-wrap\"><table class=\"cmp\" id=\"cmp\" data-c=\"3\"><colgroup><col><col class=\"me\"><col><col><col><\/colgroup>\n  <thead><tr><td><\/td><th scope=\"col\">Alpha-arbutin<\/th><th scope=\"col\">Arbutin (beta)<\/th><th scope=\"col\">Kojic acid<\/th><th scope=\"col\">Niacinamide<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Origin<\/th><td>Enzymatic synthesis<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Found in many plants<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Not covered here<\/td><td>Vitamin B3<\/td><\/tr><tr><th scope=\"row\">EU regulation<\/th><td>Restricted: 2% in face cream, 0.5% in body lotion<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Restricted: 7% in face cream<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>Restricted: 1% for face and hands<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>No restriction<\/td><\/tr><tr><th scope=\"row\">Human tyrosinase<\/th><td>Stronger inhibition than beta<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><td>Weaker inhibition than alpha<a class=\"ref\" href=\"#src-5\">5<\/a><\/td><td>Not compared in these studies<\/td><td>Different mode of action: see the niacinamide page<\/td><\/tr><tr><th scope=\"row\">Point of caution<\/th><td>Hydroquinone at the level of unavoidable traces<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Releases hydroquinone at pH 3 or below<a class=\"ref\" href=\"#src-3\">3<\/a><\/td><td>Concentration limit in Annex III<a class=\"ref\" href=\"#src-2\">2<\/a><\/td><td>See the niacinamide page<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/section>\n<section class=\"sec\" id=\"faq\" aria-labelledby=\"h-faq\"><div class=\"wrap faq-grid\">\n  <h2 class=\"h2\" id=\"h-faq\">Frequently asked questions about alpha-arbutin<\/h2><div class=\"faq\"><details open><summary>What is alpha-arbutin?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">It is a hydroquinone glycoside, 4-hydroxyphenyl-alpha-D-glucopyranoside (CAS 84380-01-8). CosIng assigns it the functions antioxidant, skin lightening and skin conditioning<a class=\"ref\" href=\"#src-1\">1<\/a>. It is obtained by enzymatic synthesis, whereas beta-arbutin occurs in many plants<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/div><\/details><details><summary>What are the benefits of alpha-arbutin?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">In the lab, it reduces melanin formation in cells and in a human skin model<a class=\"ref\" href=\"#src-4\">4<\/a> and inhibits human tyrosinase more strongly than beta-arbutin<a class=\"ref\" href=\"#src-5\">5<\/a>. Clinical trials on healthy skin are rare: a 2021 review calls for better quality trials<a class=\"ref\" href=\"#src-8\">8<\/a>.<\/div><\/details><details><summary>What percentage of alpha-arbutin is allowed in cosmetics?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Regulation (EU) 2024\/996 sets 2% maximum in face creams and 0.5% in body lotions, based on the SCCS opinion<a class=\"ref\" href=\"#src-2\">2<\/a><a class=\"ref\" href=\"#src-3\">3<\/a>. The hydroquinone level must stay as low as possible, never above unavoidable traces<a class=\"ref\" href=\"#src-2\">2<\/a>.<\/div><\/details><details><summary>Can you combine alpha-arbutin with vitamin C, kojic acid and niacinamide?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Yes, these are common combinations. Our dark spot cream and serum combine kojic acid and alpha-arbutin, with niacinamide and vitamin C among their supporting actives. Kojic acid has its own 1% limit for face and hand products<a class=\"ref\" href=\"#src-2\">2<\/a>. The stability of the final formula is checked through lab testing.<\/div><\/details><details><summary>Alpha-arbutin: morning or night?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">None of the sources cited sets a time of application.<\/div><\/details><details><summary>Is alpha-arbutin safe, and does it have side effects?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">The SCCS judges it safe at 2% in face cream and 0.5% in body lotion, used alone or together<a class=\"ref\" href=\"#src-3\">3<\/a>. The point of caution is hydroquinone, which must remain at the level of unavoidable traces<a class=\"ref\" href=\"#src-2\">2<\/a>. Skin absorption measured in vitro on human skin is low<a class=\"ref\" href=\"#src-3\">3<\/a>.<\/div><\/details><details><summary>Can you use alpha-arbutin during pregnancy?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">The sources cited do not address pregnancy. As with any targeted skincare product, a healthcare professional's advice remains the rule.<\/div><\/details><details><summary>Can you manufacture an alpha-arbutin serum for my brand?<svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M12 5v14M5 12h14\"\/><\/svg><\/summary><div class=\"a\">Yes. Our <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/iso-22716-certified-cosmetics-manufacturer\/\">ISO 22716 certified<\/a> lab offers 2 alpha-arbutin catalog formulas (dark spot serum and cream) that you can customize, or a <a class=\"txt-link\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-formulation-lab\/\">custom formula<\/a>. Samples are free.<\/div><\/details><\/div><\/div><\/section>\n<section class=\"sec\" id=\"plus\" aria-labelledby=\"h-more\" style=\"padding-top:0\"><div class=\"wrap more-grid\">\n  <div><h2 class=\"h2\" id=\"h-more\">Further reading<\/h2><div class=\"hubs\"><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\">Ingredient glossary<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/personalized-cosmetics-products-catalog\/white-label-face-serums\/\">White label face serums<\/a><a class=\"chip\" href=\"https:\/\/carmelcosmeticslabs.com\/en\/cosmetic-contract-manufacturing-guide\/\">Cosmetic contract manufacturing guide<\/a><\/div><\/div>\n  <ul class=\"more-list\"><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/trending-cosmetic-ingredients-2026\/\"><span><strong>Top 10 trending cosmetic ingredients in 2026<\/strong><small>Mentions alpha-arbutin among the pairings of a trending active<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><li><a href=\"https:\/\/carmelcosmeticslabs.com\/en\/eu-cosmetics-regulation-premium-brands\/\"><span><strong>EU cosmetics regulation: meeting new rules and premium consumer expectations<\/strong><small>The European framework that applies to restricted actives<\/small><\/span><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/a><\/li><\/ul><\/div><\/section>\n<section class=\"sec sources\" id=\"sources\" aria-labelledby=\"h-s\"><div class=\"wrap\">\n  <h2 class=\"h2\" id=\"h-s\">Sources<\/h2><p class=\"lede\">Peer-reviewed studies and official regulatory sources, checked on November 2, 2026.<\/p>\n  <ol class=\"src\"><li id=\"src-1\"><span>European Commission. <em>CosIng, entry ALPHA-ARBUTIN<\/em> (CAS 84380-01-8, EC 617-561-8). <a class=\"txt-link\" href=\"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/54359\" target=\"_blank\" rel=\"noopener\">ec.europa.eu\/growth\/tools-databases\/cosing<\/a><\/span><\/li><li id=\"src-2\"><span>Commission Regulation (EU) 2024\/996 of 3 April 2024 amending Regulation (EC) No 1223\/2009 (vitamin A, alpha-arbutin, arbutin and other substances) : Annex III, entries 375 (kojic acid), 377 (alpha-arbutin) and 378 (arbutin). <a class=\"txt-link\" href=\"https:\/\/eur-lex.europa.eu\/eli\/reg\/2024\/996\/oj\" target=\"_blank\" rel=\"noopener\">eur-lex.europa.eu<\/a><\/span><\/li><li id=\"src-3\"><span>Scientific Committee on Consumer Safety (SCCS). <em>Opinion on the safety of alpha-arbutin and beta-arbutin in cosmetic products<\/em>, SCCS\/1642\/22, final version of 31 January 2023. <a class=\"txt-link\" href=\"https:\/\/health.ec.europa.eu\/publications\/safety-alpha-arbutin-and-beta-arbutin-cosmetic-products_en\" target=\"_blank\" rel=\"noopener\">health.ec.europa.eu<\/a><\/span><\/li><li id=\"src-4\"><span>Sugimoto K, Nishimura T, Nomura K, Sugimoto K, Kuriki T. <em>Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model.<\/em> Biol Pharm Bull. 2004;27(4):510-514. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1248\/bpb.27.510\" target=\"_blank\" rel=\"noopener\">doi:10.1248\/bpb.27.510<\/a><span class=\"tag\">Ezaki Glico (alpha-arbutin manufacturer)<\/span><\/span><\/li><li id=\"src-5\"><span>Sugimoto K, Nishimura T, Nomura K, Sugimoto K, Kuriki T. <em>Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase.<\/em> Chem Pharm Bull (Tokyo). 2003;51(7):798-801. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1248\/cpb.51.798\" target=\"_blank\" rel=\"noopener\">doi:10.1248\/cpb.51.798<\/a><span class=\"tag\">Ezaki Glico (alpha-arbutin manufacturer)<\/span><\/span><\/li><li id=\"src-6\"><span>Funayama M, Arakawa H, Yamamoto R, et al. <em>Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.<\/em> Biosci Biotechnol Biochem. 1995;59(1):143-144. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1271\/bbb.59.143\" target=\"_blank\" rel=\"noopener\">doi:10.1271\/bbb.59.143<\/a><span class=\"tag\">Kurabo Industries<\/span><\/span><\/li><li id=\"src-7\"><span>Khan HMS, Tanveer N, Arshad T, et al. <em>Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: in vitro and in vivo human studies.<\/em> Heliyon. 2023;9(9):e19326. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19326\" target=\"_blank\" rel=\"noopener\">doi:10.1016\/j.heliyon.2023.e19326<\/a><\/span><\/li><li id=\"src-8\"><span>Saeedi M, Khezri K, Seyed Zakaryaei A, Mohammadamini H. <em>A comprehensive review of the therapeutic potential of \u03b1-arbutin.<\/em> Phytother Res. 2021;35(8):4136-4154. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1002\/ptr.7076\" target=\"_blank\" rel=\"noopener\">doi:10.1002\/ptr.7076<\/a><\/span><\/li><li id=\"src-9\"><span>Desmedt B, Courselle P, De Beer JO, et al. <em>Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe.<\/em> J Eur Acad Dermatol Venereol. 2016;30(6):943-950. <a class=\"txt-link\" href=\"https:\/\/doi.org\/10.1111\/jdv.13595\" target=\"_blank\" rel=\"noopener\">doi:10.1111\/jdv.13595<\/a><\/span><\/li><\/ol><\/div><\/section>\n\n<div class=\"fab\" id=\"fab\"><a class=\"btn\" href=\"#consultation\">Create an alpha-arbutin product <span class=\"knob\" aria-hidden=\"true\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.8\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><path d=\"M5 12h14M13 6l6 6-6 6\"\/><\/svg><\/span><\/a><\/div><div class=\"scrim\" id=\"scrim\"><\/div><div class=\"pop\" id=\"pop\" role=\"dialog\" aria-modal=\"false\" aria-labelledby=\"pop-n\" hidden><div class=\"pop-n\" id=\"pop-n\"><\/div><div class=\"pop-body\" id=\"pop-body\"><\/div><div class=\"pop-foot\"><a class=\"txt-link\" id=\"pop-all\" href=\"#sources\">All sources<\/a><button class=\"pop-x\" type=\"button\" id=\"pop-x\">Close<\/button><\/div><\/div>\n<\/div>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@graph\": [{\"@type\": \"WebPage\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/alpha-arbutin\/#webpage\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/alpha-arbutin\/\", \"name\": \"Alpha-Arbutin: Studies, EU Limits and Formulation\", \"inLanguage\": \"en-US\", \"datePublished\": \"2026-11-02\", \"dateModified\": \"2026-11-02\", \"author\": {\"@type\": \"Person\", \"name\": \"Mohamed El Hjouji\", \"jobTitle\": \"Founder and CEO\", \"worksFor\": {\"@type\": \"Organization\", \"name\": \"Carmel Cosmetics Labs\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/\"}}, \"about\": {\"@type\": \"ChemicalSubstance\", \"name\": \"Alpha-arbutin\", \"alternateName\": [\"4-Hydroxyphenyl-alpha-D-glucopyranoside\", \"Alpha-arbutin\"], \"chemicalComposition\": \"C12H16O7\", \"identifier\": \"CAS 84380-01-8\"}, \"mainEntity\": {\"@id\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/alpha-arbutin\/#term\"}, \"isPartOf\": {\"@type\": \"CollectionPage\", \"name\": \"Cosmetic ingredient glossary\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\"}, \"relatedLink\": [\"https:\/\/carmelcosmeticslabs.com\/en\/trending-cosmetic-ingredients-2026\/\", \"https:\/\/carmelcosmeticslabs.com\/en\/eu-cosmetics-regulation-premium-brands\/\"], \"citation\": [{\"@type\": \"WebPage\", \"name\": \"CosIng - ALPHA-ARBUTIN\", \"url\": \"https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/54359\"}, {\"@type\": \"Legislation\", \"name\": \"Commission Regulation (EU) 2024\/996\", \"url\": \"https:\/\/eur-lex.europa.eu\/eli\/reg\/2024\/996\/oj\"}, {\"@type\": \"Report\", \"name\": \"SCCS\/1642\/22 - Opinion on the safety of alpha-arbutin and beta-arbutin in cosmetic products\", \"url\": \"https:\/\/health.ec.europa.eu\/publications\/safety-alpha-arbutin-and-beta-arbutin-cosmetic-products_en\", \"datePublished\": \"2023\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model\", \"sameAs\": \"https:\/\/doi.org\/10.1248\/bpb.27.510\", \"datePublished\": \"2004\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase\", \"sameAs\": \"https:\/\/doi.org\/10.1248\/cpb.51.798\", \"datePublished\": \"2003\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma\", \"sameAs\": \"https:\/\/doi.org\/10.1271\/bbb.59.143\", \"datePublished\": \"1995\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: in vitro and in vivo human studies\", \"sameAs\": \"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19326\", \"datePublished\": \"2023\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"A comprehensive review of the therapeutic potential of \u03b1-arbutin\", \"sameAs\": \"https:\/\/doi.org\/10.1002\/ptr.7076\", \"datePublished\": \"2021\"}, {\"@type\": \"ScholarlyArticle\", \"name\": \"Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe\", \"sameAs\": \"https:\/\/doi.org\/10.1111\/jdv.13595\", \"datePublished\": \"2016\"}]}, {\"@type\": \"DefinedTerm\", \"@id\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/alpha-arbutin\/#term\", \"name\": \"Alpha-arbutin\", \"alternateName\": \"ALPHA-ARBUTIN\", \"description\": \"Synthetic glycoside of hydroquinone, used in cosmetics to slow melanin formation and even out skin tone, within limits set by European regulation.\", \"inDefinedTermSet\": {\"@type\": \"DefinedTermSet\", \"name\": \"Cosmetic ingredient glossary\", \"url\": \"https:\/\/carmelcosmeticslabs.com\/en\/glossary-cosmetic-ingredients\/\"}}, {\"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"What is alpha-arbutin?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"It is a hydroquinone glycoside, 4-hydroxyphenyl-alpha-D-glucopyranoside (CAS 84380-01-8). CosIng assigns it the functions antioxidant, skin lightening and skin conditioning. It is obtained by enzymatic synthesis, whereas beta-arbutin occurs in many plants.\"}}, {\"@type\": \"Question\", \"name\": \"What are the benefits of alpha-arbutin?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"In the lab, it reduces melanin formation in cells and in a human skin model and inhibits human tyrosinase more strongly than beta-arbutin. Clinical trials on healthy skin are rare: a 2021 review calls for better quality trials.\"}}, {\"@type\": \"Question\", \"name\": \"What percentage of alpha-arbutin is allowed in cosmetics?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Regulation (EU) 2024\/996 sets 2% maximum in face creams and 0.5% in body lotions, based on the SCCS opinion. The hydroquinone level must stay as low as possible, never above unavoidable traces.\"}}, {\"@type\": \"Question\", \"name\": \"Can you combine alpha-arbutin with vitamin C, kojic acid and niacinamide?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes, these are common combinations. Our dark spot cream and serum combine kojic acid and alpha-arbutin, with niacinamide and vitamin C among their supporting actives. Kojic acid has its own 1% limit for face and hand products. The stability of the final formula is checked through lab testing.\"}}, {\"@type\": \"Question\", \"name\": \"Alpha-arbutin: morning or night?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"None of the sources cited sets a time of application.\"}}, {\"@type\": \"Question\", \"name\": \"Is alpha-arbutin safe, and does it have side effects?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The SCCS judges it safe at 2% in face cream and 0.5% in body lotion, used alone or together. The point of caution is hydroquinone, which must remain at the level of unavoidable traces. Skin absorption measured in vitro on human skin is low.\"}}, {\"@type\": \"Question\", \"name\": \"Can you use alpha-arbutin during pregnancy?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The sources cited do not address pregnancy. As with any targeted skincare product, a healthcare professional's advice remains the rule.\"}}, {\"@type\": \"Question\", \"name\": \"Can you manufacture an alpha-arbutin serum for my brand?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes. Our ISO 22716 certified lab offers 2 alpha-arbutin catalog formulas (dark spot serum and cream) that you can customize, or a custom formula. Samples are free.\"}}]}]}<\/script>\n<script>(function(){\n  var $=function(s,c){return (c||document).querySelector(s)}, $$=function(s,c){return [].slice.call((c||document).querySelectorAll(s))};\n  var root=document.querySelector('.ig')||document.documentElement;\n\n  \/* Clear the site's sticky header and mobile bottom menu when present (WordPress). *\/\n  function measure(){\n    var h=0,b=0,hd=$('.elementor-location-header'),bm=$('.wp-bottom-menu');\n    if(hd&&\/sticky|fixed\/.test(getComputedStyle(hd).position))h=hd.getBoundingClientRect().height;\n    if(bm){var cs=getComputedStyle(bm);if(cs.display!=='none'&&cs.visibility!=='hidden')b=bm.getBoundingClientRect().height;}\n    root.style.setProperty('--hdr',Math.round(h)+'px'); root.style.setProperty('--bm',Math.round(b)+'px');\n  }\n  measure(); setTimeout(measure,1200); addEventListener('resize',measure,{passive:true});\n\n  \/* Sticky bar: scrollspy, progress, CTA after hero, floating CTA on phones *\/\n  var bar=$('#bar'), prog=$('#prog'), fab=$('#fab'), links=$$('.bar a[href^=\"#\"]').filter(function(a){return !a.classList.contains('btn')});\n  var secs=links.map(function(a){return $(a.getAttribute('href'))});\n  var heroOut=false, formIn=false;\n  function setFab(){fab.classList.toggle('show',heroOut&&!formIn)}\n  new IntersectionObserver(function(e){heroOut=!e[0].isIntersecting;bar.classList.toggle('past',heroOut);$('.bar .btn').tabIndex=heroOut?0:-1;setFab()},{rootMargin:'-80px 0px 0px 0px'}).observe($('#top'));\n  var cons=$('#consultation'); if(cons) new IntersectionObserver(function(e){formIn=e[0].isIntersecting;setFab()},{threshold:0.1}).observe(cons);\n  var nav=$('.bar nav'), current=null;\n  function spy(){\n    var y=innerHeight*0.35, on=null;\n    secs.forEach(function(s,i){if(s&&s.getBoundingClientRect().top<y)on=i});\n    if(on!==current){current=on;links.forEach(function(a,i){a.classList.toggle('on',i===on);a.toggleAttribute('aria-current',i===on)});\n      if(on!==null){var a=links[on];nav.scrollTo({left:a.offsetLeft-24,behavior:matchMedia('(prefers-reduced-motion:reduce)').matches?'auto':'smooth'})}}\n    var max=document.documentElement.scrollHeight-innerHeight; prog.style.transform='scaleX('+(max>0?Math.min(1,scrollY\/max):0)+')';\n  }\n  var raf=0; addEventListener('scroll',function(){if(!raf)raf=requestAnimationFrame(function(){raf=0;spy()})},{passive:true}); spy();\n\n  \/* Source popover (desktop) \/ bottom sheet (phone) *\/\n  var pop=$('#pop'), scrim=$('#scrim'), body=$('#pop-body'), num=$('#pop-n'), openRef=null;\n  function closePop(){ if(!openRef)return; pop.classList.remove('open');scrim.classList.remove('open');openRef.setAttribute('aria-expanded','false');var r=openRef;openRef=null;\n    setTimeout(function(){if(!openRef)pop.hidden=true},320); return r;}\n  function place(ref){\n    if(innerWidth<=640)return;\n    var r=ref.getBoundingClientRect(), w=pop.offsetWidth, h=pop.offsetHeight, m=12;\n    var left=Math.min(Math.max(16,r.left+r.width\/2-w\/2),innerWidth-w-16);\n    var below=r.bottom+m+h<innerHeight-16, top=below?r.bottom+m:r.top-m-h;\n    pop.style.left=left+'px'; pop.style.top=Math.max(16,top)+'px';\n    pop.style.transformOrigin=(r.left+r.width\/2-left)+'px '+(below?'0':'100%');\n  }\n  $$('.ref').forEach(function(a){\n    a.setAttribute('role','button'); a.setAttribute('aria-expanded','false'); a.setAttribute('aria-controls','pop');\n    a.setAttribute('aria-label','Source '+a.textContent);\n    a.addEventListener('click',function(e){\n      e.preventDefault(); e.stopPropagation();\n      if(openRef===a){closePop();return}\n      closePop();\n      var id=a.getAttribute('href').slice(1), li=document.getElementById(id); if(!li)return;\n      num.textContent='Source '+a.textContent; body.innerHTML=li.querySelector('span').innerHTML;\n      $('#pop-all').setAttribute('href','#'+id);\n      pop.hidden=false; place(a); openRef=a; a.setAttribute('aria-expanded','true');\n      requestAnimationFrame(function(){pop.classList.add('open');scrim.classList.add('open')});\n      $('#pop-x').focus({preventScroll:true});\n    });\n  });\n  $('#pop-x').addEventListener('click',function(){var r=closePop();if(r)r.focus({preventScroll:true})});\n  $('#pop-all').addEventListener('click',function(){var id=this.getAttribute('href').slice(1);closePop();var li=document.getElementById(id);if(li){li.classList.add('flash');setTimeout(function(){li.classList.remove('flash')},1600)}});\n  scrim.addEventListener('click',closePop);\n  document.addEventListener('click',function(e){if(openRef&&!pop.contains(e.target))closePop()});\n  document.addEventListener('keydown',function(e){if(e.key==='Escape'&&openRef){var r=closePop();r.focus({preventScroll:true})}});\n  addEventListener('scroll',function(){if(openRef&&innerWidth>640)closePop()},{passive:true});\n\n  \/* Copy identifiers *\/\n  $$('.copy').forEach(function(b){\n    var label=b.lastChild;\n    b.addEventListener('click',function(){\n      var v=b.getAttribute('data-copy'), done=function(){b.classList.add('done');var ig=b.closest('.ig');label.nodeValue=(ig&&ig.getAttribute('data-copied'))||'Copi\u00e9';setTimeout(function(){b.classList.remove('done');label.nodeValue=(ig&&ig.getAttribute('data-copy'))||'Copier'},1500)};\n      try{navigator.clipboard.writeText(v).then(done,function(){sel(b);done()})}catch(_){sel(b);done()}\n    });\n  });\n  function sel(b){var s=b.previousElementSibling,r=document.createRange();r.selectNodeContents(s);var g=getSelection();g.removeAllRanges();g.addRange(r)}\n\n  \/* Research filter *\/\n  $$('#rfilter button').forEach(function(b){b.addEventListener('click',function(){\n    var d=b.getAttribute('data-d'); $$('#rfilter button').forEach(function(x){x.setAttribute('aria-pressed',x===b)});\n    $$('.domain').forEach(function(s){s.hidden=!(d==='all'||s.getAttribute('data-d')===d)});\n  })});\n\n  \/* Product tabs (phones) *\/\n  $$('#ptabs button').forEach(function(b){b.addEventListener('click',function(){\n    $$('#ptabs button').forEach(function(x){x.setAttribute('aria-selected',x===b)});\n    $$('.p-col').forEach(function(c){c.classList.toggle('on',c.id==='pc-'+b.getAttribute('data-p'))});\n  })});\n\n  \/* Comparison picker (phones) *\/\n  $$('#cpick button').forEach(function(b){b.addEventListener('click',function(){\n    $$('#cpick button').forEach(function(x){x.setAttribute('aria-pressed',x===b)}); $('#cmp').setAttribute('data-c',b.getAttribute('data-c'));\n  })});\n\n  \/* Form: inline validation (mockup, no submission) *\/\n  var f=$('#lead'); if(!f) return;\n  f.addEventListener('submit',function(e){\n    e.preventDefault(); var ok=true;\n    [['f-name',function(v){return v.trim().length>1}],['f-email',function(v){return \/^[^\\s@]+@[^\\s@]+\\.[^\\s@]+$\/.test(v)}]].forEach(function(p){\n      var i=$('#'+p[0]), good=p[1](i.value); i.closest('.f').classList.toggle('bad',!good); i.setAttribute('aria-invalid',!good); if(!good&&ok){i.focus();ok=false}\n    });\n    if(ok)$('#f-ok').hidden=false;\n  });\n  $$('#lead input').forEach(function(i){i.addEventListener('input',function(){i.closest('.f').classList.remove('bad');i.removeAttribute('aria-invalid')})});\n})();\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-b1ba0db e-flex e-con-full lpf-sec e-con e-parent\" data-id=\"b1ba0db\" data-element_type=\"container\" data-e-type=\"container\" id=\"consultation\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-e42d6f3 e-flex e-con-full lpf-card e-con e-child\" data-id=\"e42d6f3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba7bfba elementor-widget elementor-widget-html\" data-id=\"ba7bfba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n#consultation{scroll-margin-top:110px}\nbody .e-con.lpf-sec{background:#edf5f2!important;padding:clamp(48px,6vw,88px) 16px!important;margin:0!important}\nbody .e-con.lpf-card{--bg:#fbfdfc;--paper:#fff;--mint:#edf5f2;--ink:#10292a;--muted:#51686a;--line:#d6e4e0;--teal:#2f7266;--deep:#0f3a35;--f-display:\"Proxima Nova\",system-ui,sans-serif;--f-body:\"Lato\",system-ui,sans-serif;\n --display:block;display:block!important;width:100%;max-width:760px!important;margin:0 auto!important;background:#fff;border-radius:28px;padding:clamp(22px,3vw,40px)!important;box-shadow:0 1px 0 rgb(16 58 53\/.04),0 30px 70px -36px rgb(16 58 53\/.45),0 0 0 1px #d6e4e0;color:var(--ink);font:400 16px\/1.55 var(--f-body)}\nbody .e-con.lpf-card *{box-sizing:border-box}\nbody .e-con.lpf-card>.elementor-element,body .lpf-card .elementor-widget-container,body .lpf-card .wpforms-container,body .lpf-card form,body .lpf-card .wpforms-field,body .lpf-card .choices,body .lpf-card .iti{width:100%!important;max-width:100%!important;min-width:0!important;margin:0!important}\nbody .lpf-card .eael-contact-form,body .lpf-card .eael-wpforms{background:transparent!important;padding:0!important;margin:0!important;max-width:none!important;box-shadow:none!important;border:0!important}\nbody .lpf-card .dv-card-head{display:flex;gap:16px;align-items:center;margin-bottom:clamp(16px,1.8vw,22px)}\nbody .lpf-card .dv-avatar{flex:none;width:64px;height:64px;border-radius:20px;object-fit:cover;object-position:30% 30%}\nbody .lpf-card .dv-card-head h2{margin:0;font:680 clamp(21px,2vw,26px)\/1.15 var(--f-display);letter-spacing:-.025em;color:var(--ink)}\nbody .lpf-card .dv-card-head p{margin:4px 0 0;color:var(--muted);font-size:14.5px;line-height:1.45}\nbody .lpf-card .dv-reassure{display:flex;gap:10px;align-items:flex-start;margin:14px 0 0;font-size:13px;line-height:1.45;color:var(--muted)}\nbody .lpf-card .dv-reassure svg{flex:none;width:17px;height:17px;margin-top:1px;color:var(--teal)}\nbody .lpf-card .wpforms-head-container,body .lpf-card .wpforms-title,body .lpf-card .wpforms-description{display:none!important}\nbody .lpf-card .wpforms-field-container{display:grid;gap:14px}\nbody .lpf-card .wpforms-field{padding:0!important;float:none!important;width:auto!important}\nbody .lpf-card .wpforms-field-name .wpforms-field-row{display:grid;grid-template-columns:1fr 1fr;gap:12px;max-width:none!important}\nbody .lpf-card .choices.wpforms-field-row{display:block!important}\nbody .lpf-card .wpforms-field-row-block{width:auto!important;padding:0!important;float:none!important}\nbody .lpf-card .wpforms-field-row::before,body .lpf-card .wpforms-field-row::after{display:none!important}\nbody .lpf-card label.wpforms-field-label,body .lpf-card legend.wpforms-field-label{display:block;font:600 13.5px\/1.3 var(--f-body)!important;color:var(--ink)!important;margin:0 0 7px!important;padding:0!important;text-transform:none!important;letter-spacing:normal!important}\nbody .lpf-card fieldset{border:0!important;padding:0!important;margin:0!important;min-width:0}\nbody .lpf-card .wpforms-label-hide{position:static!important;width:auto!important;height:auto!important;overflow:visible!important;clip:auto!important}\nbody .lpf-card .wpforms-sublabel-hide{position:absolute!important;width:1px!important;height:1px!important;overflow:hidden!important;clip:rect(0 0 0 0)!important}\nbody .lpf-card .wpforms-required-label{color:var(--teal)!important}\nbody .lpf-card input[type=text],body .lpf-card input[type=email],body .lpf-card input[type=tel],body .lpf-card input[type=url],body .lpf-card input[type=number],body .lpf-card select,body .lpf-card textarea{width:100%!important;max-width:none!important;font:400 15.5px\/1.4 var(--f-body)!important;color:var(--ink)!important;background:var(--bg)!important;border:1px solid var(--line)!important;border-radius:14px!important;padding:13px 15px!important;height:auto!important;min-height:50px;box-shadow:none!important;transition:border-color .2s ease,box-shadow .2s ease,background-color .2s ease}\nbody .lpf-card .iti input[type=tel]{padding-left:52px!important}\nbody .lpf-card textarea{min-height:120px;resize:vertical}\nbody .lpf-card input:focus,body .lpf-card select:focus,body .lpf-card textarea:focus{outline:0!important;border-color:var(--teal)!important;background-color:var(--paper)!important;box-shadow:0 0 0 4px rgb(47 114 102\/.14)!important}\nbody .lpf-card ::placeholder{color:#8aa09d;opacity:1}\nbody .lpf-card .wpforms-submit-container{margin-top:6px!important;padding:0!important}\nbody .lpf-card button.wpforms-submit{width:100%!important;display:inline-flex!important;align-items:center;justify-content:center;gap:10px;font:650 16px\/1 var(--f-body)!important;color:#fff!important;background:var(--deep)!important;border:0!important;border-radius:99px!important;padding:19px 26px!important;min-height:58px;cursor:pointer;box-shadow:0 14px 30px -14px rgb(16 58 53\/.7)!important;transition:transform .16s cubic-bezier(.23,1,.32,1),background-color .2s ease}\n@media (hover:hover) and (pointer:fine){body .lpf-card button.wpforms-submit:hover{background:var(--teal)!important}}\nbody .lpf-card button.wpforms-submit:active{transform:scale(.98)}\nbody .lpf-card .wpforms-error,body .lpf-card label.wpforms-error,body .lpf-card em.wpforms-error{display:block;color:#b3261e!important;font-size:12.5px!important;margin-top:5px!important}\nbody .lpf-card input.wpforms-error,body .lpf-card select.wpforms-error,body .lpf-card textarea.wpforms-error{border-color:#d26a5f!important}\nbody .lpf-card .wpforms-confirmation-container-full{background:var(--mint)!important;border:0!important;border-radius:18px!important;color:var(--ink)!important;padding:22px!important}\n@media (max-width:520px){body .lpf-card .wpforms-field-name .wpforms-field-row{grid-template-columns:1fr}}\n<\/style><div class=\"dv-card-head\"><img loading=\"lazy\" class=\"dv-avatar\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/uploads\/2026\/09\/lancer-marque-cosmetique-etape-1-expert-carmel-768x953.webp\" alt=\"Carmel Cosmetics Labs product specialist with a brand founder\" width=\"768\" height=\"953\" loading=\"lazy\" decoding=\"async\" title=\"| Carmel Cosmetics Labs\"><div><h2>Tell us about your project<\/h2><p>A product specialist reviews your request and gets back to you on the channel you prefer.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2bcad0 dv-form eael-wpforms-labels-yes eael-wpforms-form-button-custom elementor-widget elementor-widget-eael-wpforms\" data-id=\"d2bcad0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-wpforms.default\">\n\t\t\t\t\t            <div class=\"eael-contact-form eael-wpforms eael-wpforms-align-default\">\n                                <div class=\"wpforms-container wpforms-container-full wpforms-render-modern\" id=\"wpforms-28270\"><form id=\"wpforms-form-28270\" class=\"wpforms-validate wpforms-form wpforms-ajax-form\" data-formid=\"28270\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/en\/wp-json\/wp\/v2\/pages\/54618\" data-token=\"1a6c3a68ef8f7b7f2f6489a2cc53529c\" data-token-time=\"1794233807\"><div class=\"wpforms-head-container\"><div class=\"wpforms-title\">Lead EN \u2013 Demande de devis<\/div><div class=\"wpforms-description\">Tell us about your project. A product specialist will get back to you shortly.<\/div><\/div><noscript class=\"wpforms-error-noscript\">Please enable JavaScript in your browser to complete this form.<\/noscript><div id=\"wpforms-error-noscript\" style=\"display: none;\">Please enable JavaScript in your browser to complete this form.<\/div><div class=\"wpforms-field-container\"><div id=\"wpforms-28270-field_26-container\" class=\"wpforms-field wpforms-field-html\" data-field-type=\"html\" data-field-id=\"26\"><div id=\"wpforms-28270-field_26\" aria-errormessage=\"wpforms-28270-field_26-error\"><center>CONTACT INFORMATION<\/center><\/div><\/div><div id=\"wpforms-28270-field_8-container\" class=\"wpforms-field wpforms-field-name\" data-field-type=\"name\" data-field-id=\"8\"><fieldset><legend class=\"wpforms-field-label wpforms-label-hide\" aria-hidden=\"false\">Name <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><div class=\"wpforms-field-row wpforms-field-large\"><div class=\"wpforms-field-row-block wpforms-first wpforms-one-half\"><input type=\"text\" id=\"wpforms-28270-field_8\" class=\"wpforms-field-name-first wpforms-field-required\" name=\"wpforms[fields][8][first]\" placeholder=\"First Name\" aria-errormessage=\"wpforms-28270-field_8-error\" required><label for=\"wpforms-28270-field_8\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Pr\u00e9nom<\/label><\/div><div class=\"wpforms-field-row-block wpforms-one-half\"><input type=\"text\" id=\"wpforms-28270-field_8-last\" class=\"wpforms-field-name-last wpforms-field-required\" name=\"wpforms[fields][8][last]\" placeholder=\"Last Name\" aria-errormessage=\"wpforms-28270-field_8-last-error\" required><label for=\"wpforms-28270-field_8-last\" class=\"wpforms-field-sublabel after wpforms-sublabel-hide\">Nom<\/label><\/div><\/div><\/fieldset><\/div><div id=\"wpforms-28270-field_10-container\" class=\"wpforms-field wpforms-field-layout\" data-field-type=\"layout\" data-field-id=\"10\"><div class=\"wpforms-field-layout-columns wpforms-field-layout-preset-50-50\"><div class=\"wpforms-layout-column wpforms-layout-column-50\" ><div id=\"wpforms-28270-field_9-container\" class=\"wpforms-field wpforms-field-email\" data-field-type=\"email\" data-field-id=\"9\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_9\" aria-hidden=\"false\">Email <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"email\" id=\"wpforms-28270-field_9\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][9]\" placeholder=\"Email\" spellcheck=\"false\" aria-errormessage=\"wpforms-28270-field_9-error\" required><\/div><div id=\"wpforms-28270-field_39-container\" class=\"wpforms-field wpforms-field-select wpforms-field-select-style-modern\" data-field-type=\"select\" data-field-id=\"39\"><label class=\"wpforms-field-label\" for=\"wpforms-28270-field_39\">Preferred Contact Method<\/label><select id=\"wpforms-28270-field_39\" class=\"wpforms-field-medium choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-medium\" data-search-enabled=\"\" name=\"wpforms[fields][39]\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'>Please select your preferred method of contact<\/option><option value=\"WhatsApp\"  class=\"choice-1 depth-1\"  >WhatsApp<\/option><option value=\"Email\"  class=\"choice-2 depth-1\"  >Email<\/option><option value=\"Call only\"  class=\"choice-3 depth-1\"  >Call only<\/option><\/select><\/div><\/div><div class=\"wpforms-layout-column wpforms-layout-column-50\" ><div id=\"wpforms-28270-field_11-container\" class=\"wpforms-field wpforms-field-phone\" data-field-type=\"phone\" data-field-id=\"11\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_11\" aria-hidden=\"false\">Phone <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><input type=\"tel\" id=\"wpforms-28270-field_11\" class=\"wpforms-field-medium wpforms-field-required wpforms-smart-phone-field\" data-rule-smart-phone-field=\"true\" name=\"wpforms[fields][11]\" placeholder=\"Phone\" aria-label=\"Phone\" aria-errormessage=\"wpforms-28270-field_11-error\" required><\/div><div id=\"wpforms-28270-field_13-container\" class=\"wpforms-field wpforms-field-text\" data-field-type=\"text\" data-field-id=\"13\"><label class=\"wpforms-field-label wpforms-label-hide\" for=\"wpforms-28270-field_13\" aria-hidden=\"false\">Company or brand name \/ website<\/label><input type=\"text\" id=\"wpforms-28270-field_13\" class=\"wpforms-field-medium\" name=\"wpforms[fields][13]\" placeholder=\"Company or brand name \/ website\" aria-errormessage=\"wpforms-28270-field_13-error\" ><\/div><\/div><\/div><\/div><div id=\"wpforms-28270-field_27-container\" class=\"wpforms-field wpforms-field-html\" data-field-type=\"html\" data-field-id=\"27\"><div id=\"wpforms-28270-field_27\" aria-errormessage=\"wpforms-28270-field_27-error\"><center>PROJECT INFORMATION<\/center><\/div><\/div><div id=\"wpforms-28270-field_35-container\" class=\"wpforms-field wpforms-field-checkbox wpforms-list-2-columns\" data-field-type=\"checkbox\" data-field-id=\"35\"><fieldset><legend class=\"wpforms-field-label\">Which cosmetics category interests you most? <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/legend><ul id=\"wpforms-28270-field_35\" class=\"wpforms-field-required\"><li class=\"choice-1 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_1\" name=\"wpforms[fields][35][]\" value=\"Face care Products\" aria-errormessage=\"wpforms-28270-field_35_1-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_1\">Face care Products<\/label><\/li><li class=\"choice-2 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_2\" name=\"wpforms[fields][35][]\" value=\"Haircare Products\" aria-errormessage=\"wpforms-28270-field_35_2-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_2\">Haircare Products<\/label><\/li><li class=\"choice-3 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_3\" name=\"wpforms[fields][35][]\" value=\"Bodycare Products\" aria-errormessage=\"wpforms-28270-field_35_3-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_3\">Bodycare Products<\/label><\/li><li class=\"choice-4 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_4\" name=\"wpforms[fields][35][]\" value=\"Lipcare Products\" aria-errormessage=\"wpforms-28270-field_35_4-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_4\">Lipcare Products<\/label><\/li><li class=\"choice-5 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_5\" name=\"wpforms[fields][35][]\" value=\"Men&#039;s grooming Products\" aria-errormessage=\"wpforms-28270-field_35_5-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_5\">Men's grooming Products<\/label><\/li><li class=\"choice-6 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_6\" name=\"wpforms[fields][35][]\" value=\"Niche Products\" aria-errormessage=\"wpforms-28270-field_35_6-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_6\">Niche Products<\/label><\/li><li class=\"choice-7 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_7\" name=\"wpforms[fields][35][]\" value=\"Intimate Products\" aria-errormessage=\"wpforms-28270-field_35_7-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_7\">Intimate Products<\/label><\/li><li class=\"choice-8 depth-1\"><input type=\"checkbox\" id=\"wpforms-28270-field_35_8\" name=\"wpforms[fields][35][]\" value=\"Others\" aria-errormessage=\"wpforms-28270-field_35_8-error\" required ><label class=\"wpforms-field-label-inline\" for=\"wpforms-28270-field_35_8\">Others<\/label><\/li><\/ul><\/fieldset><\/div><div id=\"wpforms-28270-field_30-container\" class=\"wpforms-field wpforms-field-select wpforms-field-select-style-modern\" data-field-type=\"select\" data-field-id=\"30\"><label class=\"wpforms-field-label\" for=\"wpforms-28270-field_30\">What would be the quantity of your order per product? <span class=\"wpforms-required-label\" aria-hidden=\"true\">*<\/span><\/label><select id=\"wpforms-28270-field_30\" class=\"wpforms-field-large wpforms-field-required choicesjs-select\" data-size-class=\"wpforms-field-row wpforms-field-large\" data-search-enabled=\"\" name=\"wpforms[fields][30]\" required=\"required\"><option value=\"\" class=\"placeholder\" disabled  selected='selected'><\/option><option value=\"less than 1000 units\"  class=\"choice-1 depth-1\"  >less than 1000 units<\/option><option value=\"1000 - 5000 units\"  class=\"choice-3 depth-1\"  >1000 - 5000 units<\/option><option value=\"5000 - 10000 units\"  class=\"choice-6 depth-1\"  >5000 - 10000 units<\/option><option value=\"10000 - 50000 units\"  class=\"choice-7 depth-1\"  >10000 - 50000 units<\/option><option value=\"more than 50000 units\"  class=\"choice-4 depth-1\"  >more than 50000 units<\/option><option value=\"Not sure yet\"  class=\"choice-8 depth-1\"  >Not sure yet<\/option><\/select><\/div><div id=\"wpforms-28270-field_22-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-type=\"textarea\" data-field-id=\"22\"><label class=\"wpforms-field-label\" for=\"wpforms-28270-field_22\">Please describe your project?<\/label><textarea id=\"wpforms-28270-field_22\" class=\"wpforms-field-medium\" name=\"wpforms[fields][22]\" placeholder=\"Your products and objectives? Detailed cosmetic product specifications? A link to download your reference files or images? Or anything else that might help us better understand your project.\" aria-errormessage=\"wpforms-28270-field_22-error\" ><\/textarea><\/div><div id=\"wpforms-28270-field_24-container\" class=\"wpforms-field wpforms-field-content\" data-field-type=\"content\" data-field-id=\"24\"><div id=\"wpforms-28270-field_24\" class=\"wpforms-field-large wpforms-field-row\" aria-errormessage=\"wpforms-28270-field_24-error\"><p>By submitting this form, you agree to our terms of service and privacy policy.<\/p>\n<div class=\"wpforms-field-content-display-frontend-clear\"><\/div><\/div><\/div><div id=\"wpforms-28270-field_52-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_source\" data-field-type=\"hidden\" data-field-id=\"52\"><input type=\"hidden\" id=\"wpforms-28270-field_52\" name=\"wpforms[fields][52]\"><\/div><div id=\"wpforms-28270-field_53-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_medium\" data-field-type=\"hidden\" data-field-id=\"53\"><input type=\"hidden\" id=\"wpforms-28270-field_53\" name=\"wpforms[fields][53]\"><\/div><div id=\"wpforms-28270-field_54-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_campaign\" data-field-type=\"hidden\" data-field-id=\"54\"><input type=\"hidden\" id=\"wpforms-28270-field_54\" name=\"wpforms[fields][54]\"><\/div><div id=\"wpforms-28270-field_55-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_term\" data-field-type=\"hidden\" data-field-id=\"55\"><input type=\"hidden\" id=\"wpforms-28270-field_55\" name=\"wpforms[fields][55]\"><\/div><div id=\"wpforms-28270-field_56-container\" class=\"wpforms-field wpforms-field-hidden ccl-utm_content\" data-field-type=\"hidden\" data-field-id=\"56\"><input type=\"hidden\" id=\"wpforms-28270-field_56\" name=\"wpforms[fields][56]\"><\/div><div id=\"wpforms-28270-field_57-container\" class=\"wpforms-field wpforms-field-hidden ccl-gclid\" data-field-type=\"hidden\" data-field-id=\"57\"><input type=\"hidden\" id=\"wpforms-28270-field_57\" name=\"wpforms[fields][57]\"><\/div><div id=\"wpforms-28270-field_58-container\" class=\"wpforms-field wpforms-field-hidden ccl-gbraid\" data-field-type=\"hidden\" data-field-id=\"58\"><input type=\"hidden\" id=\"wpforms-28270-field_58\" name=\"wpforms[fields][58]\"><\/div><div id=\"wpforms-28270-field_59-container\" class=\"wpforms-field wpforms-field-hidden ccl-wbraid\" data-field-type=\"hidden\" data-field-id=\"59\"><input type=\"hidden\" id=\"wpforms-28270-field_59\" name=\"wpforms[fields][59]\"><\/div><div id=\"wpforms-28270-field_60-container\" class=\"wpforms-field wpforms-field-hidden ccl-fbclid\" data-field-type=\"hidden\" data-field-id=\"60\"><input type=\"hidden\" id=\"wpforms-28270-field_60\" name=\"wpforms[fields][60]\"><\/div><div id=\"wpforms-28270-field_61-container\" class=\"wpforms-field wpforms-field-hidden ccl-landing\" data-field-type=\"hidden\" data-field-id=\"61\"><input type=\"hidden\" id=\"wpforms-28270-field_61\" name=\"wpforms[fields][61]\"><\/div><div id=\"wpforms-28270-field_62-container\" class=\"wpforms-field wpforms-field-hidden ccl-referrer\" data-field-type=\"hidden\" data-field-id=\"62\"><input type=\"hidden\" id=\"wpforms-28270-field_62\" name=\"wpforms[fields][62]\"><\/div><div id=\"wpforms-28270-field_63-container\" class=\"wpforms-field wpforms-field-hidden ccl-first_touch\" data-field-type=\"hidden\" data-field-id=\"63\"><input type=\"hidden\" id=\"wpforms-28270-field_63\" name=\"wpforms[fields][63]\"><\/div><div id=\"wpforms-28270-field_64-container\" class=\"wpforms-field wpforms-field-hidden ccl-canal\" data-field-type=\"hidden\" data-field-id=\"64\"><input type=\"hidden\" id=\"wpforms-28270-field_64\" name=\"wpforms[fields][64]\"><\/div><div id=\"wpforms-28270-field_65-container\" class=\"wpforms-field wpforms-field-hidden ccl-campagne\" data-field-type=\"hidden\" data-field-id=\"65\"><input type=\"hidden\" id=\"wpforms-28270-field_65\" name=\"wpforms[fields][65]\"><\/div><\/div><!-- .wpforms-field-container --><div class=\"wpforms-submit-container\" ><input type=\"hidden\" name=\"wpforms[id]\" value=\"28270\"><input type=\"hidden\" name=\"wpforms[time_token]\" value=\"1794233807.cad2731ae4f06ddc22316b8faf8fddc8e90cc5e898fcdfb8a4bd72043e9ef590\"><input type=\"hidden\" name=\"page_title\" value=\"\"><input type=\"hidden\" name=\"page_url\" value=\"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/pages\/54618\"><input type=\"hidden\" name=\"url_referer\" value=\"\"><button type=\"submit\" name=\"wpforms[submit]\" id=\"wpforms-submit-28270\" class=\"wpforms-submit\" data-alt-text=\"Sending...\" data-submit-text=\"Get my free consultation\" aria-live=\"assertive\" value=\"wpforms-submit\">Get my free consultation<\/button><img decoding=\"async\" src=\"https:\/\/carmelcosmeticslabs.com\/wp-content\/plugins\/wpforms\/assets\/images\/submit-spin.svg\" class=\"wpforms-submit-spinner\" style=\"display: none;\" width=\"26\" height=\"26\" alt=\"Loading\" title=\"| Carmel Cosmetics Labs\"><\/div><\/form><\/div>  <!-- .wpforms-container -->            <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51906c3 elementor-widget elementor-widget-html\" data-id=\"51906c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<p class=\"dv-reassure\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\"><rect x=\"4\" y=\"11\" width=\"16\" height=\"10\" rx=\"2\"\/><path d=\"M8 11V7a4 4 0 0 1 8 0v4\"\/><\/svg>No obligation. Your information stays confidential and is used only to prepare your quote.<\/p><script>(function(){var s=document.getElementById('consultation');if(!s)return;\nvar re=\/\\\/(demande-de-devis|request-a-quote|kostenvoranschlag-anfordern|%d8%b7%d9%84%d8%a8-%d8%a7%d9%82%d8%aa%d8%a8%d8%a7%d8%b3|\u0637\u0644\u0628-\u0627\u0642\u062a\u0628\u0627\u0633)\\\/?([?#].*)?$\/i;\nvar root=s.closest('[data-elementor-type=\"wp-page\"]')||document;\nroot.querySelectorAll('a[href]').forEach(function(a){var h=a.getAttribute('href')||'',d=h;try{d=decodeURIComponent(h);}catch(e){}if(re.test(h)||re.test(d)){a.setAttribute('href','#consultation');}});\ndocument.addEventListener('click',function(e){var a=e.target.closest&&e.target.closest('a[href=\"#consultation\"]');if(!a)return;e.preventDefault();\nvar sm=!matchMedia('(prefers-reduced-motion: reduce)').matches;s.scrollIntoView({behavior:sm?'smooth':'auto',block:'start'});\nvar f=s.querySelector('form input:not([type=hidden]),form select,form textarea');\nvar off=function(){return Math.abs(s.getBoundingClientRect().top-110)>24},fix=function(){if(off())s.scrollIntoView({behavior:'auto',block:'start'});setTimeout(function(){if(off())s.scrollIntoView({behavior:'auto',block:'start'});if(f)try{f.focus({preventScroll:true})}catch(_){}},350)};\nvar last=-1,still=0,n=0,iv=setInterval(function(){var y=scrollY;still=(y===last)?still+1:0;last=y;if(still>=3||++n>50){clearInterval(iv);fix();}},120);\nif(history.replaceState)history.replaceState(null,'','#consultation');});})();<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Alpha-arbutin in cosmetics: INCI, CAS, lab studies, the limits of Regulation (EU) 2024\/996 (2% face) and 2 white label formulas.<\/p>\n","protected":false},"author":3,"featured_media":54192,"parent":20287,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-54618","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/pages\/54618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/comments?post=54618"}],"version-history":[{"count":0,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/pages\/54618\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/pages\/20287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/media\/54192"}],"wp:attachment":[{"href":"https:\/\/carmelcosmeticslabs.com\/en\/wp-json\/wp\/v2\/media?parent=54618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}